Home Page for Calretinin

Calretinin

Primary information about calretinin:
Basic chemical and physical information	Basic biological information	Basic genomic information	Metal ion binding constants	Interspecies sequence alignment	Information on function
Summary of structural studies	Information on the conformational change	List of available structures	Information about mutations	References about calretinin	Other web resources about calretinin
Additional information about calretinin:
Information about the evolutionary relationship of calretinin to other proteins

Basic Information

Basic Chemical and Physical Information:
Additional names and abbreviations:	calretinin: 29kD protein; protein 10
Isoforms:	No information about isoforms is stored in the database
Yeast Protein Database Entries:	No links to the YPD are stored in the database

Number of amino acids:	269 (Gallus gallus) - 271 (Rattus norvegicus, Homo sapiens) View a list of all sources stored in the database
Molecular weight:	31.077 kD (Gallus gallus) - 31.522 kD (Homo sapiens) View a list of all sources stored in the database
pI:	calculated pI (Homo sapiens) = 5.1 (InfoCard)
Number of functional calcium binding sites:	not yet available in the data library
Macroscopic calcium binding constants:	not yet available in the data library
Other metal binding constants:	not yet available in the data library
Protein stability:	not yet available in the data library
Post-translational modifications:	not yet available in the data library

Basic Biological Information:
Source organisms:	Gallus gallus, Homo sapiens, Rattus norvegicus View an annotated list of all sources stored in the database
Tissues:	Rattus norvegicus: brain (InfoCard) Rattus norvegicus: ovary (InfoCard) Rattus norvegicus: Leydig cells of the testis (InfoCard)
Subcellular localization:	not yet available in the data library
Regulation:	not yet available in the data library

Genomic Information:
GenBank entries:	View a list of GenBank entries stored in the database
Gene length:	not yet available in the data library
Gene structure:	not yet available in the data library
Promoter:	not yet available in the data library
Gene copies:	not yet available in the data library
Alleles:	no alleles are currently stored in the data library
Chromosomal localization:	Homo sapiens, expressed (GenBank code X56667): q22-q23 region of chromosome 16 (InfoCard)

Interspecies Sequence Alignment


                            |-helixI-|--loop1----|helixII-|
                             En**nn**nX*Y*ZG#Ix**zn**nn**n*

HUMAN   : MAGPQQQPPYLHLAELTASQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMMSKSDNFGE
RAT     : MAGPQQQPPYLHLAELTASQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMMSKSDNFGE
CHICK   : MAG--QRAPHLHLAELSASQFLDVWRHFDADGNGYIEGKELENFFQELESARKGTGVDSKRDSLGD

         |helixIII|--loop 2---|helixIV-|
          En**nn**nX*Y*ZG#Ix**zn**nn**n*

HUMAN   : KMKEFMQKYDKNSDGKIEMAELAQILPTEENFLLCFRQHVGSSA
RAT     : KMKEFMQKYDKNSDGKIEMAELAQILPTEENFLLCFRQHVGSSA
CHICK   : KMKEFMHKYDKNADGKIEMAELAQILPTEENFLLCFRQHVGSSS

          |helixV-|--loop3----|helixVI-|             |helixVII|--loop4----|helixVIII| 
          En**nn**nX*Y*ZG#Ix**zn**nn**n*              En**nn**nX*Y*ZG#Ix**zn**nn**n* 

HUMAN   : EFMEAWRKYDTDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDGKLGLSEMSRLLPVQE
RAT     : EFMEAWRKYDTDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDGKLGLSEMSRLLPVQE
CHICK   : EFMEAWRRYDTDRSGYIEANELKGFLSDLLKKANRPYDEAKLQEYTQTILRMFDMNGDGKLGLSEMSRLLPVQE

                        |helixIX-|--loop5---|-helixX-|
                        En**nn**nX*Y*ZG#Ix**zn**nn**n* 

HUMAN   : NFLLKFQGMKLTSEEFNAIFTFYDKDRSGYIDEHELDALLKDLYEKNKKEINIQQLT
RAT     : NFLLKFQGMKLTSEEFNAIFTFYDKDGSGYIDENELDALLKDLYEKNKKEMNIQQLT
CHICK   : NFLLKFQGMKLSSEEFNAIFAFYDKDGSGFIDEHELDALLKDLYEKNKKEMSIQQLT

          |helixXI-|--loop6---|-helixXII|
          En**nn**nX*Y*ZG#Ix**zn**nn**n*

HUMAN   : NYRKSVMSLAEAGKLYRKDLEIVLCSEPPM
RAT     : TYRKSVMSLAEAGKLYRKDLEIVLCSEPPM
CHICK   : NYRRSIMNLSDGGKLYRKELEVVLCSEPPL

Sequence alignment for the entire calbindin D28k/calretinin subfamily

Functional Information:

General information:

no general functional information is currently stored in the database

Biological roles:

not yet available in the data library

Disease states:

not yet available in the data library

Target molecules:

not yet available in the data library

Structural Information:

Calcium-coordination:
not yet available in the data library

Nature of the conformational changes:
not yet available in the data library

Secondary structure: (as reported in the PDB file and its accompanying reference)
not yet available in the data library

Additional structural information:
no additional structural information is currently stored in the database

Available structures: (follow the links from the PDB code to the retrieve the PDB files)
no structures are currently stored in the database

Information about mutants:

no mutants are currently stored in the database