DNA Transactions at an Atomic Level

The genetic information encoded within DNA is copied, maintained, and decoded by protein machines. Our laboratory uses electron microscopy, X-ray crystallography, and other high-resolution structural and biochemical approaches to investigate the molecular details of how these proteins repair damaged DNA and maintain integrity of the genome during replication.

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Human and bacterial TatD enzymes exhibit apurinic/apyrimidinic (AP) endonuclease activity. Nucleic Acids Res


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Cool story on Noah and Katie's 2022 mBio publication

Professor Eichman elected as AAAS Fellow

Noah receives the 2022 Edward Ferguson Jr. Graduate Award from the Graduate School


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  • High-resolution structure of a native DNA-protein crosslink
     
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  • Time-resolved crystallography to monitor base excision repair by DNA glycosylases
     
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  • HLTF's ancient HIRAN domain binds 3' DNA ends to drive replication fork reversal
     
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  • Bacterial AlkD is the first glycosylase discovered to repair a bulky lesions like the natural product yatakemycin
     
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  • How do DNA repair enzymes search the genome for chemical damage?

  • How are stalled replication forks repaired?

  • SMARCAL1 HARP domain is important for reversal of stalled forks
     
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  • HEAT repeats have emerged as an important nucleic acid binding architecture

  • Base flipping is not a prerequisite for excision repair by DNA glycosylases
     
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  • CH-π interactions important for catalysis of base excision by DNA glycosylase AlkD
     
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  • Crystals used to determine the atomic structures of a protein-DNA complex

  • X-ray diffraction image from a protein crystal

  • Building the atomic structure of a protein-DNA complex into experimental electron density from X-ray diffraction data

  • NMR chemical shift perturbation to monitor protein structural changes induced by DNA binding
     
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