Department of Biochemistry
Robinson Research Building
Room 868A
Vanderbilt University
School of Medicine
Nashville, Tennessee 37232-0146
Egli Laboratory
Structural and Chemical Biology
Tel: 615.343.8070
Fax: 615.322.7122
martin.egli@vanderbilt.edu

Lab Members
Research
Publications
Open Positions

Martin Egli (Principal Investigator)


Professional Appointments
  • 2005-Present: Professor, Dept. of Biochemistry, Vanderbilt University, School of Medicine, Nashville, Tennessee
  • 2000-2005: Associate Professor, Dept. of Biological Sciences/Dept. of Biochemistry, Vanderbilt University, Nashville, Tennessee
  • 1995-2000: Assistant Professor, Dept. of Molecular Pharm. & Biological Chem. Member, Drug Discovery Program and Robert H. Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL.
  • 1992-1995: Lecturer and Habilitand, Laboratory of Organic Chemistry, Swiss Federal Institute of Technology (ETH), Zurich, Switzerland
Education
  • 1989-1992 Postdoctoral fellow, Alexander Rich, Dept. of Biology, M.I.T., Cambridge MA, U.S.A.
  • 1986-1988 Ph.D Thesis, Laboratory of Organic Chemistry, ETH-Zurich
    • Advisors: Vladimir Prelog (Nobel laureate, Chemistry, 1975; died 1998), Jack D. Dunitz (Prof. emer.), Max Dobler (Prof. emer.)
  • 1984 Diploma, Dept. of Chemistry, ETH-Zurich. Advisor: Jack D. Dunitz
  • 1980-1984 Undergraduate, Dept. of Chemistry, ETH-Zurich
Teaching

2000 - Present: Classes Taught at Vanderbilt:
  • "Protein design" (Seniors, enrollment 20-30)
  • "Introduction to the biological sciences" (Freshmen, enrollment 200+)
  • "RNA structure and biology" and "X-ray crystallography" (Graduate courses)
1998 - 1999: Director, Northwestern Drug Discovery Program Summer School.
1995 - Present: Participated in courses in the Dept of Molec. Pharmac. & Biolog. Chem, e.g. "Advanced topics in drug discovery" and "Macromolecular structure and function".
1992 - 1995: Teaching organic synthesis lab course for pharmacology undergraduate students, ETH-Zurich.
1990: Instructed sections of an X-ray crystallography course for graduate students at the Dept. of Biology, M.I.T.
1987 - 1988: Supervisor of chemical crystallography course for under- graduate students, Laboratory for Organic Chemistry, ETH-Zurich.

Presentations
  • NIEHS Center, Sealy Center for Environmental Health and Medicine, University of Texas Medical Branch, Galveston, TX, March 29, 2010
  • Dept. of Chemistry, St. Louis University, St. Louis, MO, February 26, 2010
  • Biophysics Program, The Ohio State University, Columbus, OH, January 14, 2010

  • Dept. of Chemical Engineering, Laboratory of Biomacromolecular Structure, Polytechnic University of Catalonia, Barcelona, Spain, November 18, 2009
  • 67th Annual Pittsburgh Diffraction Society Meeting, RNA Structure, Athens, GA, October 29, 2009.
  • INDABA-6, Structure and Properties, Kruger National Park, South Africa, August 30-September 4, 2009.
  • American Chemical Society, 238th National Meeting, Division of Carbohydrate Chemistry, RNA Targeting, Nucleic Acids and Analogs, Washington DC, August 18, 2009.

  • Dept. of Chemistry, The State University of New York at Binghamton, Binghamton, NY, December 5, 2008.
  • Dept. of Drug Discovery, Alnylam Pharmaceuticals Inc., Cambridge, MA, November 11, 2008.
  • Dept. of Chemistry, Wake Forest University, Winston-Salem, NC, November 5, 2008.
  • Dept. of Chemistry and Biochemistry, Concordia University, Montreal, Quebec, Canada, October 3, 2008.
  • American Chemical Society, 236th National Meeting. Philadelphia, PA, Division of Carbohydrate Chemistry, August 19, 2008.

  • American Chemical Society, 234th National Meeting, Protein-Nucleic Acid Interactions: Experimental and Modeling Analysis, Division of Computers in Chemistry, Boston, MA. August 20, 2007.
  • American Chemical Society, 234th National Meeting, Wolfrom/Isbell/New Investigator Award Symposium, Division of Carbohydrate Chemistry, Boston, MA. August 19, 2007.
  • Dept. of Biochemistry, Baylor College of Medicine, Houston, TX, May 3, 2007
  • Vladimir Prelog Memorial Lecture, The Jubilee XX Croatian Meeting of Chemists and Chemical Engineers, Zagreb, Croatia, February 27-March 1, 2007.
  • Laboratory of Molecular Biology, Cambridge University, Cambridge, UK, February 26, 2007.

  • INDABA-5, Models, Mysteries and Magic of Molecules, Kruger National Park, South Africa, August 20-25, 2006.
  • Dept. of Biochemistry, University of Pretoria, Pretoria, South Africa, August 18, 2006.
  • First International Conference on Nanobiomedical Technology and Structural Biology, Chengdu, China, June 25-28, 2006.
  • School of Pharmaceutical Sciences, Nottingham University, Nottingham, UK, May 11, 2006.

  • Dept. of Chemistry, Seoul National University, Seoul, Korea. December 1, 2005.
  • The XX Assembly of the International Union of Crystallography (IUCR Congress). Florence, Italy, August 23-31, 2005
  • Dept. of Chemistry, Georgia State University, Atlanta, GA, April 8, 2005.
  • Dept. of Biochemistry, Tufts University, School of Medicine, Boston, MA, March 17, 2005.

  • Dept. of Life Sciences, Proteomics Center, Korea Institute of Science and Technology, Seoul, Korea, Dec. 27, 2004.
  • Dept. of Chemistry, College of Natural Sciences, Seoul National University, Seoul, Korea, Dec. 21, 2004.
  • The Sixth International Meeting on Recognition Studies in Nucleic Acids (NACON VI). Sheffield, UK, April 4-8, 2004.

  • Dept. of Chemistry, Wake Forest University. Winston-Salem, NC. November 19, 2003.
  • RNA Society of North Carolina. North Carolina State University, Raleigh, NC. November 18, 2003.
  • Workshop on "Neutron Macromolecular Crystallography at the SNS". Argonne National Laboratory, Argonne IL. October 2-3, 2003.
  • International Union of Pure and Applied Chemistry (IUPAC) and Canadian Society for Chemistry (CSC) Conference. Ottawa, Canada. August 10-15, 2003.
  • Albany 2003: The 13th Conversation in Biomolecular Structure and Dynamics. The State University of New York, Albany, NY. June 17-21, 2003.
  • Nucleic Acids Gordon Conference. Nucleic Acid Modifications and Therapeutics Session. Salve Regina University, Newport, RI. June 1-6, 2003.
  • American Chemical Society, 225th - National Meeting. New Orleans, LA. March 23-27, 2003.

  • Dept. of Biochemistry, Vanderbilt University Medical School. Nashville, TN. November 4, 2002.
  • Dept. of Biochemistry, Tufts University Medical School. Boston, MA. October 8, 2002.
  • Dept. of Biology, MIT, Macromolecular Structure & Function Seminar. Cambridge, MA. October 7, 2002.
  • The Seventh International Meeting on RNase H Chemistry and Biology. Tsuruoka, Japan. September 25-28. 2002.
  • The XIX Assembly of the International Union of Crystallography (IUCR Congress). Geneva, Switzerland. August 6-15, 2002.
  • European Symposium on Bio-Organic Chemistry. Gregynog, Powys, Wales, UK. May 10-13, 2002.

  • Dept. of Chemistry, Brooklyn College (CUNY), Brooklyn, NY. September 28, 2001.
  • The Fifth International Meeting on Recognition Studies in Nucleic Acids (NACON V). Sheffield, UK, April 9-12, 2001.

  • The 2000 International Chemical Congress of Pacific Basin Societies. Honolulu, Hawaii. December 14-19, 2000.
  • International Symposium on the Development of New Structural Biology Including Hydrogen Bonding and Hydration. Mito, Ibaraki, Japan. October 27-29, 2000.
  • RNA structure meeting, University of California at Santa Cruz. Santa Cruz, CA. July 12-16, 2000.
  • European Symposium on Bioorganic Chemistry. Gregynog, Powys, Wales, UK. May 12-15, 2000.
  • Dept. of Biology, Massachusetts Institute of Technology. Cambridge, MA. May 1, 2000.
  • Dept. of Biological, Chemical and Physical Sciences, Illinois Institute of Technology. Chicago, IL. April 24, 2000.
  • Robert H. Lurie Cancer Center Seminar Series, Northwestern University. Chicago, IL. January 5, 2000.

  • School of Chemistry, University of Birmingham, Birmingham, UK. October 12, 1999.
  • American Chemical Society, 218th National Meeting, New Orleans, LA. August 25, 1999.
  • Gordon Research Conference, Purines, Pyrimidines and Related Substances, Salve Regina University, Newport, RI. July 4-9, 1999.
  • Dept. of Biology, M.I.T., Cambridge, MA. May 9, 1999.
  • Dept. of Molecular Biology, Vanderbilt University, Nashville, TN. May 6, 1999.
  • International Summer School, Nucleic Acid Chemistry, University of Copenhagen, Denmark. June 4 — 9, 1999.
  • Merck Basic Research Center (IRBM P. Angeletti), Rome, Italy. March 22, 1999.
  • Dept. of Biochemistry, Center for Toxicology, Vanderbilt University School of Medicine, Nashville, TN. February 24, 1999.

  • International Carbohydrate Symposium, University of California San Diego, CA. August 10, 1998.
  • Dept. of Biology, Northern Illinois University, DeKalb, IL. March 27, 1998.

  • Second NIH Symposium on Therapeutic Oligonucleotides: Targeting Transcription Factors and Signaling Pathways, Washington, D.C. December 5, 1997.
  • 55th Pittsburgh Diffraction Conference, Athens, GA. November 6 - 8, 1997.
  • Dept. of Chemistry, Georgia State University, Atlanta, GA. November 5, 1997.
  • 38th International Symposium on: Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues, University of Indiana Medical School, Indianapolis. September 29 - 30, 1997.
  • 4th Cambridge Symposium on: Oligonucleotide Chemistry & Biology, Queens' College, Cambridge, U.K. August 31 - September 3, 1997.
  • Laboratory for Medicinal Chemistry, National Institutes of Health, National Cancer Center, Bethesda, MD. March 17, 1997.

  • Depts. of Biochemistry & Molecular Biology and Chemistry, The University of Chicago, Chicago, IL,. December 12, 1996.
  • Vienna Biocenter, University of Vienna, Vienna, Austria. October 31, 1996.
  • Dept. of Chemistry, Tufts University, Medford, MA. October 22, 1996.
  • Hoffmann-La Roche Symposium: Novel Synthetic Methods 1996, Gersau, Lake Lucerne, Switzerland. September 15 - 18, 1996.
  • Intl. Union of Crystallography XVII and American Crystallographic Association (ACA) Congress and General Assembly, Seattle, WA. August 8 - 17, 1996.
  • First Annual Meeting of the RNA Society, University of Madison, WI. May 29, 1996.
  • Colloquium RNA Biochemistry, Assembly of the study section members and supported researchers within the DFG (German Natl. Science Foundation), Bamberg, Germany. May 20, 1996.
  • Boston Area RNA Meeting, M.I.T. April 1, 1996.

  • Central Research Laboratories, CIBA Ltd., Basel, Switzerland. September, 1995.
  • Colloquium RNA Biochemistry, Assembly of the study section members and supported researchers within the DFG (German Natl. Science Foundation), Bayreuth, Germany. April 4, 1995.
  • Ribozyme Pharmaceuticals Inc. (RPI), Boulder, CO. March 24, 1995.
  • Dept. of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, IL. March 20, 1995.
Society Memberships
  • American Association for the Advancement of Science (AAAS)
  • American Biophysical Society
  • American Chemical Society (ACS)
  • American Crystallographic Association (ACA)
  • Intl. Society for the Study of the Origin of Life (ISSOL)
  • Intl. Society for Nucleosides, Nucleotides and Nucleic Acids (IS3NA)
  • New Swiss Chemical Society (NSCG)
  • Sigma Psi Society (M.I.T. Chapter)
  • Swiss Crystallographic Society (SKG)

Martin Egli