DNA Transactions at an Atomic Level

The genetic information encoded within DNA is copied, maintained, and decoded by protein machines. Our laboratory uses electron microscopy, X-ray crystallography, and other high-resolution structural and biochemical approaches to investigate the molecular details of how these proteins repair damaged DNA and maintain integrity of the genome during replication.

Featured Article

Human and bacterial TatD enzymes exhibit apurinic/apyrimidinic (AP) endonuclease activity. Nucleic Acids Res

In the News

Cool story on Noah and Katie's 2022 mBio publication

Professor Eichman elected as AAAS Fellow

Noah receives the 2022 Edward Ferguson Jr. Graduate Award from the Graduate School

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Training Opportunities Available

  • High-resolution structure of a native DNA-protein crosslink
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  • Time-resolved crystallography to monitor base excision repair by DNA glycosylases
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  • HLTF's ancient HIRAN domain binds 3' DNA ends to drive replication fork reversal
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  • Bacterial AlkD is the first glycosylase discovered to repair a bulky lesions like the natural product yatakemycin
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  • How do DNA repair enzymes search the genome for chemical damage?

  • How are stalled replication forks repaired?

  • SMARCAL1 HARP domain is important for reversal of stalled forks
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  • HEAT repeats have emerged as an important nucleic acid binding architecture

  • Base flipping is not a prerequisite for excision repair by DNA glycosylases
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  • CH-π interactions important for catalysis of base excision by DNA glycosylase AlkD
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  • Crystals used to determine the atomic structures of a protein-DNA complex

  • X-ray diffraction image from a protein crystal

  • Building the atomic structure of a protein-DNA complex into experimental electron density from X-ray diffraction data

  • NMR chemical shift perturbation to monitor protein structural changes induced by DNA binding
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