Home Page for Calcineurin B

Calcineurin B

Primary information about calcineurin B:
Basic chemical and physical information	Basic biological information	Basic genomic information	Metal ion binding constants	Interspecies sequence alignment	Information on function
Summary of structural studies	Information on the conformational change	List of available structures	Information about mutations	References about calcineurin B	Other web resources about calcineurin B

Basic Information

Basic Chemical and Physical Information:
Additional names and abbreviations:	No additional names are stored in the database
Isoforms:	isoform 1 isoform 2
Yeast Protein Database Entries:	CNB1

Number of amino acids:	isoform 1: 169 (Mus musculus, Homo sapiens) - 177 (Naegleria gruberi) isoform 2: 170 (Drosophila melanogaster) - 216 (Rattus norvegicus) View a list of all sources stored in the database
Molecular weight:	isoform 1: 19.142 kD (Mus musculus) - 20.057 kD (Naegleria gruberi) isoform 2: 19.32 kD (Drosophila melanogaster) - 24.979 kD (Rattus norvegicus) View a list of all sources stored in the database
pI:	not yet available in the data library
Number of functional calcium binding sites:	not yet available in the data library
Macroscopic calcium binding constants:	not yet available in the data library
Other metal binding constants:	not yet available in the data library
Protein stability:	not yet available in the data library
Post-translational modifications:	not yet available in the data library

Basic Biological Information:
Source organisms:	isoform 1: Drosophila melanogaster, Homo sapiens, Mus musculus, Naegleria gruberi, Neurospora crassa, Saccharomyces cerevisiae isoform 2: Drosophila melanogaster, Rattus norvegicus View an annotated list of all sources stored in the database
Tissues:	not yet available in the data library
Subcellular localization:	not yet available in the data library
Regulation:	not yet available in the data library

Genomic Information:
GenBank entries:	not yet available in the data library
Gene length:	not yet available in the data library
Gene structure:	not yet available in the data library
Promoter:	not yet available in the data library
Gene copies:	not yet available in the data library
Alleles:	no alleles are currently stored in the data library
Chromosomal localization:	not yet available in the data library

Interspecies Sequence Alignment



                                     |-helixI--|--loop1----|helixII|
                                      En**nn**nX*Y*ZG#Ix**zn**nn**n
  
HUMAN   :         GNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQ
MOUSE   :         GSEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQ
DROSOP  :        MGNETSLPMDMCSNFDADEIRRLGKRFRKLDLDNSGALSIDEFMSLPELQ
CELEG   : MGTNTSSLRPEEVEEMQKGTNFTQKEIKKLYKRFKKLDKDGNGTISKDEFLMIPELA
SCEREV  :      GAAPSKIVDGLLEDTNFDRDEIERLRKRFMKLDRDSSGSIDKNEFMSIPGVS


             |helixIII|--loop2----|helixIV|       |-helixV-|-loop3-----
             En**nn**nX*Y*ZG#Ix**zn**nn**n        En**nn**nX*Y*ZG#Ix**z

HUMAN   : QNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGE
MOUSE   : QNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGE
DROSOP  : QNPLVQRVIDIFDADGNGEVDFKEFIQGVSQFSVRGDKLSKLRFAFRIYDMDNDGYISNGE
CELEG   : VNPLVKRVISIFDENGDGSVNFKEFIAALSVFNAQGDKQRKLEFAFKVYDIDGDGYISNGE
SCEREV  : SNPLAGRIMEVFDADNSGDVDFQEFITGLSIFSGRGSKDEKLRFAFKIYDIDKDGFISNGE


          |helixVI|           |helixVII|---loop4--|helixVIII|
          n**nn**n            En**nn**nX*Y*ZG#Ix**zn**nn**n

HUMAN   : LFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV
MOUSE   : LFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV
DROSOP  : LFQVLKMMVGNNLKDTQLQQIVDKTICFADKDEDGKISFDEFCSVVGNTDIHKKMVVDV
CELEG   : LFTVLKMMVGNNLSDVQLQQIVDKTILEADEDGDGKISFEEFAKTLSHQDLENKMTIRL
SCEREV  : LFIVLKIMVGSNLDDEQLQQIVDRTIVENDSDGDGRLSFEEFKNAIETTEVAKSLTLQYDV

Sequence alignment for the entire calcineurin subfamily

Functional Information:

General information:

no general functional information is currently stored in the database

Biological roles:

not yet available in the data library

Disease states:

not yet available in the data library

Target molecules:

isoform 1: FKBP12-FK506
structural evidence for interaction in Homo sapiens: The immunophilin-immunosuppressant complex is bound to calcineurin in the crystal strucutre (InfoCard)

Structural Information:

Calcium-coordination:
not yet available in the data library

Nature of the conformational changes:
not yet available in the data library

Secondary structure: (as reported in the PDB file and its accompanying reference)
not yet available in the data library

Additional structural information:
View a table of interhelical angles from various structures

Available structures: (follow the links from the PDB code to the retrieve the PDB files)
Target Molecule Bound Structures:	1AUI: isoform 1, Homo sapiens, full length calcineurin heterodimer, Crystal structure, 2.1 angstrom resolution, R-value = 18.7 4 Ca ions bound (InfoCard) 1TCO: isoform 1, Homo sapiens, heterodimer of full length calcineurin B and a fragment of calcineurin A, bound to an immunophilin-immunosupressant complex, Crystal structure, 2.5 angstrom resolution, R-value = 22, R-free = 32.8 4 Ca ions bound , bound to 1 equivalentsof the following portion of FKBP12-FK506: complete molecule (InfoCard)

Information about mutants:

no mutants are currently stored in the database