DNA Transactions at an Atomic Level

The genetic information encoded within DNA is copied, maintained, and decoded by protein machines. Our laboratory uses X-ray crystallography and other high-resolution structural and biochemical approaches to investigate the molecular details of how these proteins repair damaged DNA and carry out DNA synthesis.

Featured Article

The HIRAN domain of helicase-like transcription factor positions the DNA translocase motor to drive efficient DNA fork regression. J Biol Chem


In the News

Professor Eichman honored with endowed chair

Former PhD student Sonja Brooks Fulmer featured on Beyond the Lab

Alyssa and Noah awarded 3-year NSF Graduate Research Fellowships

Deciphering a potent DNA toxin's secrets


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Training Opportunities Available


  • Time-resolved crystallography to monitor base excision repair by DNA glycosylases
     
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  • HLTF's ancient HIRAN domain binds 3' DNA ends to drive replication fork reversal
     
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  • Bacterial AlkD is the first glycosylase discovered to repair a bulky lesions like the natural product yatakemycin
     
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  • How do DNA repair enzymes search the genome for chemical damage?

  • How are stalled replication forks repaired?

  • SMARCAL1 HARP domain is important for reversal of stalled forks
     
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  • HEAT repeats have emerged as an important nucleic acid binding architecture

  • Base flipping is not a prerequisite for excision repair by DNA glycosylases
     
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  • CH-π interactions important for catalysis of base excision by DNA glycosylase AlkD
     
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  • Crystals used to determine the atomic structures of a protein-DNA complex

  • X-ray diffraction image from a protein crystal

  • Building the atomic structure of a protein-DNA complex into experimental electron density from X-ray diffraction data

  • NMR chemical shift perturbation to monitor protein structural changes induced by DNA binding
     
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  • Structural studies of the vertebrate replisome
     
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  • E. coli AidB is a DNA binding protein involved in the bacterial adaptive response to alkylating agents
     
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