Cryo-EM structures of DNA polymerase α–primase during DNA synthesis
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High-resolution structure of a native DNA-protein crosslink
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What is the mechanism of replication fork reversal?
Time-resolved crystallography to monitor base excision repair by DNA glycosylases
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HLTF's HIRAN domain binds 3' DNA ends to drive replication fork reversal
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The DNA glycosylase YcaQ initiates an alternative interstrand DNA crosslink repair pathway in E. coli
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Bacterial AlkD repairs bulky DNA lesions formed by the natural product yatakemycin
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HEAT repeats have emerged as an important nucleic acid binding architecture
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Reistance-based genome mining to identify new genotoxins
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Building the atomic structure of a protein-DNA complex into experimental electron density from X-ray diffraction data
DNA Transactions at an Atomic Level
The genetic information encoded within DNA is copied, maintained, and decoded by protein machines. Our laboratory uses electron microscopy, X-ray crystallography, and other high-resolution structural and biochemical approaches to investigate the molecular details of how these proteins repair damaged DNA and maintain integrity of the genome during replication.
Featured Articles
An interstrand DNA crosslink glycosylase aids Acinetobacter baumannii pathogenesis. Proc Natl Acad Sci USA
In the News
Leah Oswalt awarded NSF Graduate Research Fellowship
Article highlighting Elwood's work on polα–primase
Noah receives the 2022 Edward Ferguson Jr. Graduate Award from the Graduate School
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