This alignment was generated with CLUSTALW. Please read about how it was constructed to determine if it suit your needs.
CLUSTAL W (1.74) multiple sequence alignment
CAN3_BOVIN ------------------------------------------------------------
CAN3_PIG ------------------------------------------------------------
CAN3_RAT MPTVISPTVAPRTGAEPRSPGPVPHPAQGKTTEAGGGHPGGIYSAIISRNFPIIGVKEKT
CAN3_MOUSE MPTVISPTVAPRTGAEPRSPGPVPHPAQGKTTEAGGGHPSGIYSAIISRNFPIIGVKEKT
CAN3_HUMAN MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT
CAN3_CHICK ------MPSAINAAVAQQTAAGSVPSTTSTTTEGTGGGTGGIYSAIISRNQPIIKVKEKT
CANS_HUMAN ------------------------------------------------------------
CANS_PIG ------------------------------------------------------------
CANS_BOVIN ------------------------------------------------------------
CANS_RABIT ------------------------------------------------------------
CANS_RAT ------------------------------------------------------------
CAN1_BOVIN ------------------------------------------------------------
CAN1_PIG ------------------------------------------------------------
CAN1_HUMAN ------------------------------------------------------------
CAN1_RABIT ------------------------------------------------------------
CANX_CHICK ------------------------------------------------------------
CAN2_BOVIN ------------------------------------------------------------
CAN2_PIG ------------------------------------------------------------
CAN2_HUMAN ------------------------------------------------------------
CAN2_RABIT ------------------------------------------------------------
CAN2_MOUSE ------------------------------------------------------------
CAN2_RAT ------------------------------------------------------------
CAN2_CHICK ------------------------------------------------------------
CAN_DROME ----------------------------------MDDLRGFLRQAGQEFLNAAGEAAMGA
CAN_SCHMA -----------------------MGRIQIVYSPDENVSGRTNRPGKEVVDPRTGRIIKVK
SORC_HUMAN ------------------------------------------------------------
SORC_CRILO ------------------------------------------------------------
GRAN_HUMAN ------------------------------------------------------------
SORC_SCHJA ------------------------------------------------------------
ALG2_MOUSE ------------------------------------------------------------
CAN3_BOVIN ------------------------------------------------------------
CAN3_PIG ------------------------------------------------------------
CAN3_RAT FEQLHKKCLEKKVLYLDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIGGANRTD
CAN3_MOUSE FEQLRKKCLEKKVLYLDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIGGANRTD
CAN3_HUMAN FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD
CAN3_CHICK YEELHKKCLEENILYEDPDFPPNETSLFYSQKVPIKFEWKRPREICENPRFIIGGANRTD
CANS_HUMAN ------------------------------------------------------------
CANS_PIG ------------------------------------------------------------
CANS_BOVIN ------------------------------------------------------------
CANS_RABIT ------------------------------------------------------------
CANS_RAT ------------------------------------------------------------
CAN1_BOVIN ------------------------------------------------------------
CAN1_PIG ------------------------------------------------------------
CAN1_HUMAN --MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRD
CAN1_RABIT ------------------------------------------------------------
CANX_CHICK ----------MPFGGIAARLQRDRLRAEGVGEHNNAVKYLNQDYEALKQECIESGTLFRD
CAN2_BOVIN ------------------------------------------------------------
CAN2_PIG ------------------------------------------------------------
CAN2_HUMAN ------------MAGIAAKLAKDREAAEGLGSHERAIKYLNQDYEALRNECLEAGTLFQD
CAN2_RABIT ------------------------------------------------------------
CAN2_MOUSE ------------MAGIAIKLAKDREAAEGLGSHERAIKYLNQDYETLRNECLEAGALFQD
CAN2_RAT ------------MAGIAMKLAKDREAAEGLGSHERAIKYLNQDYETLRNECLEAGALFQD
CAN2_CHICK ------------MAGMAAALAKERAAAAGAGRHGQAVPYLGQDFGALRRECLQGGRLFHD
CAN_DROME AKDVVGSVINEIFIKKEADTKRVLPSIKNMRVLGEKSSSLGPYSEVQDYETILNSCLASG
CAN_SCHMA RETPDDYLNVLKPIKGPKRMEFNPYLPKTLTPKGYAKFKLMMNVASKQYETLVKRLKTER
SORC_HUMAN ------------------------------------------------------------
SORC_CRILO ------------------------------------------------------------
GRAN_HUMAN ------------------------------------------------------------
SORC_SCHJA ------------------------------------------------------------
ALG2_MOUSE ------------------------------------------------------------
CAN3_BOVIN ------------------------------------------------------------
CAN3_PIG ------------------------------------------------------------
CAN3_RAT ICQGDLGDCWLLAAIACLTLNERLLFRVIPHDQSFTENYAGIFHFQFWRYGDWVDVVIDD
CAN3_MOUSE ICQGDLGDCWFLAAIACLTLNERLLFRVIPHDQSFTENYAGIFHFQFWRYGDWVDVVIDD
CAN3_HUMAN ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD
CAN3_CHICK ICQGELGDCWFLAAIACLTLNKKLLCRVIPHDQSFIQNYAGIFHFQFWRYGDWVDVIIDD
CANS_HUMAN ------------------------------------------------------------
CANS_PIG ------------------------------------------------------------
CANS_BOVIN ------------------------------------------------------------
CANS_RABIT ------------------------------------------------------------
CANS_RAT ------------------------------------------------------------
CAN1_BOVIN ------------------------------------------------------------
CAN1_PIG ------------------------------------------------------------
CAN1_HUMAN EAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLL
CAN1_RABIT ------------------------------------------------------------
CANX_CHICK PQFPAGPTALGFKELGPYSSKTRGVEWKRPSELVDDPQFIVGGATRTDICQGALGDCWLL
CAN2_BOVIN ------------------------------------------------------------
CAN2_PIG ------------------------------------------------------------
CAN2_HUMAN PSFPAIPSALGFKELGPYSSKTRGMRWKRPTEICADPQFIIGGATRTDICQGALGDCWLL
CAN2_RABIT ------------------------------------------------------------
CAN2_MOUSE PSFPALPSSLGYKELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLL
CAN2_RAT PSFPALPSSLGFKELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLL
CAN2_CHICK PSFPAGPAALGYRELGPNSYKTKGVVWCRPTELCSCPRFIAGGATRTDICQGALGDCWLL
CAN_DROME SLFEDPLFPASNESLQFSRRPDRHIEWLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLL
CAN_SCHMA TLWEDPDFPANDKAIGNLPDFRERIEWKRPHEINPNAKFFAGGASRFDIEQGALGDCWLL
SORC_HUMAN ------------------------------------------------------------
SORC_CRILO ------------------------------------------------------------
GRAN_HUMAN ------------------------------------------------------------
SORC_SCHJA ------------------------------------------------------------
ALG2_MOUSE ------------------------------------------------------------
CAN3_BOVIN ------------------------------------------------------------
CAN3_PIG ------------------------------------------------------------
CAN3_RAT CLPTYNNQLVFTKSNHRNEFWSAL-LEKAYAKLHGSYEALKGGNTTEAMEDFTGGVT--E
CAN3_MOUSE CLPTYNNQLVFTKSNHRNEFWSAL-LEKAYAKLHGSYEALKGGNTTEAMEDFTGGVT--E
CAN3_HUMAN CLPTYNNQLVFTKSNHRNEFWSAL-LEKAYAKLHGSYEALKGGNTTEAMEDFTGGVA--E
CAN3_CHICK CLPTYNNQLVFTKSSQRNEFWSAL-LEKAYAKLHGSYEALKGGNTTEAMEDFTGGVI--E
CANS_HUMAN ------------------------------------------------------------
CANS_PIG ------------------------------------------------------------
CANS_BOVIN ------------------------------------------------------------
CANS_RABIT ------------------------------------------------------------
CANS_RAT ------------------------------------------------------------
CAN1_BOVIN ------------------------------------------------------------
CAN1_PIG ------------------------------------------------------------
CAN1_HUMAN AAIASLTLNDTLLHRVVPHGQSFQ-NGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGK--L
CAN1_RABIT ------------------------------------------------------------
CANX_CHICK AAIGSLTLNEELLHRVVPHGQSFQ-EDYAGIFHFQIWQFGEWVDVVVDDLLPTKDGE--L
CAN2_BOVIN ------------------------------------------------------------
CAN2_PIG ------------------------------------------------------------
CAN2_HUMAN AAIASLTLNEEILARVVPLNQSFQ-ENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGE--L
CAN2_RABIT ------------------------------------------------------------
CAN2_MOUSE AAIASLTLNEEILARVVPPDQSFQ-ENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGE--L
CAN2_RAT AAIASLTLNEEILARVVPLDQSFQ-ENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGE--L
CAN2_CHICK AAIASLTLNEEILARVVPRDQSFQ-DEYAGIFHFQFWQYGEWVDVVVDDRLPTKNGE--L
CAN_DROME AATANLTQESNLFFRVIPAEQSFE-ENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGE--L
CAN_SCHMA AVVASISGYPQLFDQVVPKDQELKGPEYVGVVRFRFWRFGHWVEVLIDDRLPVRQGRNTL
SORC_HUMAN ------------------------------------------------------------
SORC_CRILO ------------------------------------------------------------
GRAN_HUMAN ------------------------------------------------------------
SORC_SCHJA ------------------------------------------------------------
ALG2_MOUSE ------------------------------------------------------------
CAN3_BOVIN ----------------------------------------PSGLNMGELIERMVRNMDNS
CAN3_PIG ----------------------------------------PSGLNMGDLIARMVRNMDES
CAN3_RAT FFEIKDAPSDMYKIMRKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNS
CAN3_MOUSE FFEIKDAPSDMYKIMRKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNS
CAN3_HUMAN FFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNS
CAN3_CHICK FYEIKDAPKDIYKIMKHAIARGSLMASSIDDNLGFHYGAAPRS-DIGELIARMVKNLENA
CANS_HUMAN ------------------------------------------------------------
CANS_PIG ------------------------------------------------------------
CANS_BOVIN ------------------------------------------------------------
CANS_RABIT ------------------------------------------------------------
CANS_RAT ------------------------------------------------------------
CAN1_BOVIN ------------------------------------------------------------
CAN1_PIG ------------------------------------------------------------
CAN1_HUMAN VFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLY
CAN1_RABIT ------------------------------------------------------------
CANX_CHICK LFVHSAECTEFWSALLEKAYAKLNGCYESLSGGSTTEGFEDFTGGVAEMYDLKRAPRNMG
CAN2_BOVIN ------------------------------------------------------------
CAN2_PIG ------------------------------------------------------------
CAN2_HUMAN LFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLF
CAN2_RABIT ------------------------------------------------------------
CAN2_MOUSE LFVHSAEGSEFWSALLEKAYAKINGCYETLSGGATTEGFEDFTGGIAEWYELRKPPPNLF
CAN2_RAT LFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELRKPPPNLF
CAN2_CHICK LFVHSAEGSEFWSALLEKAYAKLNGSYEALSGGTTTEGFEDFTGGIAEWYELQKAPPNLF
CAN_DROME MYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNLF
CAN_SCHMA VFMHSNDPTEFWSALLEKAYAKLNGCYAHLSGGSQSEAMEDLTGGICLSLELNQKERPSD
SORC_HUMAN ------------------------------------------------------------
SORC_CRILO ------------------------------------------------------------
GRAN_HUMAN ------------------------------------------------------------
SORC_SCHJA ------------------------------------------------------------
ALG2_MOUSE ------------------------------------------------------------
CAN3_BOVIN RLRDSDLIPEVSDDRPTR---MIVPVQFETRMACGLVKGHAYSVTGLEEALYKGEKVKLV
CAN3_PIG RLRDSDLIPEVSDDRPTR---TIVPVQFETRMACGLVKGHAYSVTGLEEALFKGEKVKLV
CAN3_RAT LLRDSDLDPRASDDRPSR---TIVPVQYETRMACGLVKGHAYSVTGLEEALFKGEKVKLV
CAN3_MOUSE LLRDSDLDPRGSDDRPSR---TIVPVQYETRMACGLVKGHAYSVTGLEEALFKGEKVKLV
CAN3_HUMAN LLQDSDLDPRGSDERPTR---TIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLV
CAN3_CHICK QMTYSTVDYQGTDERPAW---TIMPMQYETRMSCGLVKGHAYSVTAVEETTYKGEKMRLV
CANS_HUMAN ------------------------------------------------------------
CANS_PIG ------------------------------------------------------------
CANS_BOVIN ------------------------------------------------------------
CANS_RABIT ------------------------------------------------------------
CANS_RAT ------------------------------------------------------------
CAN1_BOVIN ------------------------------------------------------------
CAN1_PIG ------------------------------------------------------------
CAN1_HUMAN QIILKALERGSLLGCSID---ISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLI
CAN1_RABIT ------------------------------------------------------------
CANX_CHICK HIIRKALERGSLLGCSID---ITSAFDMEAVTFKKLVKGHAYSVTAFKDVNYRGQQEQLI
CAN2_BOVIN ------------------------------------------------------------
CAN2_PIG ------------------------------------------------------------
CAN2_HUMAN KIIQKALQKGSLLGCSID---ITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLI
CAN2_RABIT --------------------------------------------------------QKLI
CAN2_MOUSE KIIQKALEKGSLLGCSID---ITSAADSEAVTYQKLVKGHAYSVTGAEEVESSGSLQKLI
CAN2_RAT KIIQKALEKGSLLGCSID---ITSAADSEAVTYQKLVKGHAYSVTGAEEVESSGSLQKLI
CAN2_CHICK KIIQKALQKGSLLGCSID---ITSAAETEAVTSQKLVKGHAYSVTGAEEVNFRGSIQKLI
CAN_DROME TILQKAAERNSMMGCSIEPDPNVTEAETPQGLIRGHAYSITKVCLIDIVTPNRQGKIPMI
CAN_SCHMA LIDQLKIYAQRCCLMGCS----IDSSVMEQKMDNGLIGSHAYSLTGVYPVNYRGRTQWLM
SORC_HUMAN ------------------------------------------------------------
SORC_CRILO ------------------------------------------------------------
GRAN_HUMAN ------------------------------------------------------------
SORC_SCHJA ------------------------------------------------------------
ALG2_MOUSE ------------------------------------------------------------
CAN3_BOVIN RLRNPWG-QVEWNGSWSDSWKDWSYVDKDEKARLQHQVTE--------------------
CAN3_PIG RLRNPWG-QVEWNGSWSDSWKDWSFVDKDEKARLQHQVTEDGEFWMSYDDFIYHFTKLEI
CAN3_RAT RLRNPWG-QVEWNGSWSDGWKDWSFVDKDEKARLQHQVTEDGEFWMSYDDFVYHFTKLEI
CAN3_MOUSE RLRNPWG-QVEWNGSWSDGWKDWSFVDKDEKARLQHQVTEDGEFWMSYDDFVYHFTKLEI
CAN3_HUMAN RLRNPWG-QVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEI
CAN3_CHICK RLRNPWG-QVEWNGPWSDKSEEWNFIDEEEKIRLQHKIAEDGEFWISLEDFMRHFTKLEI
CANS_HUMAN ------------------------------------------------------------
CANS_PIG ------------------------------------------------------------
CANS_BOVIN ------------------------------------------------------------
CANS_RABIT ------------------------------------------------------------
CANS_RAT ------------------------------------------------------------
CAN1_BOVIN ------------------------------------------------------------
CAN1_PIG ------------------------------------------------------------
CAN1_HUMAN RMRNPWG-EVEWTGAWSDSSSEWNNVDPYERDQLRVKM-EDGEFWMSFRDFMREFTRLEI
CAN1_RABIT ------------------------------------------------------------
CANX_CHICK RIRNPWG-QVEWTGAWSDGSSEWDNIDPSDREELQLKM-EDGEFWMSFRDFMREFSRLEI
CAN2_BOVIN ------------------------------------------------------------
CAN2_PIG ------------------------------------------------------------
CAN2_HUMAN RIRNPWG-EVEWTGRWNDNCPSWNTIDPEERERLTRRH-EDGEFWMSFSDFLRHYSRLEI
CAN2_RABIT RIRNPWG-EVEWTGRWNDNCPNWNTVDPEVRERLAERH-EDGEFWMSFSDFLRHYSRLEI
CAN2_MOUSE RIRNPWG-QVEWTGKWNDNCPSWNTVDPEVRANLTERQ-EDGEFWMSFSDFLRHYSRLEI
CAN2_RAT RIRNPWG-QVEWTGKWNDNCPSWNTVDPEVRANLTERQ-EDGEFWMSFSDFLRHYSRLEI
CAN2_CHICK RIRNPWG-EVEWTGKWNDNCPNWSGVDPEVRERLTRRH-EDGEFWMAFNDFLRHYSRLEI
CAN_DROME RMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEI
CAN_SCHMA RLRNPWGDSHEWKGAWCDGSPQWREISEQEKKNINLSFTADGEFWMSYEDFVTCFSRVEV
SORC_HUMAN ------------------------------------------------------------
SORC_CRILO ------------------------------------------------------------
GRAN_HUMAN ------------------------------------------------------------
SORC_SCHJA ------------------------------------------------------------
ALG2_MOUSE ------------------------------------------------------------
CAN3_BOVIN ------------------------------------------------------------
CAN3_PIG CNLTADALESDKL----QTWTVSVNEGRWVRGCSAGTGRNFPDTFWTNPQYRLKLLEEDD
CAN3_RAT CNLTADALESDKL----QTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDD
CAN3_MOUSE CNLTADALESDKL----QTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDD
CAN3_HUMAN CNLTADALQSDKL----QTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDD
CAN3_CHICK CNLTPDTLEADKL----QTWTVSVNEGRWVRGCSAGGCRNYPDTFWTNPQYRLKLLEEDD
CANS_HUMAN ------------------------------------------------------------
CANS_PIG ------------------------------------------------------------
CANS_BOVIN ------------------------------------------------------------
CANS_RABIT ------------------------------------------------------------
CANS_RAT ------------------------------------------------------------
CAN1_BOVIN ------------------------------------------------------------
CAN1_PIG ------------------------------------------------------------
CAN1_HUMAN CNLTPDALKSRTI----RKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDD
CAN1_RABIT ------------------------------------------------------------
CANX_CHICK CNLTPDALTKDEL----SRWHTQVFEGTWRRGSTAGGCRNNPATFWINPQFKIKLLEEDD
CAN2_BOVIN ----------------------------------------YPNTFWMNPQYLIKLEEEDE
CAN2_PIG ----------------------------------------YPNTFWMNPQYLIKLEEEDE
CAN2_HUMAN CNLTPDTLTSDTY----KKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDE
CAN2_RABIT CNLTPDTLTSDTY----KKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYVIKLEEEDE
CAN2_MOUSE CNLTPDTLTCDSY----KKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDE
CAN2_RAT CNLTPDTLTCDSY----KKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDE
CAN2_CHICK CNLTPDTLASDRY----KKWSLLKLDGNWRRGATAGGCRNYPNTFWTNPQYLIKLEEEDE
CAN_DROME CNLSPDSLTEDQQHSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLVDPDE
CAN_SCHMA CHLGLESLEYNQNFHGKRRLDEAIFSGQWQRNVNAGGCINNRTTYWTSPQFRITVEDPDP
SORC_HUMAN ------------------------------------------------------------
SORC_CRILO ------------------------------------------------------------
GRAN_HUMAN ------------------------------------------------------------
SORC_SCHJA ------------------------------------------------------------
ALG2_MOUSE ------------------------------------------------------------
CAN3_BOVIN ------------------------------------------------------------
CAN3_PIG --DPDDSEVICSFLVALMQRNRRKDRKLGANLFTIGFAIYEVPKEMHGNKQ-HLQKDFFL
CAN3_RAT --DPDDSEVICSFLVALMQKNRRKDRKLGANLFTIGFAIYEVPKEMHGNKQ-HLQKDFFL
CAN3_MOUSE --DPEDSEVICSFLVALMQKNRRKDRKLGANLFTIGFAIYEVPKEMHGNKQ-HLQKDFFL
CAN3_HUMAN --DPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQKDFFL
CAN3_CHICK --DPEDEEVICSFLVALMQKNRRKERKLGANLYTIGFAIYEVPKEMHGTKH-HLQKDFFL
CANS_HUMAN ------------------------------------------------------------
CANS_PIG ------------------------------------------------------------
CANS_BOVIN ------------------------------------------------------------
CANS_RABIT ------------------------------------------------------------
CANS_RAT ------------------------------------------------------------
CAN1_BOVIN ------------------------------------------------------------
CAN1_PIG -------------------------------RVRMEDGEFWMSFRDXLREFTRLEICNLT
CAN1_HUMAN PDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFL
CAN1_RABIT ------RESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPRELVGQPALHLKRDFFL
CANX_CHICK --DPGDDEVACSFLVALMQKHRRRERRVGGDMHTIGFAVYEVPEEAQGSQNVHLKKDFFL
CAN2_BOVIN --DQEDGESGCTFLVGLIQKHRQRQRKMGEDMHTIGFGIYEVPEELTGQTNIHLSKKFFL
CAN2_PIG --DQEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELTGQTNIHLSKNFFL
CAN2_HUMAN --DEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFL
CAN2_RABIT --DQEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELRGQTNIHLGKNFFL
CAN2_MOUSE --DEEDGGRGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELTGQTNIHLGKNFFL
CAN2_RAT --DDEDGERGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELTGQTNIHLSKNFFL
CAN2_CHICK --DPDDPEGGCTFLIGLIQKHRRKQRKMGEDMHTIGFAIYEVPPEFSGQTNIHLSKNFFL
CAN_DROME ----EDEEGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRP--QGLNFFR
CAN_SCHMA ----DDDDNKCSVLIGLMQTDIR--KKVGADFQPIGFMVYNAPDDLNTLLS-----RAQL
SORC_HUMAN ------------------------------------------------------------
SORC_CRILO ------------------------------------------------------------
GRAN_HUMAN ------------------------------------------------------------
SORC_SCHJA ------------------------------------------------------------
ALG2_MOUSE ------------------------------------------------------------
CAN3_BOVIN ------------------------------------------------------------
CAN3_PIG YNASKARSRTYINMREVSERFRLPPSEYVIVPSTYEPHQEGEFMLRVFSEKRKLSEEVEN
CAN3_RAT YNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEAEN
CAN3_MOUSE YNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEAEN
CAN3_HUMAN YNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVEN
CAN3_CHICK YNASKARSKTYINMREISERFRLPPSEYVIIPSTYEPHQEGEFILRVFSEKRSLSEEVEN
CANS_HUMAN ---------------------------MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLI
CANS_PIG ---------------------------MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLI
CANS_BOVIN ---------------------------MFLVNSFLKGGGGGGGGGG-LGGGLGNVLGGLI
CANS_RABIT ---------------------------MFLVNSFLKGGGGGGGGGG-LGGGLGNVLGGLI
CANS_RAT ------------------------------------------------------------
CAN1_BOVIN ------------------------------------------------------------
CAN1_PIG PDALKSQRVRNWXTTLYEGTWRRGSTAXGCRNYPATFWVNPQFKIRLEETDDPEDDYGGR
CAN1_HUMAN ANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDD
CAN1_RABIT ANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKRAGTQELDD
CANX_CHICK RNQSRARSETFINLREVSNQIRLPPGEYIVVPSTFEPHKEADFILRVFTEKQSDTAELDE
CAN2_BOVIN TTRARD-VDTFINLRRCSTASSCPP-EYIVVPSTFEPNKDGDFCIRVFSEKKADYQVVDD
CAN2_PIG THRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQVVDD
CAN2_HUMAN TNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDD
CAN2_RABIT TTRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKNGDFCVRVFSEKKADYQAVDD
CAN2_MOUSE TTRARERSDTFINLREVLNRFKLPPGEYVLVPSTFEPHKDGDFCIRVFSEKKADYQAVDD
CAN2_RAT TTRARERSDTFINLREVLNRFKLPPGEYVLVPSTFEPHKNGDFCIRVFSEKKADYQTVDD
CAN2_CHICK TNKAREKSNTFINLREVLNRFKLPAGEYIIVPSTFEPNLNGDFCLRVFSEKNANSTVIDD
CAN_DROME YKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDD
CAN_SCHMA LTRSPIAKSQFINTREVTAQFRVPPGSYVVIPSTFDPNIEVNFILRVFSQTSITEQELDE
SORC_HUMAN ------------------------------MAYPGHPGAGGGY----YPGGYGGAPGGPA
SORC_CRILO ------------------------------MAYPGHPGAGGGY----YPGGYGGAPGGPS
GRAN_HUMAN ------------------------------MAYPGYGGGFGNFSIQ-VPGMQMGQPVPET
SORC_SCHJA ------------------------------------------------------------
ALG2_MOUSE -----------------------------MAAYSYRPGPGGGP---------GP-AAGAA
CAN3_BOVIN ------------------------------------------------------------
CAN3_PIG TISVDRPVRKKKTKPIIFVSDRANSNKELGVDQESEEGQDKTSPDKQEKSPKP-------
CAN3_RAT TISVDRPVKKKKNKPIIFVSDRANSNKELGVDQEAEEGKDKTGPDKQGESPQP-------
CAN3_MOUSE TISVDRPVKKKKNKPIIFVSDRANSNKELGVDQEAEEGKDKAGPEKRGETPQP-------
CAN3_HUMAN TISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQP-------
CAN3_CHICK MIEADRPSKKKKGKPIIFVSDRANSNKELTTDEDAGKDGEKTHVDEKKRS----------
CANS_HUMAN SGAGGGGGGGGGGGGGGGGGGGGTAMRILGGVISAISEAAAQYNPEPPPPRTH-------
CANS_PIG SGAGGGGGGGGGGGGGGGGGG--TAMRILGGVISAISEAAAQYNPEPPPPRTH-------
CANS_BOVIN SGAGGGGGGGGGGGGGGGGTA----MRILGGVISAISEAAAQYNPEPVPPRTH-------
CANS_RABIT SGAGGGGGGGGGGGGGGAGGGG-TAMRILGGVISAISEAAAQYNPEPPPPRTH-------
CANS_RAT ---------------------------------------------------MH-------
CAN1_BOVIN -IQANLP-----------------------------------------------------
CAN1_PIG EIQANLP-----------------------------------------------------
CAN1_HUMAN QIQANLP-----------------------------------------------------
CAN1_RABIT QIQANLP-----------------------------------------------------
CANX_CHICK EISADLA-----------------------------------------------------
CAN2_BOVIN EIEANI------------------------------------------------------
CAN2_PIG EIEADL------------------------------------------------------
CAN2_HUMAN EIEANL------------------------------------------------------
CAN2_RABIT EIEADL------------------------------------------------------
CAN2_MOUSE EIEANI------------------------------------------------------
CAN2_RAT EIEANI------------------------------------------------------
CAN2_CHICK EIEANF------------------------------------------------------
CAN_DROME HVGYGGKADTITPGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELKRILDHSMRDDLP
CAN_SCHMA DNTNQGL---------------------------------------PDDVIEA-------
SORC_HUMAN FPG---------------------------------------------------------
SORC_CRILO FPG---------------------------------------------------------
GRAN_HUMAN GPAILLD----------------G--------------------------YSG-------
SORC_SCHJA ------------------------------------------------------------
ALG2_MOUSE LPD---------------------------------------------------------
CAN3_BOVIN ------------------------------------------------------------
CAN3_PIG -------------EPSNTDQESEEQ-----------------------------------
CAN3_RAT -------------RPGHTDQESEEQQQFRNIFRQI-AGDDMEICADELKNVLNTVVNKHK
CAN3_MOUSE -------------RPGHTDQESEEQQQFRNIFRQI-AGDDMEICADELKNVLNTVVNKHK
CAN3_HUMAN -------------QPGSSDQESEEQQQFRNIFKQI-AGDDMEICADELKKVLNTVVNKHK
CAN3_CHICK --------------SAKAREKSEEETQFRNIFRQI-AGDDMEICREELRNVLNNVVKKHK
CANS_HUMAN -------------YSNIEANESEEVRQFRRLFAQL-AGDDMEVSATELMNILNKVVTRHP
CANS_PIG -------------YSNIEANESEEVRQFRRLFAQL-AGDDMEVSATELMNILNKVVTRHP
CANS_BOVIN -------------YSNIEANESEEVRQFRRLFAQL-AGDDMEVSATELMNILNKVVTRHP
CANS_RABIT -------------YSNIEANESEEVRQFRRLFAQL-AGDDMEVSATELMNILNKVVTRHP
CANS_RAT -------------YSNIEANESEEERQFRKLFVQL-AGDDMEVSATELMNILNKVVTRHP
CAN1_BOVIN --------------DEQVLSEEEIDENFKSLFRQL-AGEDMEISVKELRTILNRIISKHK
CAN1_PIG --------------DEQVLSEGEIDENFKALFRQL-AGEDMEISVRELRTILNRIISKHK
CAN1_HUMAN --------------DEQVLSEEEIDENFKALFRQL-AGEDMEISVKELRTILNRIISKHK
CAN1_RABIT --------------DEQVLSAEEIDENFKALFRQL-AGEDLEISVRELQTILNRITSKHK
CANX_CHICK --------------DEEEITEDDIEDGFKNMFQQL-AGEDMEISVFELKTILNRVIARHK
CAN2_BOVIN --------------DEIDISEDDIDDGFRRLFAQL-AGEDAEISAFELQTILRRVLAKRQ
CAN2_PIG --------------EENDASEDDIDDGFRRLFAQL-AGEDAEISAFELQTILRRVLAKRQ
CAN2_HUMAN --------------EEFDISEDDIDDGVRRLFAQL-AGEDAEISAFELQTILRRVLAKRQ
CAN2_RABIT --------------EEADVSEDDIDDGFRRLFAQL-AGEDAEISAFELQNILRRVLAKRQ
CAN2_MOUSE --------------EEIDANEEDIDDGFRRLFVQL-AGEDAEISAFELQTILRRVLAKRQ
CAN2_RAT --------------EEIEANEEDIGDGFRRLFAQL-AGEDAEISAFELQTILRRVLAKRE
CAN2_CHICK --------------EETEIDEDDIEPSFKKLFGQL-AGSDAEISAFELRSILNKILAKRQ
CAN_DROME KPVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLI-CGPFLKGTPFEEQLGMNDQSNKRL
CAN_SCHMA -------------LKLEDTLLDEDQEIEQKFLAIR-DPKTNAINAVKLGELLNNSTLQDI
SORC_HUMAN ----------------------QTQDPLYGYFAAV-AGQDGQIDADELQRCLTQSGIAGG
SORC_CRILO ----------------------QTQDPLYGYFASV-AGQDGQIDADELQRCLTQSGIAGG
GRAN_HUMAN --------------PAYSDTYSSAGDSVYTYFSAV-AGQDGEVDAEELQRCLTQSGINGT
SORC_SCHJA --------------------MVMDTNSLRHIFSRVDADKSGSISANELQTSL--S--NGL
ALG2_MOUSE ----------------------Q--SFLWNVFQRVDKDRSGVISDNELQQAL--S--NGT
CAN3_BOVIN ------------------------------------------------------------
CAN3_PIG ------------------------------------------------------------
CAN3_RAT DLKTQ----------------GFTLESCRSMIALMDTDGSGRLNLQEFHHLWKKIKAWQK
CAN3_MOUSE DLKTQ----------------GFTLESCRSMIALMDTDGSGRLNLQEFHHLWKKIKAWQK
CAN3_HUMAN DLKTH----------------GFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQK
CAN3_CHICK DLKTE----------------GFELESSRSMIALMDTDGSGKINFDEFRHLWDKIKSWQK
CANS_HUMAN DLKTD----------------GFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQA
CANS_PIG DLKTD----------------GFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQA
CANS_BOVIN DLKTD----------------GFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQA
CANS_RABIT DLKTD----------------GFGLDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQA
CANS_RAT DLKTD----------------GFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQG
CAN1_BOVIN DCGPRL---------------QPGVLPQHGQPHGSRRQWQTGPGGVQHPM--ERIRNYLA
CAN1_PIG DLRTK----------------GFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLA
CAN1_HUMAN DLRTK----------------GFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLS
CAN1_RABIT DLRTK----------------GFSMESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLA
CANX_CHICK DLKTD----------------GFSLDSCRNMVNLMDKDGSARLGLVEFQILWNKIRSWLT
CAN2_BOVIN DIKSD----------------GFSIETCKIMVDMLD------------------------
CAN2_PIG DIKSD----------------GFSIETCRIMVDMLDSDGSAKLGLKEFYILWTKIQKYQK
CAN2_HUMAN DIKSD----------------GFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQK
CAN2_RABIT DIKTD----------------GLSIETCKIMVDMLDSDGTGKLGLKEFYVLWTKIQKYQK
CAN2_MOUSE DIKSD----------------GFSIETCKIMVDMLDEDGSGKLGLKEFYILWTKIQKYQK
CAN2_RAT DIKSD----------------GFSIETCKIMVDMLDEDGSGKLGLKEFYILWTKIQKYQK
CAN2_CHICK DIKSD----------------GFSIETCKIMVDLLDNDGSGKLGLKEFHTLWTKIQKYQK
CAN_DROME IGDNPADGGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKA
CAN_SCHMA PNFQG-----------------FNKELCRSMVASVDNNLTGHVELNEFMDLWIQAKGWKH
SORC_HUMAN YKPFN-------------------LETCRLMVSMLDRDMSGTMGFNEFKELWAVLNGWRQ
SORC_CRILO YKPFN-------------------LETCRLMVSMLDRDMSGTMGFNEFKELWAVLNGWRQ
GRAN_HUMAN YSPFS-------------------LETCRIMIAMLDRDHTGKMGFNAFKELWAALNAWKE
SORC_SCHJA GTPLN-------------------IRTVQLMVAMFDRDMNGTINFNEFLGLFKYVQDWQT
ALG2_MOUSE WTPFN-------------------PVTVRSIISMFDRENKAGVNFSEFTGVWKYITDWQN
CAN3_BOVIN ------------------------------------------------------------
CAN3_PIG ------------------------------------------------------------
CAN3_RAT IFKHYDTDHSGTINSYEMRNAVNDAGFHLNSQLYDIITMRYADKHM-NIDFDSFICCFVR
CAN3_MOUSE IFKHYDTDHSGTINSYEMRNAVNDAGFHLNSQLYDIITMRYADKHM-NIDFDSFICCFVR
CAN3_HUMAN IFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHM-NIDFDSFICCFVR
CAN3_CHICK IFKHYDADHSGTINSYEMRNAVKDAGFRLNNQLYDIITMRYADKNM-NIDFDSFICCFVR
CANS_HUMAN IYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESG-NMDFDNFISCLVR
CANS_PIG IYKQFDVDRSGTIGSSELPGAFEAAGFHLNEHLYSMIIRRYSDEGG-NMDFDNFISCLVR
CANS_BOVIN VYKQFDVDRSGTIGSSELPGAFEAAGFRLNEHLYNMIIRRYSDEGG-NMDFDNFISCLVR
CANS_RABIT IYKQFDVDRSGTICSRELPGAFEAAGFHLNEHLYNMIIRRYSDEAG-NMDFDNFISCLVR
CANS_RAT IYKRFDTDRSGTIGSNELPGAFEAAGFHLNQHIYSMIIRRYSDETG-NMDFDNFISCLVR
CAN1_BOVIN I-----------------------------------------------------------
CAN1_PIG I-----------------------------------------------------------
CAN1_HUMAN IFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDL-AVDFDNFVCCLVR
CAN1_RABIT IFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDL-AVDFDNFVCCLVR
CANX_CHICK IFRQYDLDKSGTMSSYEMRMALESAGFKLNNKLHQVVVARYADAET-GVDFDNFVCCLVK
CAN2_BOVIN ------------------------------------------------------------
CAN2_PIG IYREIDVDRSGTMNSYEMRKALEEAGFKLPCQLHQVIVARFADDQL-IIDFDNFVRCLVR
CAN2_HUMAN IYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQL-IIDFDNFVRCLVR
CAN2_RABIT IYREIDVDRSGTMNSYEMRKALEEAGFKLPCQLHEVIVARFADDQL-IIDFDNFVRCLVR
CAN2_MOUSE IYREIDVDRSGTMNSYEMRKALEEAGFKLPCQLHQVIVARFADDEL-IIDFDNFVRCLVR
CAN2_RAT IYREIDVDRSGTMNSYEMRKALEEAGFKLPCQLHQVIVARFADDEL-IIDFDNFVRCLVR
CAN2_CHICK IYREIDVDRSGTMNSYEMRRALEAAGFKLSCQLHQIIVARFADEDL-IIDFDNCVRCLIR
CAN_DROME IFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDG-KIAFDDFIMCAVK
CAN_SCHMA IFIKHDVDQSGYFSAYEFREALNDAGYHVSNRLINAIINRYQDPGTDKISFEDFMLCMVR
SORC_HUMAN HFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTN--GKITFDDYIACCVK
SORC_CRILO HFISFDSDRSGTVDPQELQKALTTMGFRLNPQTVNSIAKRYSTS--GKITFDDYIACCVK
GRAN_HUMAN NFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSKN--GRIFFDDYVACCVK
SORC_SCHJA CFRRYDRDNSGSIDLNEFSNALISFGYHLSPQFVNLMMRRFDRN-RGSIAFDDFIYACVC
ALG2_MOUSE VFRTYDRDNSGMIDKNELKQALSGFGYRLSDQFHDILIRKFDRQGRGQIAFDDFIQGCIV
CAN3_BOVIN -----------------------------------
CAN3_PIG -----------------------------------
CAN3_RAT LEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA--
CAN3_MOUSE LEGMFRAFNAFDKDGDGIIKLNVLEWLQLTMYA--
CAN3_HUMAN LEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA--
CAN3_CHICK LDAMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA--
CANS_HUMAN LDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS--
CANS_PIG LDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS--
CANS_BOVIN LDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS--
CANS_RABIT LDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS--
CANS_RAT LDAMFRAFRSLDKNGTGQIQVNIQEWLQLTMYS--
CAN1_BOVIN -----------------------------------
CAN1_PIG -----------------------------------
CAN1_HUMAN LETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA--
CAN1_RABIT LETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA--
CANX_CHICK LETMFRFFHSMDRDGTGTAVMNLAEWLLLTMCG--
CAN2_BOVIN -----------------------------------
CAN2_PIG LETLFRISKQLDSENTGTIELDLISWLCFSVL---
CAN2_HUMAN LETLFKIFKQLDPENTGTIELDLISWLCFSVL---
CAN2_RABIT LETLFKIFKQLDPDNTGMIQLDLISWLCFSVL---
CAN2_MOUSE LETLFKIFKQLDPENTGTIQLNLASWLSFSVL---
CAN2_RAT LEILFKIFKQLDPENTGTIQLDLISWLSFSVL---
CAN2_CHICK LETLYKMFRKLDTEKTGTIELNLINWLFFTVI---
CAN_DROME IKTYIDIFKERDTEKNETATFTLEEWIERTIYS--
CAN_SCHMA LKTAFETIEAHPKNIEGTSLFSAEDYLRFSVYI--
SORC_HUMAN LRALTDSFRRRDTAQQGVVNFPYDDFIQCVMSV--
SORC_CRILO LRALTDSFRRRDSAQQGMVNFSYDDFIQCVMTV--
GRAN_HUMAN LRALTDFFRKRDHLQQGSANFIYDDFLQGTMAI--
SORC_SCHJA LQTLTREFSRYDCRGIGHTVFSFEQFLTSAFAVII
ALG2_MOUSE LQRLTDIFRRYDTDQDGWIQVSYEQYLSMVFSIV-
Protein Codes:
ALG2 = ALG-2; CAN = calpain large subunit, lower animal isoform; CAN1 = calpain large subunit, isoform I; CAN2 = calpain large subunit, isoform II; CAN3 = calpain large subunit, isoform III; GRAN = grancalcin; SORC = sorcin |
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