Distance Differences in the Helix II/III Interface of the Myosin Essential Light Chain Domains

Analysis of the Differences between the Two Domains of Myosin Essential Light Chain: The II/III Interhelical Interface

A comparison of the II/III interhelical interface of the N- and C-terminal domains of the myosin essential light chain: Interhelical distance difference matrix (DDM) entries are mapped onto a ribbon representation of myosin ELC-N. Residues that are moderately closer together in ELC-N (DD between -2 and -5 angstroms) are connected by light blue lines. Residues that are much closer together in ELC-N (DD less than -5 angstroms) are connected by dark blue lines. Residues that are moderately closer together in ELC-C (DD between 2 and 5 angstroms) are connected by light pink lines. Residues that are much closer together The helices were rendered as ribbons using InsightII (MSI, San Diego, CA), and the DDs and contacts were rendered as distance restraints using the NMR_Refine module of InsightII. Coordinates are from PDB file 1WDC

This graphic was used as a slide at the 1997 graduate student retreat. There is also a picture showing the distance differences in the III/IV interface, a picture showing the distance differences in the I/II and II/IV interfaces, and a picture showing the distance differences and interhelical contacts in all of the interhelical interfaces of the two domains of the essential light chain.

Details about file locations and color scheme. Internal access only