EF-Hand CaBP Data
Library Sequence Information

Multiple Sequence Alignment of the Calpain Subfamily

This alignment was generated with CLUSTALW. Please read about how it was constructed to determine if it suit your needs.



CLUSTAL W (1.74) multiple sequence alignment


CAN3_BOVIN      ------------------------------------------------------------
CAN3_PIG        ------------------------------------------------------------
CAN3_RAT        MPTVISPTVAPRTGAEPRSPGPVPHPAQGKTTEAGGGHPGGIYSAIISRNFPIIGVKEKT
CAN3_MOUSE      MPTVISPTVAPRTGAEPRSPGPVPHPAQGKTTEAGGGHPSGIYSAIISRNFPIIGVKEKT
CAN3_HUMAN      MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKT
CAN3_CHICK      ------MPSAINAAVAQQTAAGSVPSTTSTTTEGTGGGTGGIYSAIISRNQPIIKVKEKT
CANS_HUMAN      ------------------------------------------------------------
CANS_PIG        ------------------------------------------------------------
CANS_BOVIN      ------------------------------------------------------------
CANS_RABIT      ------------------------------------------------------------
CANS_RAT        ------------------------------------------------------------
CAN1_BOVIN      ------------------------------------------------------------
CAN1_PIG        ------------------------------------------------------------
CAN1_HUMAN      ------------------------------------------------------------
CAN1_RABIT      ------------------------------------------------------------
CANX_CHICK      ------------------------------------------------------------
CAN2_BOVIN      ------------------------------------------------------------
CAN2_PIG        ------------------------------------------------------------
CAN2_HUMAN      ------------------------------------------------------------
CAN2_RABIT      ------------------------------------------------------------
CAN2_MOUSE      ------------------------------------------------------------
CAN2_RAT        ------------------------------------------------------------
CAN2_CHICK      ------------------------------------------------------------
CAN_DROME       ----------------------------------MDDLRGFLRQAGQEFLNAAGEAAMGA
CAN_SCHMA       -----------------------MGRIQIVYSPDENVSGRTNRPGKEVVDPRTGRIIKVK
SORC_HUMAN      ------------------------------------------------------------
SORC_CRILO      ------------------------------------------------------------
GRAN_HUMAN      ------------------------------------------------------------
SORC_SCHJA      ------------------------------------------------------------
ALG2_MOUSE      ------------------------------------------------------------
                                                                            

CAN3_BOVIN      ------------------------------------------------------------
CAN3_PIG        ------------------------------------------------------------
CAN3_RAT        FEQLHKKCLEKKVLYLDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIGGANRTD
CAN3_MOUSE      FEQLRKKCLEKKVLYLDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIGGANRTD
CAN3_HUMAN      FEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTD
CAN3_CHICK      YEELHKKCLEENILYEDPDFPPNETSLFYSQKVPIKFEWKRPREICENPRFIIGGANRTD
CANS_HUMAN      ------------------------------------------------------------
CANS_PIG        ------------------------------------------------------------
CANS_BOVIN      ------------------------------------------------------------
CANS_RABIT      ------------------------------------------------------------
CANS_RAT        ------------------------------------------------------------
CAN1_BOVIN      ------------------------------------------------------------
CAN1_PIG        ------------------------------------------------------------
CAN1_HUMAN      --MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRD
CAN1_RABIT      ------------------------------------------------------------
CANX_CHICK      ----------MPFGGIAARLQRDRLRAEGVGEHNNAVKYLNQDYEALKQECIESGTLFRD
CAN2_BOVIN      ------------------------------------------------------------
CAN2_PIG        ------------------------------------------------------------
CAN2_HUMAN      ------------MAGIAAKLAKDREAAEGLGSHERAIKYLNQDYEALRNECLEAGTLFQD
CAN2_RABIT      ------------------------------------------------------------
CAN2_MOUSE      ------------MAGIAIKLAKDREAAEGLGSHERAIKYLNQDYETLRNECLEAGALFQD
CAN2_RAT        ------------MAGIAMKLAKDREAAEGLGSHERAIKYLNQDYETLRNECLEAGALFQD
CAN2_CHICK      ------------MAGMAAALAKERAAAAGAGRHGQAVPYLGQDFGALRRECLQGGRLFHD
CAN_DROME       AKDVVGSVINEIFIKKEADTKRVLPSIKNMRVLGEKSSSLGPYSEVQDYETILNSCLASG
CAN_SCHMA       RETPDDYLNVLKPIKGPKRMEFNPYLPKTLTPKGYAKFKLMMNVASKQYETLVKRLKTER
SORC_HUMAN      ------------------------------------------------------------
SORC_CRILO      ------------------------------------------------------------
GRAN_HUMAN      ------------------------------------------------------------
SORC_SCHJA      ------------------------------------------------------------
ALG2_MOUSE      ------------------------------------------------------------
                                                                            

CAN3_BOVIN      ------------------------------------------------------------
CAN3_PIG        ------------------------------------------------------------
CAN3_RAT        ICQGDLGDCWLLAAIACLTLNERLLFRVIPHDQSFTENYAGIFHFQFWRYGDWVDVVIDD
CAN3_MOUSE      ICQGDLGDCWFLAAIACLTLNERLLFRVIPHDQSFTENYAGIFHFQFWRYGDWVDVVIDD
CAN3_HUMAN      ICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDD
CAN3_CHICK      ICQGELGDCWFLAAIACLTLNKKLLCRVIPHDQSFIQNYAGIFHFQFWRYGDWVDVIIDD
CANS_HUMAN      ------------------------------------------------------------
CANS_PIG        ------------------------------------------------------------
CANS_BOVIN      ------------------------------------------------------------
CANS_RABIT      ------------------------------------------------------------
CANS_RAT        ------------------------------------------------------------
CAN1_BOVIN      ------------------------------------------------------------
CAN1_PIG        ------------------------------------------------------------
CAN1_HUMAN      EAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLL
CAN1_RABIT      ------------------------------------------------------------
CANX_CHICK      PQFPAGPTALGFKELGPYSSKTRGVEWKRPSELVDDPQFIVGGATRTDICQGALGDCWLL
CAN2_BOVIN      ------------------------------------------------------------
CAN2_PIG        ------------------------------------------------------------
CAN2_HUMAN      PSFPAIPSALGFKELGPYSSKTRGMRWKRPTEICADPQFIIGGATRTDICQGALGDCWLL
CAN2_RABIT      ------------------------------------------------------------
CAN2_MOUSE      PSFPALPSSLGYKELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLL
CAN2_RAT        PSFPALPSSLGFKELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLL
CAN2_CHICK      PSFPAGPAALGYRELGPNSYKTKGVVWCRPTELCSCPRFIAGGATRTDICQGALGDCWLL
CAN_DROME       SLFEDPLFPASNESLQFSRRPDRHIEWLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLL
CAN_SCHMA       TLWEDPDFPANDKAIGNLPDFRERIEWKRPHEINPNAKFFAGGASRFDIEQGALGDCWLL
SORC_HUMAN      ------------------------------------------------------------
SORC_CRILO      ------------------------------------------------------------
GRAN_HUMAN      ------------------------------------------------------------
SORC_SCHJA      ------------------------------------------------------------
ALG2_MOUSE      ------------------------------------------------------------
                                                                            

CAN3_BOVIN      ------------------------------------------------------------
CAN3_PIG        ------------------------------------------------------------
CAN3_RAT        CLPTYNNQLVFTKSNHRNEFWSAL-LEKAYAKLHGSYEALKGGNTTEAMEDFTGGVT--E
CAN3_MOUSE      CLPTYNNQLVFTKSNHRNEFWSAL-LEKAYAKLHGSYEALKGGNTTEAMEDFTGGVT--E
CAN3_HUMAN      CLPTYNNQLVFTKSNHRNEFWSAL-LEKAYAKLHGSYEALKGGNTTEAMEDFTGGVA--E
CAN3_CHICK      CLPTYNNQLVFTKSSQRNEFWSAL-LEKAYAKLHGSYEALKGGNTTEAMEDFTGGVI--E
CANS_HUMAN      ------------------------------------------------------------
CANS_PIG        ------------------------------------------------------------
CANS_BOVIN      ------------------------------------------------------------
CANS_RABIT      ------------------------------------------------------------
CANS_RAT        ------------------------------------------------------------
CAN1_BOVIN      ------------------------------------------------------------
CAN1_PIG        ------------------------------------------------------------
CAN1_HUMAN      AAIASLTLNDTLLHRVVPHGQSFQ-NGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGK--L
CAN1_RABIT      ------------------------------------------------------------
CANX_CHICK      AAIGSLTLNEELLHRVVPHGQSFQ-EDYAGIFHFQIWQFGEWVDVVVDDLLPTKDGE--L
CAN2_BOVIN      ------------------------------------------------------------
CAN2_PIG        ------------------------------------------------------------
CAN2_HUMAN      AAIASLTLNEEILARVVPLNQSFQ-ENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGE--L
CAN2_RABIT      ------------------------------------------------------------
CAN2_MOUSE      AAIASLTLNEEILARVVPPDQSFQ-ENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGE--L
CAN2_RAT        AAIASLTLNEEILARVVPLDQSFQ-ENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGE--L
CAN2_CHICK      AAIASLTLNEEILARVVPRDQSFQ-DEYAGIFHFQFWQYGEWVDVVVDDRLPTKNGE--L
CAN_DROME       AATANLTQESNLFFRVIPAEQSFE-ENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGE--L
CAN_SCHMA       AVVASISGYPQLFDQVVPKDQELKGPEYVGVVRFRFWRFGHWVEVLIDDRLPVRQGRNTL
SORC_HUMAN      ------------------------------------------------------------
SORC_CRILO      ------------------------------------------------------------
GRAN_HUMAN      ------------------------------------------------------------
SORC_SCHJA      ------------------------------------------------------------
ALG2_MOUSE      ------------------------------------------------------------
                                                                            

CAN3_BOVIN      ----------------------------------------PSGLNMGELIERMVRNMDNS
CAN3_PIG        ----------------------------------------PSGLNMGDLIARMVRNMDES
CAN3_RAT        FFEIKDAPSDMYKIMRKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNS
CAN3_MOUSE      FFEIKDAPSDMYKIMRKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNS
CAN3_HUMAN      FFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNS
CAN3_CHICK      FYEIKDAPKDIYKIMKHAIARGSLMASSIDDNLGFHYGAAPRS-DIGELIARMVKNLENA
CANS_HUMAN      ------------------------------------------------------------
CANS_PIG        ------------------------------------------------------------
CANS_BOVIN      ------------------------------------------------------------
CANS_RABIT      ------------------------------------------------------------
CANS_RAT        ------------------------------------------------------------
CAN1_BOVIN      ------------------------------------------------------------
CAN1_PIG        ------------------------------------------------------------
CAN1_HUMAN      VFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLY
CAN1_RABIT      ------------------------------------------------------------
CANX_CHICK      LFVHSAECTEFWSALLEKAYAKLNGCYESLSGGSTTEGFEDFTGGVAEMYDLKRAPRNMG
CAN2_BOVIN      ------------------------------------------------------------
CAN2_PIG        ------------------------------------------------------------
CAN2_HUMAN      LFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLF
CAN2_RABIT      ------------------------------------------------------------
CAN2_MOUSE      LFVHSAEGSEFWSALLEKAYAKINGCYETLSGGATTEGFEDFTGGIAEWYELRKPPPNLF
CAN2_RAT        LFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELRKPPPNLF
CAN2_CHICK      LFVHSAEGSEFWSALLEKAYAKLNGSYEALSGGTTTEGFEDFTGGIAEWYELQKAPPNLF
CAN_DROME       MYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNLF
CAN_SCHMA       VFMHSNDPTEFWSALLEKAYAKLNGCYAHLSGGSQSEAMEDLTGGICLSLELNQKERPSD
SORC_HUMAN      ------------------------------------------------------------
SORC_CRILO      ------------------------------------------------------------
GRAN_HUMAN      ------------------------------------------------------------
SORC_SCHJA      ------------------------------------------------------------
ALG2_MOUSE      ------------------------------------------------------------
                                                                            

CAN3_BOVIN      RLRDSDLIPEVSDDRPTR---MIVPVQFETRMACGLVKGHAYSVTGLEEALYKGEKVKLV
CAN3_PIG        RLRDSDLIPEVSDDRPTR---TIVPVQFETRMACGLVKGHAYSVTGLEEALFKGEKVKLV
CAN3_RAT        LLRDSDLDPRASDDRPSR---TIVPVQYETRMACGLVKGHAYSVTGLEEALFKGEKVKLV
CAN3_MOUSE      LLRDSDLDPRGSDDRPSR---TIVPVQYETRMACGLVKGHAYSVTGLEEALFKGEKVKLV
CAN3_HUMAN      LLQDSDLDPRGSDERPTR---TIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLV
CAN3_CHICK      QMTYSTVDYQGTDERPAW---TIMPMQYETRMSCGLVKGHAYSVTAVEETTYKGEKMRLV
CANS_HUMAN      ------------------------------------------------------------
CANS_PIG        ------------------------------------------------------------
CANS_BOVIN      ------------------------------------------------------------
CANS_RABIT      ------------------------------------------------------------
CANS_RAT        ------------------------------------------------------------
CAN1_BOVIN      ------------------------------------------------------------
CAN1_PIG        ------------------------------------------------------------
CAN1_HUMAN      QIILKALERGSLLGCSID---ISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLI
CAN1_RABIT      ------------------------------------------------------------
CANX_CHICK      HIIRKALERGSLLGCSID---ITSAFDMEAVTFKKLVKGHAYSVTAFKDVNYRGQQEQLI
CAN2_BOVIN      ------------------------------------------------------------
CAN2_PIG        ------------------------------------------------------------
CAN2_HUMAN      KIIQKALQKGSLLGCSID---ITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLI
CAN2_RABIT      --------------------------------------------------------QKLI
CAN2_MOUSE      KIIQKALEKGSLLGCSID---ITSAADSEAVTYQKLVKGHAYSVTGAEEVESSGSLQKLI
CAN2_RAT        KIIQKALEKGSLLGCSID---ITSAADSEAVTYQKLVKGHAYSVTGAEEVESSGSLQKLI
CAN2_CHICK      KIIQKALQKGSLLGCSID---ITSAAETEAVTSQKLVKGHAYSVTGAEEVNFRGSIQKLI
CAN_DROME       TILQKAAERNSMMGCSIEPDPNVTEAETPQGLIRGHAYSITKVCLIDIVTPNRQGKIPMI
CAN_SCHMA       LIDQLKIYAQRCCLMGCS----IDSSVMEQKMDNGLIGSHAYSLTGVYPVNYRGRTQWLM
SORC_HUMAN      ------------------------------------------------------------
SORC_CRILO      ------------------------------------------------------------
GRAN_HUMAN      ------------------------------------------------------------
SORC_SCHJA      ------------------------------------------------------------
ALG2_MOUSE      ------------------------------------------------------------
                                                                            

CAN3_BOVIN      RLRNPWG-QVEWNGSWSDSWKDWSYVDKDEKARLQHQVTE--------------------
CAN3_PIG        RLRNPWG-QVEWNGSWSDSWKDWSFVDKDEKARLQHQVTEDGEFWMSYDDFIYHFTKLEI
CAN3_RAT        RLRNPWG-QVEWNGSWSDGWKDWSFVDKDEKARLQHQVTEDGEFWMSYDDFVYHFTKLEI
CAN3_MOUSE      RLRNPWG-QVEWNGSWSDGWKDWSFVDKDEKARLQHQVTEDGEFWMSYDDFVYHFTKLEI
CAN3_HUMAN      RLRNPWG-QVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEI
CAN3_CHICK      RLRNPWG-QVEWNGPWSDKSEEWNFIDEEEKIRLQHKIAEDGEFWISLEDFMRHFTKLEI
CANS_HUMAN      ------------------------------------------------------------
CANS_PIG        ------------------------------------------------------------
CANS_BOVIN      ------------------------------------------------------------
CANS_RABIT      ------------------------------------------------------------
CANS_RAT        ------------------------------------------------------------
CAN1_BOVIN      ------------------------------------------------------------
CAN1_PIG        ------------------------------------------------------------
CAN1_HUMAN      RMRNPWG-EVEWTGAWSDSSSEWNNVDPYERDQLRVKM-EDGEFWMSFRDFMREFTRLEI
CAN1_RABIT      ------------------------------------------------------------
CANX_CHICK      RIRNPWG-QVEWTGAWSDGSSEWDNIDPSDREELQLKM-EDGEFWMSFRDFMREFSRLEI
CAN2_BOVIN      ------------------------------------------------------------
CAN2_PIG        ------------------------------------------------------------
CAN2_HUMAN      RIRNPWG-EVEWTGRWNDNCPSWNTIDPEERERLTRRH-EDGEFWMSFSDFLRHYSRLEI
CAN2_RABIT      RIRNPWG-EVEWTGRWNDNCPNWNTVDPEVRERLAERH-EDGEFWMSFSDFLRHYSRLEI
CAN2_MOUSE      RIRNPWG-QVEWTGKWNDNCPSWNTVDPEVRANLTERQ-EDGEFWMSFSDFLRHYSRLEI
CAN2_RAT        RIRNPWG-QVEWTGKWNDNCPSWNTVDPEVRANLTERQ-EDGEFWMSFSDFLRHYSRLEI
CAN2_CHICK      RIRNPWG-EVEWTGKWNDNCPNWSGVDPEVRERLTRRH-EDGEFWMAFNDFLRHYSRLEI
CAN_DROME       RMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEI
CAN_SCHMA       RLRNPWGDSHEWKGAWCDGSPQWREISEQEKKNINLSFTADGEFWMSYEDFVTCFSRVEV
SORC_HUMAN      ------------------------------------------------------------
SORC_CRILO      ------------------------------------------------------------
GRAN_HUMAN      ------------------------------------------------------------
SORC_SCHJA      ------------------------------------------------------------
ALG2_MOUSE      ------------------------------------------------------------
                                                                            

CAN3_BOVIN      ------------------------------------------------------------
CAN3_PIG        CNLTADALESDKL----QTWTVSVNEGRWVRGCSAGTGRNFPDTFWTNPQYRLKLLEEDD
CAN3_RAT        CNLTADALESDKL----QTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDD
CAN3_MOUSE      CNLTADALESDKL----QTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDD
CAN3_HUMAN      CNLTADALQSDKL----QTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDD
CAN3_CHICK      CNLTPDTLEADKL----QTWTVSVNEGRWVRGCSAGGCRNYPDTFWTNPQYRLKLLEEDD
CANS_HUMAN      ------------------------------------------------------------
CANS_PIG        ------------------------------------------------------------
CANS_BOVIN      ------------------------------------------------------------
CANS_RABIT      ------------------------------------------------------------
CANS_RAT        ------------------------------------------------------------
CAN1_BOVIN      ------------------------------------------------------------
CAN1_PIG        ------------------------------------------------------------
CAN1_HUMAN      CNLTPDALKSRTI----RKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDD
CAN1_RABIT      ------------------------------------------------------------
CANX_CHICK      CNLTPDALTKDEL----SRWHTQVFEGTWRRGSTAGGCRNNPATFWINPQFKIKLLEEDD
CAN2_BOVIN      ----------------------------------------YPNTFWMNPQYLIKLEEEDE
CAN2_PIG        ----------------------------------------YPNTFWMNPQYLIKLEEEDE
CAN2_HUMAN      CNLTPDTLTSDTY----KKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDE
CAN2_RABIT      CNLTPDTLTSDTY----KKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYVIKLEEEDE
CAN2_MOUSE      CNLTPDTLTCDSY----KKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDE
CAN2_RAT        CNLTPDTLTCDSY----KKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDE
CAN2_CHICK      CNLTPDTLASDRY----KKWSLLKLDGNWRRGATAGGCRNYPNTFWTNPQYLIKLEEEDE
CAN_DROME       CNLSPDSLTEDQQHSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLVDPDE
CAN_SCHMA       CHLGLESLEYNQNFHGKRRLDEAIFSGQWQRNVNAGGCINNRTTYWTSPQFRITVEDPDP
SORC_HUMAN      ------------------------------------------------------------
SORC_CRILO      ------------------------------------------------------------
GRAN_HUMAN      ------------------------------------------------------------
SORC_SCHJA      ------------------------------------------------------------
ALG2_MOUSE      ------------------------------------------------------------
                                                                            

CAN3_BOVIN      ------------------------------------------------------------
CAN3_PIG        --DPDDSEVICSFLVALMQRNRRKDRKLGANLFTIGFAIYEVPKEMHGNKQ-HLQKDFFL
CAN3_RAT        --DPDDSEVICSFLVALMQKNRRKDRKLGANLFTIGFAIYEVPKEMHGNKQ-HLQKDFFL
CAN3_MOUSE      --DPEDSEVICSFLVALMQKNRRKDRKLGANLFTIGFAIYEVPKEMHGNKQ-HLQKDFFL
CAN3_HUMAN      --DPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQ-HLQKDFFL
CAN3_CHICK      --DPEDEEVICSFLVALMQKNRRKERKLGANLYTIGFAIYEVPKEMHGTKH-HLQKDFFL
CANS_HUMAN      ------------------------------------------------------------
CANS_PIG        ------------------------------------------------------------
CANS_BOVIN      ------------------------------------------------------------
CANS_RABIT      ------------------------------------------------------------
CANS_RAT        ------------------------------------------------------------
CAN1_BOVIN      ------------------------------------------------------------
CAN1_PIG        -------------------------------RVRMEDGEFWMSFRDXLREFTRLEICNLT
CAN1_HUMAN      PDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFL
CAN1_RABIT      ------RESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPRELVGQPALHLKRDFFL
CANX_CHICK      --DPGDDEVACSFLVALMQKHRRRERRVGGDMHTIGFAVYEVPEEAQGSQNVHLKKDFFL
CAN2_BOVIN      --DQEDGESGCTFLVGLIQKHRQRQRKMGEDMHTIGFGIYEVPEELTGQTNIHLSKKFFL
CAN2_PIG        --DQEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELTGQTNIHLSKNFFL
CAN2_HUMAN      --DEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFL
CAN2_RABIT      --DQEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELRGQTNIHLGKNFFL
CAN2_MOUSE      --DEEDGGRGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELTGQTNIHLGKNFFL
CAN2_RAT        --DDEDGERGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELTGQTNIHLSKNFFL
CAN2_CHICK      --DPDDPEGGCTFLIGLIQKHRRKQRKMGEDMHTIGFAIYEVPPEFSGQTNIHLSKNFFL
CAN_DROME       ----EDEEGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRP--QGLNFFR
CAN_SCHMA       ----DDDDNKCSVLIGLMQTDIR--KKVGADFQPIGFMVYNAPDDLNTLLS-----RAQL
SORC_HUMAN      ------------------------------------------------------------
SORC_CRILO      ------------------------------------------------------------
GRAN_HUMAN      ------------------------------------------------------------
SORC_SCHJA      ------------------------------------------------------------
ALG2_MOUSE      ------------------------------------------------------------
                                                                            

CAN3_BOVIN      ------------------------------------------------------------
CAN3_PIG        YNASKARSRTYINMREVSERFRLPPSEYVIVPSTYEPHQEGEFMLRVFSEKRKLSEEVEN
CAN3_RAT        YNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEAEN
CAN3_MOUSE      YNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEAEN
CAN3_HUMAN      YNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVEN
CAN3_CHICK      YNASKARSKTYINMREISERFRLPPSEYVIIPSTYEPHQEGEFILRVFSEKRSLSEEVEN
CANS_HUMAN      ---------------------------MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLI
CANS_PIG        ---------------------------MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLI
CANS_BOVIN      ---------------------------MFLVNSFLKGGGGGGGGGG-LGGGLGNVLGGLI
CANS_RABIT      ---------------------------MFLVNSFLKGGGGGGGGGG-LGGGLGNVLGGLI
CANS_RAT        ------------------------------------------------------------
CAN1_BOVIN      ------------------------------------------------------------
CAN1_PIG        PDALKSQRVRNWXTTLYEGTWRRGSTAXGCRNYPATFWVNPQFKIRLEETDDPEDDYGGR
CAN1_HUMAN      ANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDD
CAN1_RABIT      ANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKRAGTQELDD
CANX_CHICK      RNQSRARSETFINLREVSNQIRLPPGEYIVVPSTFEPHKEADFILRVFTEKQSDTAELDE
CAN2_BOVIN      TTRARD-VDTFINLRRCSTASSCPP-EYIVVPSTFEPNKDGDFCIRVFSEKKADYQVVDD
CAN2_PIG        THRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQVVDD
CAN2_HUMAN      TNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDD
CAN2_RABIT      TTRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKNGDFCVRVFSEKKADYQAVDD
CAN2_MOUSE      TTRARERSDTFINLREVLNRFKLPPGEYVLVPSTFEPHKDGDFCIRVFSEKKADYQAVDD
CAN2_RAT        TTRARERSDTFINLREVLNRFKLPPGEYVLVPSTFEPHKNGDFCIRVFSEKKADYQTVDD
CAN2_CHICK      TNKAREKSNTFINLREVLNRFKLPAGEYIIVPSTFEPNLNGDFCLRVFSEKNANSTVIDD
CAN_DROME       YKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDD
CAN_SCHMA       LTRSPIAKSQFINTREVTAQFRVPPGSYVVIPSTFDPNIEVNFILRVFSQTSITEQELDE
SORC_HUMAN      ------------------------------MAYPGHPGAGGGY----YPGGYGGAPGGPA
SORC_CRILO      ------------------------------MAYPGHPGAGGGY----YPGGYGGAPGGPS
GRAN_HUMAN      ------------------------------MAYPGYGGGFGNFSIQ-VPGMQMGQPVPET
SORC_SCHJA      ------------------------------------------------------------
ALG2_MOUSE      -----------------------------MAAYSYRPGPGGGP---------GP-AAGAA

                                                                            

CAN3_BOVIN      ------------------------------------------------------------
CAN3_PIG        TISVDRPVRKKKTKPIIFVSDRANSNKELGVDQESEEGQDKTSPDKQEKSPKP-------
CAN3_RAT        TISVDRPVKKKKNKPIIFVSDRANSNKELGVDQEAEEGKDKTGPDKQGESPQP-------
CAN3_MOUSE      TISVDRPVKKKKNKPIIFVSDRANSNKELGVDQEAEEGKDKAGPEKRGETPQP-------
CAN3_HUMAN      TISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQP-------
CAN3_CHICK      MIEADRPSKKKKGKPIIFVSDRANSNKELTTDEDAGKDGEKTHVDEKKRS----------
CANS_HUMAN      SGAGGGGGGGGGGGGGGGGGGGGTAMRILGGVISAISEAAAQYNPEPPPPRTH-------
CANS_PIG        SGAGGGGGGGGGGGGGGGGGG--TAMRILGGVISAISEAAAQYNPEPPPPRTH-------
CANS_BOVIN      SGAGGGGGGGGGGGGGGGGTA----MRILGGVISAISEAAAQYNPEPVPPRTH-------
CANS_RABIT      SGAGGGGGGGGGGGGGGAGGGG-TAMRILGGVISAISEAAAQYNPEPPPPRTH-------
CANS_RAT        ---------------------------------------------------MH-------
CAN1_BOVIN      -IQANLP-----------------------------------------------------
CAN1_PIG        EIQANLP-----------------------------------------------------
CAN1_HUMAN      QIQANLP-----------------------------------------------------
CAN1_RABIT      QIQANLP-----------------------------------------------------
CANX_CHICK      EISADLA-----------------------------------------------------
CAN2_BOVIN      EIEANI------------------------------------------------------
CAN2_PIG        EIEADL------------------------------------------------------
CAN2_HUMAN      EIEANL------------------------------------------------------
CAN2_RABIT      EIEADL------------------------------------------------------
CAN2_MOUSE      EIEANI------------------------------------------------------
CAN2_RAT        EIEANI------------------------------------------------------
CAN2_CHICK      EIEANF------------------------------------------------------
CAN_DROME       HVGYGGKADTITPGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELKRILDHSMRDDLP
CAN_SCHMA       DNTNQGL---------------------------------------PDDVIEA-------
SORC_HUMAN      FPG---------------------------------------------------------
SORC_CRILO      FPG---------------------------------------------------------
GRAN_HUMAN      GPAILLD----------------G--------------------------YSG-------
SORC_SCHJA      ------------------------------------------------------------
ALG2_MOUSE      LPD---------------------------------------------------------

CAN3_BOVIN      ------------------------------------------------------------
CAN3_PIG        -------------EPSNTDQESEEQ-----------------------------------
CAN3_RAT        -------------RPGHTDQESEEQQQFRNIFRQI-AGDDMEICADELKNVLNTVVNKHK
CAN3_MOUSE      -------------RPGHTDQESEEQQQFRNIFRQI-AGDDMEICADELKNVLNTVVNKHK
CAN3_HUMAN      -------------QPGSSDQESEEQQQFRNIFKQI-AGDDMEICADELKKVLNTVVNKHK
CAN3_CHICK      --------------SAKAREKSEEETQFRNIFRQI-AGDDMEICREELRNVLNNVVKKHK
CANS_HUMAN      -------------YSNIEANESEEVRQFRRLFAQL-AGDDMEVSATELMNILNKVVTRHP
CANS_PIG        -------------YSNIEANESEEVRQFRRLFAQL-AGDDMEVSATELMNILNKVVTRHP
CANS_BOVIN      -------------YSNIEANESEEVRQFRRLFAQL-AGDDMEVSATELMNILNKVVTRHP
CANS_RABIT      -------------YSNIEANESEEVRQFRRLFAQL-AGDDMEVSATELMNILNKVVTRHP
CANS_RAT        -------------YSNIEANESEEERQFRKLFVQL-AGDDMEVSATELMNILNKVVTRHP
CAN1_BOVIN      --------------DEQVLSEEEIDENFKSLFRQL-AGEDMEISVKELRTILNRIISKHK
CAN1_PIG        --------------DEQVLSEGEIDENFKALFRQL-AGEDMEISVRELRTILNRIISKHK
CAN1_HUMAN      --------------DEQVLSEEEIDENFKALFRQL-AGEDMEISVKELRTILNRIISKHK
CAN1_RABIT      --------------DEQVLSAEEIDENFKALFRQL-AGEDLEISVRELQTILNRITSKHK
CANX_CHICK      --------------DEEEITEDDIEDGFKNMFQQL-AGEDMEISVFELKTILNRVIARHK
CAN2_BOVIN      --------------DEIDISEDDIDDGFRRLFAQL-AGEDAEISAFELQTILRRVLAKRQ
CAN2_PIG        --------------EENDASEDDIDDGFRRLFAQL-AGEDAEISAFELQTILRRVLAKRQ
CAN2_HUMAN      --------------EEFDISEDDIDDGVRRLFAQL-AGEDAEISAFELQTILRRVLAKRQ
CAN2_RABIT      --------------EEADVSEDDIDDGFRRLFAQL-AGEDAEISAFELQNILRRVLAKRQ
CAN2_MOUSE      --------------EEIDANEEDIDDGFRRLFVQL-AGEDAEISAFELQTILRRVLAKRQ
CAN2_RAT        --------------EEIEANEEDIGDGFRRLFAQL-AGEDAEISAFELQTILRRVLAKRE
CAN2_CHICK      --------------EETEIDEDDIEPSFKKLFGQL-AGSDAEISAFELRSILNKILAKRQ
CAN_DROME       KPVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLI-CGPFLKGTPFEEQLGMNDQSNKRL
CAN_SCHMA       -------------LKLEDTLLDEDQEIEQKFLAIR-DPKTNAINAVKLGELLNNSTLQDI
SORC_HUMAN      ----------------------QTQDPLYGYFAAV-AGQDGQIDADELQRCLTQSGIAGG
SORC_CRILO      ----------------------QTQDPLYGYFASV-AGQDGQIDADELQRCLTQSGIAGG
GRAN_HUMAN      --------------PAYSDTYSSAGDSVYTYFSAV-AGQDGEVDAEELQRCLTQSGINGT
SORC_SCHJA      --------------------MVMDTNSLRHIFSRVDADKSGSISANELQTSL--S--NGL
ALG2_MOUSE      ----------------------Q--SFLWNVFQRVDKDRSGVISDNELQQAL--S--NGT



CAN3_BOVIN      ------------------------------------------------------------
CAN3_PIG        ------------------------------------------------------------
CAN3_RAT        DLKTQ----------------GFTLESCRSMIALMDTDGSGRLNLQEFHHLWKKIKAWQK
CAN3_MOUSE      DLKTQ----------------GFTLESCRSMIALMDTDGSGRLNLQEFHHLWKKIKAWQK
CAN3_HUMAN      DLKTH----------------GFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQK
CAN3_CHICK      DLKTE----------------GFELESSRSMIALMDTDGSGKINFDEFRHLWDKIKSWQK
CANS_HUMAN      DLKTD----------------GFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQA
CANS_PIG        DLKTD----------------GFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQA
CANS_BOVIN      DLKTD----------------GFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQA
CANS_RABIT      DLKTD----------------GFGLDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQA
CANS_RAT        DLKTD----------------GFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQG
CAN1_BOVIN      DCGPRL---------------QPGVLPQHGQPHGSRRQWQTGPGGVQHPM--ERIRNYLA
CAN1_PIG        DLRTK----------------GFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLA
CAN1_HUMAN      DLRTK----------------GFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLS
CAN1_RABIT      DLRTK----------------GFSMESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLA
CANX_CHICK      DLKTD----------------GFSLDSCRNMVNLMDKDGSARLGLVEFQILWNKIRSWLT
CAN2_BOVIN      DIKSD----------------GFSIETCKIMVDMLD------------------------
CAN2_PIG        DIKSD----------------GFSIETCRIMVDMLDSDGSAKLGLKEFYILWTKIQKYQK
CAN2_HUMAN      DIKSD----------------GFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQK
CAN2_RABIT      DIKTD----------------GLSIETCKIMVDMLDSDGTGKLGLKEFYVLWTKIQKYQK
CAN2_MOUSE      DIKSD----------------GFSIETCKIMVDMLDEDGSGKLGLKEFYILWTKIQKYQK
CAN2_RAT        DIKSD----------------GFSIETCKIMVDMLDEDGSGKLGLKEFYILWTKIQKYQK
CAN2_CHICK      DIKSD----------------GFSIETCKIMVDLLDNDGSGKLGLKEFHTLWTKIQKYQK
CAN_DROME       IGDNPADGGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKA
CAN_SCHMA       PNFQG-----------------FNKELCRSMVASVDNNLTGHVELNEFMDLWIQAKGWKH
SORC_HUMAN      YKPFN-------------------LETCRLMVSMLDRDMSGTMGFNEFKELWAVLNGWRQ
SORC_CRILO      YKPFN-------------------LETCRLMVSMLDRDMSGTMGFNEFKELWAVLNGWRQ
GRAN_HUMAN      YSPFS-------------------LETCRIMIAMLDRDHTGKMGFNAFKELWAALNAWKE
SORC_SCHJA      GTPLN-------------------IRTVQLMVAMFDRDMNGTINFNEFLGLFKYVQDWQT
ALG2_MOUSE      WTPFN-------------------PVTVRSIISMFDRENKAGVNFSEFTGVWKYITDWQN

 

CAN3_BOVIN      ------------------------------------------------------------
CAN3_PIG        ------------------------------------------------------------
CAN3_RAT        IFKHYDTDHSGTINSYEMRNAVNDAGFHLNSQLYDIITMRYADKHM-NIDFDSFICCFVR
CAN3_MOUSE      IFKHYDTDHSGTINSYEMRNAVNDAGFHLNSQLYDIITMRYADKHM-NIDFDSFICCFVR
CAN3_HUMAN      IFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHM-NIDFDSFICCFVR
CAN3_CHICK      IFKHYDADHSGTINSYEMRNAVKDAGFRLNNQLYDIITMRYADKNM-NIDFDSFICCFVR
CANS_HUMAN      IYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESG-NMDFDNFISCLVR
CANS_PIG        IYKQFDVDRSGTIGSSELPGAFEAAGFHLNEHLYSMIIRRYSDEGG-NMDFDNFISCLVR
CANS_BOVIN      VYKQFDVDRSGTIGSSELPGAFEAAGFRLNEHLYNMIIRRYSDEGG-NMDFDNFISCLVR
CANS_RABIT      IYKQFDVDRSGTICSRELPGAFEAAGFHLNEHLYNMIIRRYSDEAG-NMDFDNFISCLVR
CANS_RAT        IYKRFDTDRSGTIGSNELPGAFEAAGFHLNQHIYSMIIRRYSDETG-NMDFDNFISCLVR
CAN1_BOVIN      I-----------------------------------------------------------
CAN1_PIG        I-----------------------------------------------------------
CAN1_HUMAN      IFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDL-AVDFDNFVCCLVR
CAN1_RABIT      IFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDL-AVDFDNFVCCLVR
CANX_CHICK      IFRQYDLDKSGTMSSYEMRMALESAGFKLNNKLHQVVVARYADAET-GVDFDNFVCCLVK
CAN2_BOVIN      ------------------------------------------------------------
CAN2_PIG        IYREIDVDRSGTMNSYEMRKALEEAGFKLPCQLHQVIVARFADDQL-IIDFDNFVRCLVR
CAN2_HUMAN      IYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQL-IIDFDNFVRCLVR
CAN2_RABIT      IYREIDVDRSGTMNSYEMRKALEEAGFKLPCQLHEVIVARFADDQL-IIDFDNFVRCLVR
CAN2_MOUSE      IYREIDVDRSGTMNSYEMRKALEEAGFKLPCQLHQVIVARFADDEL-IIDFDNFVRCLVR
CAN2_RAT        IYREIDVDRSGTMNSYEMRKALEEAGFKLPCQLHQVIVARFADDEL-IIDFDNFVRCLVR
CAN2_CHICK      IYREIDVDRSGTMNSYEMRRALEAAGFKLSCQLHQIIVARFADEDL-IIDFDNCVRCLIR
CAN_DROME       IFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDG-KIAFDDFIMCAVK
CAN_SCHMA       IFIKHDVDQSGYFSAYEFREALNDAGYHVSNRLINAIINRYQDPGTDKISFEDFMLCMVR
SORC_HUMAN      HFISFDTDRSGTVDPQELQKALTTMGFRLSPQAVNSIAKRYSTN--GKITFDDYIACCVK
SORC_CRILO      HFISFDSDRSGTVDPQELQKALTTMGFRLNPQTVNSIAKRYSTS--GKITFDDYIACCVK
GRAN_HUMAN      NFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSKN--GRIFFDDYVACCVK
SORC_SCHJA      CFRRYDRDNSGSIDLNEFSNALISFGYHLSPQFVNLMMRRFDRN-RGSIAFDDFIYACVC
ALG2_MOUSE      VFRTYDRDNSGMIDKNELKQALSGFGYRLSDQFHDILIRKFDRQGRGQIAFDDFIQGCIV



CAN3_BOVIN      -----------------------------------
CAN3_PIG        -----------------------------------
CAN3_RAT        LEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA--
CAN3_MOUSE      LEGMFRAFNAFDKDGDGIIKLNVLEWLQLTMYA--
CAN3_HUMAN      LEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA--
CAN3_CHICK      LDAMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA--
CANS_HUMAN      LDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS--
CANS_PIG        LDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS--
CANS_BOVIN      LDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS--
CANS_RABIT      LDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS--
CANS_RAT        LDAMFRAFRSLDKNGTGQIQVNIQEWLQLTMYS--
CAN1_BOVIN      -----------------------------------
CAN1_PIG        -----------------------------------
CAN1_HUMAN      LETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA--
CAN1_RABIT      LETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA--
CANX_CHICK      LETMFRFFHSMDRDGTGTAVMNLAEWLLLTMCG--
CAN2_BOVIN      -----------------------------------
CAN2_PIG        LETLFRISKQLDSENTGTIELDLISWLCFSVL---
CAN2_HUMAN      LETLFKIFKQLDPENTGTIELDLISWLCFSVL---
CAN2_RABIT      LETLFKIFKQLDPDNTGMIQLDLISWLCFSVL---
CAN2_MOUSE      LETLFKIFKQLDPENTGTIQLNLASWLSFSVL---
CAN2_RAT        LEILFKIFKQLDPENTGTIQLDLISWLSFSVL---
CAN2_CHICK      LETLYKMFRKLDTEKTGTIELNLINWLFFTVI---
CAN_DROME       IKTYIDIFKERDTEKNETATFTLEEWIERTIYS--
CAN_SCHMA       LKTAFETIEAHPKNIEGTSLFSAEDYLRFSVYI--
SORC_HUMAN      LRALTDSFRRRDTAQQGVVNFPYDDFIQCVMSV--
SORC_CRILO      LRALTDSFRRRDSAQQGMVNFSYDDFIQCVMTV--
GRAN_HUMAN      LRALTDFFRKRDHLQQGSANFIYDDFLQGTMAI--
SORC_SCHJA      LQTLTREFSRYDCRGIGHTVFSFEQFLTSAFAVII
ALG2_MOUSE      LQRLTDIFRRYDTDQDGWIQVSYEQYLSMVFSIV-


Protein Codes:

ALG2 = ALG-2; CAN = calpain large subunit, lower animal isoform; CAN1 = calpain large subunit, isoform I; CAN2 = calpain large subunit, isoform II; CAN3 = calpain large subunit, isoform III; GRAN = grancalcin; SORC = sorcin



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