EF-Hand CaBP Data
Library Sequence Information

Multiple Sequence Alignment of the S100 Subfamily

This alignment was generated with CLUSTALW. Please read about how it was constructed to determine if it suit your needs.



CLUSTAL W (1.74) multiple sequence alignment


S102_BOVIN      ------------------MSSPLEQALAVMVATFHKYSGQEGDKFKLSKGEMKELLHKEL
S102_HUMAN      ------------------MCSSLEQALAVLVTTFHKYSCQEGDKFKLSKGEMKELLHKEL
S104_BOVIN      -------------------AYPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTREL
S104_HUMAN      ------------------MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTREL
S104_MOUSE      ------------------MARPLEEALDVIVSTFHKYSGKEGDKFKLNKTELKELLTREL
S104_RAT        ------------------MARPLEEALDVIVSTFHKYSGNEGDKFKLNKTELKELLTREL
S103_HUMAN      ------------------MARPLEQAVAAIVCTFQEYAGRCGDKYKLCQAELKELLQKEL
S106_MOUSE      ------------------MACPLDQAIGLLVAIFHKYSGKEGDKHTLSKKELKELIQKEL
S106_RAT        ------------------MACPLDQAIGLLVAIFHKYSGKEGDKHTLSKKELKELIQKEL
S106_HUMAN      ------------------MACPLDQAIGLLVAIFHKYSGREGDKHTLSKKELKELIQKEL
S106_RABIT      ------------------MASPLDQAIGLLIGIFHKYSGKEGDKHTLSKKELKELIQKEL
S106_CHICK      ------------------MAAPLDQAIGLLVATFHKYSGKEGDKNSLSKGELKELIQKEL
S105_HUMAN      MPAAWILWAHSHSELHTVMETPLEKALTTMVTTFHKYSGREGSKLTLSRKELKELIKKEL
S113_HUMAN      --------------MAAEPLTELEESIETVVTTFFTFARQEGRKDSLSVNEFKELVTQQL
S113_MOUSE      --------------MAAETLTELEAAIETVVSTFFTFAGREGRKGSLNINEFKELATQQL
S10D_HUMAN      ---------------------STKKSPEELKRIFEKYAAKEGDPDQLSKDELKLLIQAEF
S10D_PIG        ---------------------SAQKSPAELKSIFEKYAAKEGDPNQLSKEELKQLIQAEF
S10D_BOVIN      ---------------------SAKKSPEELKGIFEKYAAKEGDPNQLSKEELKLLLQTEF
S10D_CHICK      -----------------------------------------GDPNQLSKEELKLLIQSEF
S10D_RAT        ---------------------SAKKSPEEMKSIFQKYAAKEGDPNQLSKEELKLLIQSEF
S10A_BOVIN      -------------------GSELETAMETLINVFHAHSGKEGDKYKLSKKELKELLQTEL
S10A_HUMAN      -------------------GSELETAMETLINVFHAHSGKEGDKYKLSKKELKELLQTEL
S10A_RAT        -------------------GSELETAMETLINVFHAHSGKEGDKYKLSKKELKDLLQTEL
S10B_MOUSE      --------------------SELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNEL
S10B_RAT        --------------------SELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNEL
S10B_HUMAN      --------------------SELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNEL
S10B_BOVIN      --------------------SELEKAVVALIDVFHQYSGREGDKHKLKKSELKELINNEL
S10E_HUMAN      -------------------MTELETAMGMIIDVFSRYSGSEGSTQTLTKGELKVLMEKEL
S110_HUMAN      -------------------PSQMEHAMETMMFTFHKFAGDKGY---LTKEDLRVLMEKEF
S110_PIG        -------------------PSQMEHAMETMMFTFHKFAGDKGY---LTKEDLRVLMEKEF
S110_MOUSE      -------------------PSQMEHAMETMMLTFHRFAGDKDH---LTKEDLRVLMEREF
S110_RAT        -------------------PSQMEHAMETMMLTFHRFAGEKNY---LTKEDLRVLMEREF
S110_CHICK      -------------------PSQMEHAMETLMFTFHKYAGDKNY---LSKEDLRALMEKEF
S111_HUMAN      -------------MAKISSPTETERCIESLIAVFQKYAGKDGYNYTLSKTEFLSFMNTEL
S111_RABIT      ----------------MSRPTETERCIESLIAVFQKYAGKDGHSVTLSKTEFLSFMNTEL
S111_MOUSE      ------------------MPTETERCIESLIAVFQKYSGKDGNNTQLSKTEFLSFMNTEL
S111_PIG        ---------------MAKRPTETERCIESLIAIFQKHAGRDGNNTKISKTEFLIFMNTEL
S111_CHICK      --------------MSKVSPTETERCIESLLAVFQRYAGREGDNLKLSKKEFRTFMNTEL
S109_BOVIN      -------------------MSQMESSIETIINIFHQYSVRLGHYDTLIQKEFKQLVQKEL
S109_RABIT      ------------------------------------------------------------
S109_HUMAN      ---------------MTCKMSQLERNIETIINTFHQYSVKLGHPDTLNQGEFKELVRKDL
S109_MOUSE      ---------------ANKAPSQMERSITTIIDTFHQYSRKEGHPDTLSKKEFRQMVEAQL
S109_RAT        --------------MAAKTGSQLERSISTIINVFHQYSRKYGHPDTLNKAEFKEMVNKDL
S112_BOVIN      --------------------TKLEDHLEGIINIFHQYSVRVGHFDTLNKRELKQLITKEL
S112_PIG        --------------------TKLEDHLEGIINIFHQYSVRLGHYDTLIKRELKQLITKEL
S112_HUMAN      --------------------TKLEEHLEGIVNIFHQYSVRKGHFDTLSKGELKQLLTKEL
S108_BOVIN      ------------------MLTDLEXAIDSLIDVYHKYSLXKGNYHAVYXDDLKXLLETE-
S108_HUMAN      ------------------MLTELEKALNSIIDVYHKYSLIKGNFHAVYRDDLKKLLETEC
S108_MOUSE      -------------------PSELEKALSNLIDVYHNYSNIQGNHHALYKNDFKKMVTTEC
S108_RAT        -------------------ATELEKALSNVIEVYHNYSGIKGNHHALYRDDFRKMVTTEC
S107_BOVIN      -----------------MSSSQLEQAITDLINLFHKYSGSDDT---IEKEDLLRLMKDNF
S107_HUMAN      ------------------SNTQAERSIIGMIDMFHKYTRRDDK---IDKPSLLTMMKENF
                                                                            

S102_BOVIN      PSFVGE--KVDEEGLKKLMGDLDENSDQQVDFQEYAVFLALITIMCNDFFQGSPARS---
S102_HUMAN      PSFVGE--KVDEEGLKKLMGNLDENSDQQVDFQEYAVFLALITVMCNDFFQGCPDRP---
S104_BOVIN      PSFLGK--RTDETAFQKLMSNLDCNKDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRK
S104_HUMAN      PSFLGK--RTDEAAFQKLMSNLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRK
S104_MOUSE      PSFLGK--RTDEAAFQKVMSNLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGCPDKEPRK
S104_RAT        PSFLGR--RTDEAAFQKLMNNLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGCPDKEPRK
S103_HUMAN      ATWTPT--EFRECDYNKFMSVLDTNKDCEVDFVEYVRSLACLCLYCHEYFKDCPSEPPCS
S106_MOUSE      TIGS----KLQDAEIARLMDDLDRNKDQEVNFQEYVAFLGALALIYNEALK---------
S106_RAT        TIGA----KLQDAEIARLMDDLDRNKDQEVNFQEYVAFLGALALIYNEALKG--------
S106_HUMAN      TIGS----KLQDAEIARLMEDLDRNKDQEVNFQEYVTFLGALALIYNEALKG--------
S106_RABIT      TIGS----KLQDAEIVKLMDDLDRNKDQEVNFQEYITFLGALAMIYNEALKG--------
S106_CHICK      TIGP----KLKDAEIAGLMEDLDRNKDQEVNFQEYVTFLGALAMIYNEALLQYK------
S105_HUMAN      CLG-----EMKESSIDDLMKSLDKNSDQEIDFKEYSVFLTMLCMAYNDFFLEDNK-----
S113_HUMAN      PHLL-----KDVGSLDEKMKSLDVNQDSELKFNEYWRLIGELAKEIRKKKDLKIRKK---
S113_MOUSE      PHLL-----KDVGSLDEKMKTLDVNQDSELRFSEYWRLIGELAKEVRKEKALGIRKK---
S10D_HUMAN      PSLL-----KGPNTLDDLFQELDKNGDGEVSFEEFQVLVKKISQ----------------
S10D_PIG        PSLL-----KGPRTLDDLFQELDKNGDGEVSFEEFQVLVKKISQ----------------
S10D_BOVIN      PSLL-----KGPSTLDELFEELDKNGDGEVSFEEFQVLVKKISQ----------------
S10D_CHICK      PSLL-----KASSTLDNLFKELDKNGDGEVSYEEFE------------------------
S10D_RAT        PSLL-----KASSTLDNLFKELDKNGDGEVSYEEFEVFFKKLSQ----------------
S10A_BOVIN      SGFLDA--QKDADAVDKVMKELDENGDGEVDFQEYVVLVAALTVACNNFFWENS------
S10A_HUMAN      SGFLDA--QKDVDAVDKVMKELDENGDGEVDFQEYVVLVAALTVACNNFFWENS------
S10A_RAT        SSFLDV--QKDADAVDKIMKELDENGDGEVDFQEFVVLVAALTVACNNFFWENS------
S10B_MOUSE      SHFLEE--IKEQEVVDKVMETLDEDGDGECDFQEFMAFVAMVTTACHEFFEHE-------
S10B_RAT        SHFLEE--IKEQEVVDKVMETLDEDGDGECDFQEFMAFVSMVTTACHEFFEHE-------
S10B_HUMAN      SHFLEE--IKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE-------
S10B_BOVIN      SHFLEE--IKEQEVVDKVMETLDSDGDGECDFQEFMAFVAMITTACHEFFEHE-------
S10E_HUMAN      PGFLQS--GKDKDAVDKLLKDLDANGDAQVDFSEFIVFVAAITSACHKYFEKAGLK----
S110_HUMAN      PGFLEN--QKDPLAVDKIMKDLDQCRDGKVGFQSFFSLIAGLTIACNDYFVVHMKQKGKK
S110_PIG        PGFLEN--QKDPLAVDKIMKDLDQCRDGKVGFQSFFSLIAGLTIACNDYFVVHMKQKGK-
S110_MOUSE      PGFLEN--QKDPLAVDKIMKDLDQCRDGKVGFQSFLSLVAGLTIACNDYFVVNMKQKGKK
S110_RAT        PGFLEN--QKDPLAVDKIMKDLDQCRDGKVGFQSFLSLVAGLIIACNDYFVVHMKQKK--
S110_CHICK      PGFLEN--QRDPMALDKIMKDLDQCRDGKVGFQSFFSLVAGLTIACNDYFVVHMKQKGRK
S111_HUMAN      AAFTKN--QKDPGVLDRMMKKLDTNSDGQLDFSEFLNLIGGLAMACHDSFLKAVPSQKRT
S111_RABIT      AAFTKN--QKDPGVLDRMMKKLDLNSDGQLDFQEFLNLIGGLAVACHESFVKAAPPQKRF
S111_MOUSE      AAFTKN--QKDPGVLDRMMKKLDLNCDGQLDFQEFLNLIGGLAIACHDSFIQT--SQKRI
S111_PIG        AAFTQN--QKDPGVLDRMMKKLDLDSDGQLDFQEFLNLIGGLAIACHDSFIKS--TQK--
S111_CHICK      ASFTKN--QKDPAVVDRMMKRLDINSDGQLDFQEFLNLIGGIAVACHDALLVQPPHP---
S109_BOVIN      PNFLKKQ-KKNEAAINEIMEDLDTNVDKQLSFEEFIMLVARLTVASHEEMHNTAPPGQGH
S109_RABIT      --------------INDIMEDLDTNQDKQLSFEEFVILMARLVHASHEEMHK--------
S109_HUMAN      QNFLKKE-NKNEKVIEHIMEDLDTNADKQLSFEEFIMLMARLTWASHEKMHE-GDEGPGH
S109_MOUSE      ATFMKKE-KRNEALINDIMEDLDTNQDNQLSFEECMMLMAKLIFACHEKLHENNPRGHGH
S109_RAT        PNFLKRE-KRNENLLRDIMEDLDTNQDNQLSFEECMMLMGKLIFACHEKLHENNPRGHDH
S112_BOVIN      PKTLQN--TKDQPTIDKIFQDLDADKDGAVSFEEFVVLVSRVLKTAHIDIHKE-------
S112_PIG        PNTLKN--TKDQGTIDKIFQNLDANQDEQVSFKEFVVLVTDVLITAHDNIHKE-------
S112_HUMAN      ANTIKN--IKDKAVIDEIFQGLDANQDEQVDFQEFISLVAIALKAAHYHTHKE-------
S108_BOVIN      ------------------------------------------------------------
S108_HUMAN      PQYI------RKKGADVWFKELDINTDGAVNFQEFLILVIKMGVAAHKKSHEESHKE---
S108_MOUSE      PQFV------QNINIENLFRELDINSDNAINFEEFLAMVIKVGVASHKDSHKE-------
S108_RAT        PQFV------QNKNTESLFKELDVNSDNAINFEEFLALVIRVGVAAHKDSHKE-------
S107_BOVIN      PNFLGACEKRGRDYLSNIFEKQDKNKDRKIDFSEFLSLLADIATDYHNHSHGAQLCSGGN
S107_HUMAN      PNFLSACDKKGTNYLADVFEKKDKNEDKKIDFSEFLSLLGDIATDYHKQSHGAAPCSGGS
                                                                            

S102_BOVIN      ----------------------
S102_HUMAN      ----------------------
S104_BOVIN      K---------------------
S104_HUMAN      K---------------------
S104_MOUSE      K---------------------
S104_RAT        K---------------------
S103_HUMAN      Q---------------------
S106_MOUSE      ----------------------
S106_RAT        ----------------------
S106_HUMAN      ----------------------
S106_RABIT      ----------------------
S106_CHICK      ----------------------
S105_HUMAN      ----------------------
S113_HUMAN      ----------------------
S113_MOUSE      ----------------------
S10D_HUMAN      ----------------------
S10D_PIG        ----------------------
S10D_BOVIN      ----------------------
S10D_CHICK      ----------------------
S10D_RAT        ----------------------
S10A_BOVIN      ----------------------
S10A_HUMAN      ----------------------
S10A_RAT        ----------------------
S10B_MOUSE      ----------------------
S10B_RAT        ----------------------
S10B_HUMAN      ----------------------
S10B_BOVIN      ----------------------
S10E_HUMAN      ----------------------
S110_HUMAN      ----------------------
S110_PIG        ----------------------
S110_MOUSE      ----------------------
S110_RAT        ----------------------
S110_CHICK      ----------------------
S111_HUMAN      ----------------------
S111_RABIT      ----------------------
S111_MOUSE      ----------------------
S111_PIG        ----------------------
S111_CHICK      ----------------------
S109_BOVIN      RHGPGYGKGGSGSCSGQGSPDQ
S109_RABIT      ----------------------
S109_HUMAN      HHKPGLGEGTP-----------
S109_MOUSE      SHGKGCGK--------------
S109_RAT        RHGKGCGK--------------
S112_BOVIN      ----------------------
S112_PIG        ----------------------
S112_HUMAN      ----------------------
S108_BOVIN      ----------------------
S108_HUMAN      ----------------------
S108_MOUSE      ----------------------
S108_RAT        ----------------------
S107_BOVIN      Q---------------------
S107_HUMAN      Q---------------------


Note: the first three amino acids of calbindin D9k (S10D) are NOT included in the numbering of calbindin D9k in the database

Protein Codes: S102 = S100A2; S103 = S100A3/S100E; S104 = S100A4/placental calcium-binding protein; S105 = S100A5/S100D; S106 = S100A6/calcyclin; S107 = S100A7/psoriasin; S108 = S100A8/MRP-8; S109 = S100A9/MRP-14; S110 = S100A10/p11; S111 = S100C; S112 = S100A12/calgranulin C; S10A = S100A1; S10B = S100B; S10D = S100D; S10E = S100P



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