EF-Hand CaBP Data
Library Sequence Information

Multiple Sequence Alignment of the Neuronal Calcium Sensors Subfamily

This alignment was generated with CLUSTALW. Please read about how it was constructed to determine if it suit your needs.



CLUSTAL W (1.74) multiple sequence alignment


NCS1_RAT        --GKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFG
NCS1_XENLA      --GKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDATGFQKIYKQFFPFG
NCS1_CAEEL      --GKGNSKLKSSQIRDLAEQTYFTEKEIKQWYKGFVRDCPNGMLTEAGFQKIYKQFFPQG
FREQ_DROME      --GKKSSKLKQDTIDRLTTDTYFTEKEIRQWHKGFLKDCPNGLLTEQGFIKIYKQFFPQG
NCS1_YEAST      --GAKTSKLSKDDLTCLKQSTYFDRREIQQWHKGFLRDCPSGQLAREDFVKIYKQFFPFG
VIS3_HUMAN      --GKQNSKLRPEVLQDLREKTEFTDHELQEWYKGFLKDCPTGHLTVDEFKKIYANFFPYG
VIS3_RAT        --GKQNSKLRPEVLQDLREHTEFTDHELQEWYKGFLKDCPTGHLTVDEFKKIYANFFPYG
VIS3_CHICK      --GKQNSKLRPEVLQDLRENTEFTDHELQEWYKGFLKDCPTGHLTVEEFKKIYANFFPYG
HIPP_HUMAN      --GKQNSKLRPEMLQDLRENTEFSELELQEWYKGFLKDCPTGILNVDEFKKIYANFFPYG
HIPP_RAT        --GKQNSKLRPEMLQDLRENTEFSELELQEWYKGFLKDCPTGILNVDEFKKIYANFFPYG
VIS1_HUMAN      --GKQNSKLAPEVMEDLVKSTEFNEHELKQWYKGFLKDCPSGRLNLEEFQQLYVKFFPYG
VIS1_RAT        --GKQNSKLAPEVMEDLVKSTEFNEHELKQWYKGFLKDCPSGRLNLEEFQQLYVKFFPYG
VIS2_RAT        --GKNNSKLAPEELEDLVQNTEFSEQELKQWYKGFLKDCPSGILNLEEFQQLYIKFFPYG
NCS2_CAEEL      GIKGSKPKLSKEDLEFLKKNTNFTEEQIKEWYKGFVQDCPKGHLTKEQFIKVYKDFFPSG
RECO_BOVIN      -GNSKSGALSKEILEELQLNTKFTEEELSSWYQSFLKECPSGRITRQEFQTIYSKFFPEA
RECO_MOUSE      -GNSKSGALSKEILEELQLNTKFTEEELSAWYQSFLKECPSGRITRQEFESIYSKFFPDS
RECO_HUMAN      -GNSKSGALSKEILEELQLNTKFSEEELCSWYQSFLKDCPTGRITQQQFQSIYAKFFPDT
SMOD_RANCA      -GNTKSGALSKEILEELQLNTKFTQEELCTWYQSFLKECPSGRISKKQFESIYSKFFPDA
VISI_CHICK      -GNSRSSALSREVLQELRASTRYTEEELSRWYEGFQRQCPDGRIRCDEFERIYGNFFPNS
                     .  *  . :  *   * :   ::  *::.* ::** * :    *  :* .***  

NCS1_RAT        DPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRN
NCS1_XENLA      DPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRN
NCS1_CAEEL      DPSDFASFVFKVFDENKDGAIEFHEFIRALSITSRGNLDEKLHWAFKLYDLDQDGFITRN
FREQ_DROME      DPSKFASLVFRVFDENNDGSIEFEEFIRALSVTSKGNLDEKLQWAFRLYDVDNDGYITRE
NCS1_YEAST      SPEDFANHLFTVFDKDNNGFIHFEEFITVLSTTSRGTLEEKLSWAFELYDLNHDGYITFD
VIS3_HUMAN      DASKFAEHVFRTFDTNGDGTIDFREFIIGLSVTRGGKLEQKLKWAFSMYDLDGNGYISRS
VIS3_RAT        DASKFAEHVFRTFDTNSDGTIDFREFIIALSVTSRGKLEQKLKWAFSMYDLDGNGYISRS
VIS3_CHICK      DASKFAEHVFRTFDTNGDGTIDFREFIIALSVTSRGKLEQKLKWAFSMYDLDGNGYISRG
HIPP_HUMAN      DASKFAEHVFRTFDTNSDGTIDFREFIIALSVTSPGRLEQKLMWAFSMYDLDGNGYISRE
HIPP_RAT        DASKFAEHVFRTFDTNSDGTIDFREFIIALSVTSRGRLEQKLMWAFSMYDLDGNGYISRE
VIS1_HUMAN      DASKFGQHAFRTFDKIGDGTIDFREFICALSITSRGXFEQKLNWAFNMYDLDGDGKITXX
VIS1_RAT        DASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLNWAFNMYDLDGDGKITRV
VIS2_RAT        DASKFAQHAFRTFDKNGDGTIDFREFICALSVTSRGSFEQKLNWAFEMYDLDGDGRITRL
NCS2_CAEEL      SAEGFCEHVFRTFDTDNSGFIDFKEFLLAINVTSSGTPEQKLEWAFRMYDIDGNGTIDEK
RECO_BOVIN      DPKAYAQHVFRSFDANSDGTLDFKEYVIALHMTSAGKTNQKLEWAFSLYDVDGNGTISKN
RECO_MOUSE      DPKAYAQHVFRSFDANSDGTLDFKEYVIALHMTTAGKPTQKLEWAFSLYDVDGNGTISKN
RECO_HUMAN      DPKAYAQHVFRSFDSNLDGTLDFKEYVIALHMTTAGKTNQKLEWAFSLYDVDGNGTISKN
SMOD_RANCA      DPKAYAQHVFRSFDANNDGTLDFKEYMIALMMTSSGKANQKLEWAFCLYDVDGNGTINKK
VISI_CHICK      EPQGYARHVFRSFDTNDDGTLDFREYIIALHLTSSGKTHLKLEWAFSLFDVDRNGEVSKS
                ..  :    *  **   .* :.* *::  :  *  *    ** *** ::*:: :* :   

NCS1_RAT        EMLDIVDAIYQMVGNT--VELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADP
NCS1_XENLA      EMLDIVDAIYQMVGNT--VELPEEENTPEKRVDRIFAMMDKNSDGKLTLQEFQEGSKADP
NCS1_CAEEL      EMLSIVDSIYKMVGSS--VQLPEEENTPEKRVDRIFRMMDKNNDAQLTLEEFKEGAKADP
FREQ_DROME      EMYNIVDAIYQMVGQQ--PQ-SEDENTPQKRVDKIFDQMDKNHDGKLTLEEFREGSKADP
NCS1_YEAST      EMLTIVASVYKMMGSM--VTLNEDEATPEMRVKKIFKLMDKNEDGYITLDEFREGSKVDP
VIS3_HUMAN      EMLEIVQAIYKMVSSV--MKMPEDESTPEKRTDKIFRQMDTNNDGKLSLEEFIRGAKSDP
VIS3_RAT        EMLEIVQAIYKMVSSV--MKMPEDESTPEKRTDKIFRQMDTNNDGKLSLEEFIKGAKSDP
VIS3_CHICK      EMLEIVQAIYKMVSSV--MKMPEDESTPEKRTDKIFRQMDTNNDGKLSLEEFIKGAKSDP
HIPP_HUMAN      EMLEIVQAIYKMVSSV--MKMPEDESTPEKRTEKIFRQMDTNNDGKLSLEEFIRGAKSDP
HIPP_RAT        EMLEIVQAIYKMVSSV--MKMPEDESTPEKRTEKIFRQMDTNNDGKLSLEEFIRGAKSDP
VIS1_HUMAN      EMLEIIEAIYKMVGTVIMMKMNEDGLTPEQRVDKIFSKMDXNKDDQITLGEFREAAKSDP
VIS1_RAT        EMLEIIEAIYKMVGTVIMMKMNEDGLTPEQRVDKIFSKMDKNKDDQITLDEFKEAAKSDP
VIS2_RAT        EMLEIIEAIYKMVGTVIMMRMNQDGLTPQQRVDKIFKKMDQDKDDQITLEEFKEAAKSDP
NCS2_CAEEL      EMIKIIEAIYEMLGPE---VTKSADDSPRKRAKMIFEKMDVNNDKELTLKEFVDGCLADK
RECO_BOVIN      EVLEIVTAIFKMISPEDTKHLPEDENTPEKRAEKIWGFFGKKDDDKLTEKEFIEGTLANK
RECO_MOUSE      EVLEIVMAIFKMIKPEDVKLLPDDENTPEKRAEKIWAFFGKKEDDKLTEEEFIEGTLANK
RECO_HUMAN      EVLEIVMAIFKMITPEDVKLLPDDENTPEKRAEKIWKYFGKNDDDKLTEKEFIEGTLANK
SMOD_RANCA      EVLEIITAIFKMINAEDQKHLPEDENTPEKRTNKIWVYFGKKDDDKLTEGEFIQGIVKNK
VISI_CHICK      EVLEIITAIFKMIPEEERLQLPEDENSPQKRADKLWAYFNKGENDKIAEGEFIDGVMKND
                *:  *: ::::*:         .   :*. *.. ::  :.   :  ::  **  .   : 

NCS1_RAT        SIVQALSLYDGLV---------
NCS1_XENLA      SIVQALSLYDGLV---------
NCS1_CAEEL      SIVHALSLYEGLSS--------
FREQ_DROME      RIVQALSLGGG-----------
NCS1_YEAST      SIIGALNLYDGLI---------
VIS3_HUMAN      SIVRLLQCDPSSASQF------
VIS3_RAT        SIVRLLQCDPSSASQF------
VIS3_CHICK      SIVRLLQCDPSSASQF------
HIPP_HUMAN      SIVRLLQCDPSSRSQF------
HIPP_RAT        SIVRLLQCDPSSASQF------
VIS1_HUMAN      SIVLLLQCDIQK----------
VIS1_RAT        SIVLLLQCDIQK----------
VIS2_RAT        SIVLLLQCDMQK----------
NCS2_CAEEL      ELFQILTNEVKK----------
RECO_BOVIN      EILRLIQFEPQKVKEKLKEKKL
RECO_MOUSE      EILRLIQFEPQKVKERIKEKKQ
RECO_HUMAN      EILRLIQFEPQKVKEKMKNA--
SMOD_RANCA      EILRLIQYEPQKVKDKLKEKKH
VISI_CHICK      AIMRLIQYEPKK----------
                 :.  :                


Key: * = perfect match; : = high similarity; . = low similarity

Protein Codes: FREQ = frequinin (not yet in the data library); HIPP = hippocalcin; NCS1 = NCS-1; NCS2 = NCS-2 (not yet in the data library); RECO = recoverin; SMOD = s-modulin (recoverin); VIS1 = visinin-like protein 1/VILIP-1 (not yet in the data library); VIS2 = visinin-like protein 2/VILIP-2 (not yet in the data library); VIS3 = REM-1 protein (not yet in the data library)



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