| Additional names and abbreviations: | SPARC: secreted protein rich in cysteines (SPARC); osteonectin; 43K protein |
|---|---|
| Isoforms: | No information about isoforms is stored in the database |
| Yeast Protein Database Entries: | No links to the YPD are stored in the database |
| Basic Chemical and Physical
Information: |
|
| Number of amino acids: | 10 (Oryctolagus cuniculus) - 304 (Bos taurus) View a list of all sources stored in the database |
| Molecular weight: | 1.097 kD (Oryctolagus cuniculus) - 34.716 kD (Bos taurus) View a list of all sources stored in the database |
| pI: | calculated pI (Homo sapiens) = 4.7 (InfoCard) |
| Number of functional calcium binding sites: | Homo sapiens: 2 (InfoCard) |
| Macroscopic calcium binding constants: | not yet available in the data library |
| Other metal binding constants: | not yet available in the data library |
| Protein stability: | not yet available in the data library |
| Post-translational modifications: | Bos taurus: glycosylation (InfoCard) Homo sapiens: glycosylation (InfoCard) |
| Basic Biological
Information: |
|
| Source organisms: | Bos taurus,
Caenorhabditis elegans,
Gallus gallus,
Homo sapiens,
Mus musculus,
Sus scrofa,
Oryctolagus cuniculus,
Rattus norvegicus,
Xenopus laevis
View an annotated list of all sources stored in the database |
| Tissues: | Homo sapiens: embryonic developing bone (InfoCard) Homo sapiens: embryonic developing teeth (InfoCard) |
| Subcellular localization: | Homo sapiens: extracellular (InfoCard) |
| Regulation: | not yet available in the data library |
| Genomic Information: |
|
| GenBank entries: | View a list of GenBank entries
stored in the database |
| Gene length: | not yet available in the data library |
| Gene structure: | Mus musculus, expressed: GenBank code X12697; 9 introns (InfoCard) Caenorhabditis elegans, expressed: GenBank code L21758; 5 introns (InfoCard) |
| Promoter: | not yet available in the data library |
| Gene copies: | not yet available in the data library |
| Alleles: | no alleles are currently stored in the data library |
| Chromosomal localization: | Homo sapiens, expressed (GenBank code J03040): q31-q33 region of chromosome 5 (InfoCard) Mus musculus, expressed (GenBank code X12697): sub-band B1 region of chromosome 11 (InfoCard) Caenorhabditis elegans, expressed (GenBank code L21758): chromosome 4 (InfoCard) |
BOVINE : MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVAEVPVGANPVQVEVGEFDDGAE
HUMAN : MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVTEVSVGANPVQVEVGEFDDGAE
MOUSE : MRAWIFFLLCLAGRALAAPQQ-TEVAEEIVEEETVVEETGVPVGANPVQVEMGEFEDGAE
RAT : MRAWIFFLLCLAGRALAAPQ--TEAAEEMVAEETVVEETGLPVGANPVQVEMGEFEEGAE
CHICK : MRTWIFFFLCLAGKALAAPQE-ALADETEVIEDLTTEG---PVGANPVQVEVGEFEE-PT
XENOPUS : MRVWVFFVLCLAGKALAAPQQDALPEEEEVIEDVPAEET---VGTNPVQVDVGEFDEAIN
CELEG : MR--YALAACLL--LLAASSF-VDAKKKKIADDELGEL-------------LDNIDA--D
BOVINE : ETEEEVVA-ENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGE-FEKVCSNDNKT
HUMAN : ETEEEVVA-ENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGE-FEKVCSNDNKT
MOUSE : ETVEEVVA-DNPCQNHHCKHGKVCELDESNTPMCVCQDPTSCPAPIGE-FEKVCSNDNKT
RAT : ETPEEVVACNNPCQNHHCKHGKVCD-GESNTPMCVCQDPTSCPAPIGE-FEKVCSNDNKT
CHICK : EDVEEIVA-ENPCQNHHCKHGKVCEVDDNNSPMCVCQDPSSCPAHSGV-FEKVCGTDNKT
XENOPUS : EEEEEEPS-ENPCLNHHCKHGKVCEVDESNTPLCVCQDPSTCPTSVGE-FEKICGTDNKT
CELEG : EEKKSVEPAKNPCEDHQCGWGKECVVGKKGEPTCECI--SKCPELDGDPMDKVCANNNQT
BOVINE : FDSSCHFFATKCTLEGTKK------GHKLHLDYIGPCKYIPPCLDSELTEFPLRMRDWLK
HUMAN : FDSSCHFFATKCTLEGTKK------GHKLHLDYIGPCKYIPPCLDSELTEFPLRMRDWLK
MOUSE : FDSSCHFFATKCTLEGTKK------GHKLHLDYIGPCKYIAPCLDSELTEFPLRMRDWLK
RAT : FDSSCHFFATKCTLEGTKK------GHKLHLDYIGPCKYIAPCLDSELTEFPLRMRDWLK
CHICK : YDSSCHFFATKCTLEGTKK------GHKLHLDYIGPCKFIPACLDTELTEFPLRMRDWLK
XENOPUS : YDSSCHFFATKCTLEGTKK------GHKLHLDYIGPCKYIAPCLDNELSEFPLRIGDWLK
CELEG : FTSLCDLYRERCLCKRKSKECSKAFNAKVHLEYLGECKKLDECTEEHMAQFPERMADWLF
BOVINE : NVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGCDHPVELLARDFEKNYNMYIF
HUMAN : NVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAG-DHPVELLARDFEKNYNMYIF
MOUSE : NVLVTLYERDEGNNLLTEKQKLRVKKIHENEKRLEAG-DHPVELLARDFEKNYNMYIF
RAT : NVLVTLYERDEGNNLLTEKQKLRVKKIHENEKRLEAG-DHPVELLARDFEKNYNMYIF
CHICK : NVLITLYERDEDNNLLTEKQKLKVKNIHENEKRLEAG-DHTVELLARDFEKNYNMYIF
XENOPUS : NVLVSLYERDENNNLLNEKQKLRVKKIHENEKRLESW-RPHSELLVRDFEKNYNMYIF
CELEG : QVMKELKKRRE---------------LH----KLEWE-----ELLSEAENDDEKKHVY
|-helixI-|--loop1----|helixII-| |helixIII|--loop2----|helixIV|
En**nn**nX*Y*ZG#Ix**zn**nn**n* En**nn**nX*Y*ZG#Ix**zn**nn**n*
BOVINE : PVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKE
HUMAN : PVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKQ
MOUSE : PVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALEEWAGCFGIKE
RAT : PVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALEEWAGCFGIKE
CHICK : PVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFEACDLDFDKYIALEEWASCFGIKE
XENOPUS : PVHWQFGQLDQHPIDGYLSHTELSPLRAPLIPMEHCTTRFFDECDIDDDKYIALEEWAKCFGIKE
CELEG : PVIWKFCELDTKPHDKSVSHHELIPITAPVIPMESCIKPFLEGCDANNDGNISIKEWGKCLGIKE
BOVINE : KDIDKDLVI
HUMAN : KDIDKDLVI
MOUSE : QDINKDLVI
RAT : QDINKDLVI
CHICK : QDIDKDLVI
XENOPUS : QDVDKDMIV
CELEG : GEIQERC--
Sequence alignment for entire SPARC subfamily
General information:
Biological roles:
Disease states:
Target molecules:
| Calcium-coordination: |
|
|---|---|
| not yet available in the data library |
|
| Nature of the conformational
changes: |
|
| not yet available in the data library |
|
| Secondary structure: (as reported in the PDB file and its accompanying reference) |
|
| not yet available in the data library |
|
| Additional structural information: | |
|
|
| Available structures: (follow the links from the PDB code to the retrieve the PDB files) |
|
| Calcium Loaded Structures: |
1SRA: Homo sapiens, extracellular calcium-binding domain, pH 7.5 Crystal structure, 2 angstrom resolution, R-value = 19.6, R-free = 24.9 2 Ca ions bound (InfoCard) 1BMO: Homo sapiens, extracellular calcium-binding domain and follistatin-like domain, pH 7.5 Crystal structure, 3.1 angstrom resolution, R-value = 26.2, R-free = 32.2 2 Ca ions bound (InfoCard) |