Calcium Binding Proteins Database: Summary

Summary of the Proteins Included in this Database

PROTEIN	DOMAIN	BINDING LOOPS	SOURCE	SUBFAMILY	FUNCTION	STRUCTURE

ALG-2 (ALG2)	I	36-47 73-84	mouse	calpain	unknown	no/no
	II	103-114 139-151
	III	169-180

BM-40/SPARC/ osteonectin (BM40)		239-251 274-285	human	extracellular	unknown	no/yes

calbindin D9k (CALB9)		14-27 54-65	bovine	S100	buffer	yes/yes

calbindin D28k (CALB28)	I	23-34 65-76	human	calbindin D(28k)	unknown	no/no
	II	110-121 154-165
	III	198-209 239-250

calcineurin B (CALCIN)	I	30-41 62-73	human	calcineurin	sensor	no/yes
	II	91-110 140-151

calcium-dependent protein kinase, calmodulin-like domain (CDPK)	I	464-475 500-511	Arabidopsis thaliana	CaM	sensor	no/no
	II	536-547 570-581

calcyclin/S100A6 (CALCYC)		20-33 54-65	bovine	S100	sensor	yes/no

calgranulin C/S100A12 (CALGRAN-C)		18-31 61-72	porcine	S100	unknown	no/no

calmodulin (CALMOD)	I	20-31 56-67	mammalian	CaM	sensor	yes/yes
	II	93-104 129-140

calmodulin-like protein (CALL)	I	20-31 56-67	human	CaM	unknown	no/no
	II	93-104 129-140

mu-calpain, large subunit (CANPI)	I	555-565 598-609	human	calpain	protease	no/no
	II	627-638 664-675
	III	693-704

m-calpain, large subunit (CANPII)	I	542-552 585-596	human	calpain	protease	no/no
	II	615-626 651-662
	III	680-691

n-calpain, large subunit (CANPIII)	I	662-672 705-716	human	calpain	protease	no/no
	II	735-746 771-782
	III	800-811

calpain, small subunit (CANP_sm)	I	109-119 152-163	human	calpain	protease	yes/yes
	II	182-193 218-229
	III	247-258

calretinin (CALRET)	I	29-40 76-87	human	calbindin D(28k)	unknown	no/no
	II	120-131 164-175
	III	208-219 251-262

caltractin (CALTRACT)	I	38-49 74-85	Chlamydomonas reinhardtii	CaM	sensor	no/no
	II	111-122 147-158

grancalcin (GRANCAL)	I	62-72 102-113	human	calpain	unknown	no/no
	II	132-143 168-178
	III	196-207

hippocalcin (HIPP)	I	35-46 72-83	human	neuronal calcium sensor	sensor	no/no
	II	108-119 156-167

MRP-8/S100A8 (MRP-8)		20-33 59-70	human	S100	sensor	no/no

MRP-14/S100A9 (MRP-14)		23-36 67-78	human	S100	sensor	no/no

myosin essential light chain (MYO_ELC)	I	19-32 56-57	scallop	CaM	special case	yes (special case)
	II	94-105 132-143

myosin regulatory light chain (MYO_RLC)	I	28-39 61-72	scallop	CaM	special case	yes (special case)
	II	97-108 133-143

Neuronal Calcium Sensor-1 (NCS1)	I	35-46 72-83	Rattus rattus	neuronal calcium sensor	sensor	no/no
	II	108-119 15-1678

parvalbumin (PARV)		50-61 89-100	pike	parvalbumin	buffer	no/yes

p11/S100A10 (p11)		19-29 57-68	human	S100	unknown	no/no

placental calcium-binding protein/S100A4 (CAPL)		20-33 63-74	human	S100	unknown	no/no

recoverin (RECOV)	I	36-47 73-84	bovine	neuronal calcium sensor	sensor	yes/yes
	II	109-120 159-170


S100A (S100A)		19-32 62-73	human	S100	sensor	no/no

S100B (S100B)		18-31 61-72	human	S100	sensor	yes/no

S100C (S100C)		18-31 66-77	human	S100	unknown	no/no

S100D/S100A5 (S100D)		38-51 78-89	human	S100	unknown	no/no

S100E/S100A3 (S100E)		20-33 63-74	human	S100	unknown	no/no

S100L/S100A2 (S100L)		19-32 63-74	human	S100	unknown	no/no

S100P		19-32 62-73	human	S100	unknown	no/no

sarcoplasmic calcium-binding protein, amphioxous (AMP_SARC)	I	19-30 70-81	Amphioxous	sarcoplasmic CaBP	buffer	no/yes
	90-185	115-126 152-164

sarcoplasmic calcium-binding protein, nereis (NER_SARC)	I	16-27 61-71	sandworm	sarcoplasmic CaBP	buffer	no/yes
	II	104-115 138-149

spectrin (SPECTRIN)		2341-2352 2384-2395	chick	spectrin	unknown	yes/yes

sorcin (SORC)	I	43-53 83-94	human	calpain	unknown	no/no
	II	113-124 149-159
	III	177-188

squidulin (SQUID)	I	20-31 56-67	squid	CaM	unknown	no/no
	II	93-104 130-141

troponin C (TROPC)	I	30-41 66-77	avian	CaM	sensor	yes/yes
	II	106-117 142-153

The letters in parentheses are the identifier used on the main alignment page
Domain = two EF hands
Binding loops = the location of the two binding loops in the domain.
Source = the species whose sequence is used for the residue numbers reported. It is usually the "highest" species for which the sequence is available, unless there is a structure available, in which case the species used for the structure is used here. If a structure is available, the species for which the structure was solved is used. Otherwise, the human sequence is used.
Subfamily = name of the most well-studied member of the subfamily to which the protein belongs.
Function = whether the protein can be classified as a buffer or sensor. Whereas sensors have target proteins and are directly involved in signal transduction, buffers do not have any known targets, and are involved in calcium transport, uptake, and homeostasis.
Structure = whether there is a three-dimensional structure available for the protein or domain. The first entry is for the apo state and the second entry is for the calcium-loaded state.