135. C. H. Johnson*, M. Egli and P. L. Stewart (2008) Structural Insights into a Circadian Oscillator. Science (Wash. DC), in press.

134. M. Egli* and P. L. Stewart (2008) Structural Aspects of the Cyanobacterial KaiABC Circadian Clock. In: Bacterial Circadian Clocks and Rhythms (J. L. Ditty, S. R. Mackey and C. H. Johnson, Eds.), Springer Publishers Inc., Heidelberg, Germany, in press. Download this chapter...

133. P. S. Pallan, C. Kreutz, S. Bosio, R. Micura and M. Egli* (2008) Effects of N2,N2-Dimethylguanosine on RNA Structure and Stability: Crystal Structure of an RNA Duplex with Tandem m22G:A Pairs. RNA 14, in press.

132. P. S. Pallan and M. Egli* (2008) Insights into RNA/DNA Hybrid Recognition and Processing by RNase H from the Crystal Structure of a Non-specific Enzyme-dsDNA Complex. Cell Cycle 7, 2562-2569. Download this article....

131. Y. Wang, S. Musser, S. Saleh, L. J. Marnett, M. Egli and M. P. Stone* (2008) Insertion of dNTPs Opposite the 1,N2-Propanodeoxyguanosine Adduct by the Sulfolobus solfataricus P2 DNA Polymerase IV. Biochemistry 47, 7322-7334. Download this article...

130. R. Pattanayek, D. R. Williams, S. Pattanayek, T. Mori, C. H. Johnson, P. L. Stewart and M. Egli* (2008) Structural Model of the Circadian Clock KaiB-KaiC Complex and Mechanism for Modulation of KaiC Phosphorylation. EMBO J. 27, 1767-1778. Download this article...

129. F. Wang, F. Li, M. Ganguly, L. A. Marky, B. Gold, M. Egli and M. P. Stone* (2008) A Bridging Water Anchors the Tethered 5-(3-aminopropyl)-2-Deoxyuridine Amine in the DNA Major Groove Proximate to the N+2 C:G Base Pair: Implications for Formation of Interstrand 5'-GNC-3' Cross-links by Nitrogen Mustards. Biochemistry 47, 7147-7157. Download this article...

128. P. S. Pallan, D. Ittig, A. Heroux, Z. Wawrzak, C. J. Leumann, and M. Egli* (2008) Crystal Structure of Tricyclo-DNA: An Unusual Compensatory Change of Two Adjacent Backbone Torsion Angles. Chem. Comm., 883-885. Download this article...

127. Adriana Irimia, Robert L. Eoff, Pradeep S. Pallan, F. Peter Guengerich, and M. Egli* (2007) Structure and Activity of Y-class DNA Polymerase Dpo4 from Sulfolobus solfataricus with Templates Containing the Hydrophobic Thymine Analog 2,4-Difluorotoluene. J. Biol. Chem., 282, 36421-36433. Download this article...

126. F. Li, P. S. Pallan, M. A. Maier, K. G. Rajeev, S. L. Mathieu, C. Kreutz, Y. Fan, J. Sanghvi, R. Micura, E. Rozners, M. Manoharan and M. Egli* (2007) Crystal Structure, Stability and in vitro RNAi Activity of Oligoribonucleotides Containing the Ribo-difluorotoluyl Nucleotide: Insights into Substrate Requirements by the Human RISC Ago2 Enzyme. Nucleic Acids Res., 35, 6424-6438. Download this article...

125. P. S. Pallan, P. Lubini, M. Bolli and M. Egli* (2007) Backbone-Base Inclination as a Fundamental Determinant of Nucleic Acid Self- and Cross-Pairing. Nucleic Acids Res., 35, 6611-6624. Download this article...

124. R. L. Eoff, A. Irimia, K. C. Angel, M. Egli and F. P. Guengerich* (2007) Hydrogen Bonding of 7,8-Dihydro-8-oxodeoxyguanosine with a Charged Residue in the Little Finger Domain Determines Miscoding Events in Sulfolobus solfataricus DNA Polymerase Dpo4. J. Biol. Chem., 282, 19831-19843. Download this article...

123. R. L. Eoff, K. C. Angel, M. Egli, and F. P. Guengerich* (2007). Molecular Basis of Selectivity of Nucleoside Triphosphate Incorporation Opposite O6-Benzylguanine by Sulfolobus solfataricus DNA Polymerase Dpo4: Steady-state and pre-steady-state kinetics and x-ray crystallography of correct and incorrect pairing. J. Biol. Chem., 282, 13573-13584. Download this article...

122. P. S. Pallan and M. Egli* (2007) Selenium modification of nucleic acids. Preparation of oligonucleotides with incorporated 2'-SeMe-uridine for crystallographic phasing of nucleic acid structures. Nature Protocols, 2, 647-651. Download this article...

121. P. S. Pallan and M. Egli* (2007) Selenium modification of nucleic acids. Preparation of phosphoroselenoate derivatives for crystallographic phasing of nucleic acid structures. Nature Protocols, 2, 640-646. Download this article...

120. M. Egli* and P. S. Pallan (2007) Insights from Crystallographic Studies into the Structural and Pairing Properties of Nucleic Acid Analogs and Chemically Modified DNA and RNA Oligonucleotides. Annu. Rev. Biophys. Biomol. Struct., 36, 281-305. Download this article...

119. M. Egli*, R. Pattanayek and S. Pattanayek (2007) Protein-Protein Interactions in the Cyanobacterial KaiABC Circadian Clock. In: Models, Mysteries and Magic of Molecules; Proceedings of the INDABA-5 Conference, Kruger National Park, South Africa, August 20-25, 2006, J. C. A. Boeyens, J. F. Ogilvie, Eds., Springer Publishers, Dordrecht, The Netherlands, 283-299. Download this chapter...

118. T. Mori, D. R. Williams, M. Byrne, X. Qin, M. Egli, H. Mchaourab, P. L. Stewart, C. H. Johnson* (2007) Elucidating the Ticking of an In Vitro Circadian Clockwork. PLOS Biol., 5, No. 4, e93 doi:10.1371/journal.pbio.0050093. Download this article...

117. P. S. Pallan, P. Lubini and M. Egli* (2007) A Left-Handed Supramolecular Assembly Around a Right-Handed Screw Axis in the Crystal Structure of Homo-DNA. Chem. Commun., 1447-1449. Download this article...

116. M. Egli* and S. Sarkhel (2007) Lone Pair-Aromatic Interactions: to Stabilize or Not to Stabilize. Acc. Chem. Res., 40, 197-205. Download this article...

115. Z. Luka, S. Pakhomova, L. V. Loukachevitch, M. Egli, M. E. Newcomer and C. Wagner* (2007) Five-methyltetrahydrofolate is Bound in Intersubunits Areas of Rat Liver Folate Binding Protein, Glycine N-methyltransferase. J. Biol. Chem., 4069-4075. Download this article...

114. L. V. Loukachevitch and M. Egli* (2007) Crystallization and Preliminary X-ray Analysis of Escherichia coli RNase HI-dsRNA Complexes. Acta. Cryst. Sect. F 63, 84-88. Download this article...

113. R. L. Eoff, A. Irimia, M. Egli and F. P. Guengerich* (2007) Sulfolobus solftataricus DNA polymerase Dpo4 is inhibited by wobble pairing between O6-methylguanine and cytosine but accurate bypass is preferred. J. Biol. Chem. 282, 1456-1467. Download this article...

112. M. Egli*, P. Lubini and P. S. Pallan (2007) The Long and Winding Road to the Structure of Homo-DNA. Chem. Soc. Rev 36, 31-45. Download this article...

111. M. Egli*, P. S. Pallan, R. Pattanayek, C. J. Wilds, P. Lubini, G. Minasov, M. Dobler, C. J. Leumann and A. Eschenmoser (2006) Crystal Structure of Homo-DNA and Nature's Choice of Pentose over Hexose in the Genetic System. J. Am. Chem. Soc. 128(33), 10847-10856. Download this article...

110. P. S. Pallan, P. von Matt, C. J. Wilds, K.-H. Altmann and M. Egli* (2006) RNA-Binding Affinities and Crystal Structure of Oligonucleotides containing Five-Atom Amide-Based Backbone Structures. Biochemistry 45, 8048-8057. Download this article...

109. M. Egli*(2006) DNA and RNA Structure. Chapter 2 in: Nucleic Acids in Chemistry and Biology (G. M. Blackburn, M. J. Gait, J. A. Grasby, D. Loakes & D. M. Williams, Eds.), Royal Society of Chemistry, Cambridge, UK, pp. 13-75. Download the chapter or Download chapter figures...

108. R. Pattanayek, D. R. Williams, S. Pattanayek, Y. Xu, T. Mori, C. H. Johnson, P. L. Stewart and M. Egli* (2006) Analysis of KaiA-KaiC Protein Interactions in the Cyanobacterial Circadian Clock Using Hybrid Structural Methods EMBO J. 25, 2017-2028. Download this article...

107. J. Xia, A. Noronha, I. Toudjarska, F. Li, A. Akinc, R. Braich, K. G. Rajeev, M. Egli and M. Manoharan (2006) siRNAs with a Ribo-difluorotoluyl Nucleotide: Structure, RISC-mediated Recognition, and Silencing. ACS Chem. Biol. 1, 176-183. Download this article...

106. A. Irimia, H. Zang, L. V. Loukachevitch, F. P. Guengerich and M. Egli* (2006) Calcium is a Cofactor of Polymerization but Inhibits Pyrophosphorolysis by the Sulfolobus solfataricus DNA Polymerase Dpo4. Biochemistry 45, 5949-5956. Download this article...

105. F. Li, S. Sarkhel, C. J. Wilds, Z. Wawrzak, T. P. Prakash, M. Manoharan and M. Egli* (2006) 2'-Fluoroarabino- and Arabinonucleic Acid Show Different Conformations, Resulting in Deviating RNA Affinities and Processing of Their Heteroduplexes with RNA by RNase H. Biochemistry 45, 4141-4152. Download this article...

104. H. Zang, A. Irimia, J.-Y. Choi, K. C. Angel, L. V. Loukachevitch, M. Egli and F. P. Guengerich (2006) Efficient and High Fidelity Incorporation of dCTP Opposite 7,8-Dihydro-8-oxodeoxyguanosine by Sulfolobus solfataricus DNA Polymerase Dpo4. J. Biol. Chem. 281, 2358-2372. Download this article...

103. B. Diop-Frimpong, T. P. Prakash, K. G. Rajeev, M. Manoharan and M. Egli* (2005) Crystal Structure of a DNA Duplex with 2'-O-[2-methoxy)ethyl]-2-thiothymidines: Stabilizing Contributions of the Sulfur-Modified Nucleotides. Nucleic Acids Res. 33, 5297-5307. Download this article...

102. P. S. Pallan, W. S. Marshall, J. Harp, F. C. Jewett III, Z. Wawrzak, B. A. Brown II, A. Rich, and M. Egli* (2005) Crystal Structure of a Luteoviral RNA Pseudoknot and Model for a Minimal Frameshifting Motif. Biochemistry, Accel. Publ., 44, 11315-11322. Download this article...

101. P. Haeberli, I. Berger, P. S. Pallan, and M. Egli* (2005) Syntheses of 4'-thioribonucleosides and thermodynamic stability and crystal structure of RNA oligomers with incorporated 4'-thiocytosine. Nucleic Acids Res. 33, 3965-3975. Download this article...

100. H. Zang, A. K. Goodenough, J.-Y. Choi, A. Irimia, L. V. Loukachevitch, I. D. Kozekov, K. C. Angel, C. J. Rizzo, M. Egli*, and F. Peter Guengerich* (2005) DNA Adduct Bypass Polymerization by Sulfolobus solfataricus DNA Polymerase Dpo4. Analysis and Crystal Structures of Multiple Base-Pair Substitution and Frameshift Products with the Adduct 1,N2-Ethenoguanine. J. Biol. Chem. 280, 29750-29764. Download this article...

99. M. Egli*, G. Minasov, V. Tereshko, P. S. Pallan, M. Teplova, G. B. Inamati, E. A. Lesnik, S. R. Owens, B. S. Ross, T. P. Prakash and M. Manoharan* (2005) Comprehensive Analysis of the RNA Affinity, Nuclease Resistance and Crystal Structure of Ten 2'-O-Ribonucleic Acid Modifications. Biochemistry 44, 9045-9057. Download this article...

98. R. Pattanayek, L. Sethaphong, C. Pan, M. Prhavc, T. P. Prakash, M. Manoharan, and M. Egli* (2004) Structural Rationalization of a Large Difference in RNA Affinity Despite a Small Difference in Chemistry Between Two 2'-O-Modified Nucleic Acid Analogs. J. Am. Chem. Soc., Vol. 126 Issue 46, Nov., 15006-7. Download this article...

97. M. Egli* and V. Tereshko (2004) Lattice- and Sequence-Dependent Binding of Mg2+ in the Crystal Structure of a B-DNA Dodecamer. In: Curvature and Deformation of Nucleic Acids: Recent Advances, New Paradigms (N. Stellwagen & U. Mohanty, Eds), ACS Symposium Series, Vol. 884, 87-109. Download this article...

96. M. Egli* (2004) Nucleic Acid Crystallography. Current Progress. Curr. Opin. Chem. Biol, Vol. 8 Issue 6, Dec., 580-91. Download this article...

95. X. Yu, T. Mori, R. Pattanayek, S. Pattanayek, M. Egli* and C. H. Johnson* (2004) Identification of Key Phosphorylation Sites in the Circadian Clock Protein KaiC by Crystallographic and Mutagenetic Analyses. Proc. Natl. Acad. Sci. U.S.A. 101, 13933-8. Download this article...

94. M. Egli (2004) "Deoxyribo Nanonucleic Acid": Antiparallel, Parallel and Unparalleled. Chem. & Biol. 11, 1027-1035. Download this article...

93. R. Pattanayek, J. Wang, T. Mori, X. Yu, C. H. Johnson* and M. Egli* (2004) Visualizing a Circadian Clock Protein: Crystal Structure of KaiC and Functional Insights. Molecular Cell 15, 375-388. Download this article...

92. C. H. Johnson* and M. Egli* (2004) Visualizing a Biological Clockwork's Cogs. Nature Struct. Molec. Biol. 11, 584-585. Download this article...

91. T. P. Prakash, A. Püeschl, E. Lesnik, V. Tereshko and M. Egli* and M. Manoharan* (2004) 2'-O-[2-(Guanidinium)ethyl]-5-methyluridine Modified Oligonucleotides: Synthesis and Stabilizing Effect on Duplex and Triplex Nucleic Acid Structures. Organic Lett. 6, 1971-1974. Download this article...

90. P. S. Pallan, C. J. Wilds, Z. Wawrzak, R. Krishnamurthy, A. Eschenmoser and M. Egli* (2003) Why Does TNA Pair More Strongly with RNA than with DNA? - An Answer from X-ray Analysis. Angew. Chem. Int. Ed. 115, 5893-5895. Download this article...

89. A. V. Velentza, M. S. Wainwright, M. Zasadzki, S. Mirzoeva, J. Haiech, P. J. Focia, M. Egli and D. M. Watterson* (2003) An Aminopyridazine Inhibitor of Death Associated Protein Kinase Attenuates Hypoxia-Ischemia Induced Brain Damage. Bioorg. Med. Chem. Lett. 13, 3465-3470. Download this article...

88. M. Egli*, V. Tereshko, G. N. Murshudov, R. Sanishvili, X. Liu and F. D. Lewis (2003) Face-to-face and Edge-to-face Pi-Pi Interactions in a Synthetic DNA with a Stilbenediether Linker. J. Am. Chem. Soc. 125, 10842-10849. Download this article...

87. S. Sarkhel, A. Rich and M. Egli* (2003) Water-Nucleobase "Stacking": H-Pi and Lone Pair-Pi Interactions in the Atomic Resolution Crystal Structure of an RNA Pseudoknot. J. Am. Chem. Soc. 125, 8998-8999. Download this article...

86. M. Egli*, S. Sarkhel, G. Minasov and A. Rich* (2003) Structure and Function of the Ribosomal Frameshifting Pseudoknot RNA from Beet Western Yellow Virus. Helv. Chim. Acta ("Festschrift Jack D. Dunitz") 86, 1709-1727. Download this article...

85. C. J. Wilds, M. A. Maier, M. Manoharan* and M. Egli* (2003) Structural Basis for Recognition of Guanosine by a Synthetic Tricyclic Cytosine Analogue: Guanidinium G-Clamp. Helv. Chim. Acta ("Festschrift Jack D. Dunitz") 86, 966-978. Download this article...

84. M. Prhavc, T. P. Prakash, G. Minasov, M. Egli* and M. Manoharan* (2003) 2'-O-{2-[2-(N,N-Dimethylamino)ethoxy]ethyl} Modified Antisense Oligonucleotides: Symbiosis of Charge Interaction Factors and Stereoelectronic Effects. Organic Lett. 5, 2017-2020. Download this article...

83. C. J. Wilds, R. Pattanayek, C. Pan, Z. Wawrzak and M. Egli* (2002) Selenium-Assisted Nucleic Acid Crystallography: Use of DNA Phosphoroselenoates for MAD Phasing. J. Am. Chem. Soc. 124, 14910-14916. Download this article...

82. T. P. Prakash, M. Manoharan*, A. S. Fraser, A. M. Kawasaki, E. Lesnik, N. Sioufi, J. M. Leeds, M. Teplova, and M. Egli (2002) 2'-O-[2-(Methylthio)ethyl]-Modified Oligonucleotide: An Analog of 2'-O-[2-(Methoxy)ethyl]-Modified Oligonucleotide with Improved Protein Binding Properties and High Binding Affinity to Target RNA. Biochemistry 41, 11642-11648. Download this article...

81. C. J. Wilds, Z. Wawrzak, R. Krishnamurthy, A. Eschenmoser and M. Egli* (2002) Crystal Structure of a B-form DNA Duplex Containing (L)-alpha-Threofuranosyl (3'-2') Nucleosides (TNA): A Simple Four Carbon Sugar is Easily Accommodated into the Backbone of DNA. J. Am. Chem. Soc. 124, 13716-13721. Download this article...

80. M. Teplova, C. J. Wilds, Z. Wawrzak, V. Tereshko, Q. Du, N. Carrasco, Z. Huang and M. Egli* (2002) Covalent Incorporation of Selenium Into Oligonucleotides for X-ray Crystal Structure Determination via MAD: Proof of Principle. Biochimie 84, 849-858. Download this article...

79. M. Egli* (2002) DNA-Cation Interactions: Quo Vadis? Chemistry& Biology 9, 277-286. Download this article...

78. M. Egli*, G. Minasov, L. Su and A. Rich* (2002) Metal Ion Coordination and Conformational Flexibility in a Viral RNA Pseudoknot at Atomic Resolution. Proc. Natl. Acad. Sci. U.S.A. 99, 4302-4307. Download this article...

77. Q. Du, N. Carasco, M. Teplova, C. J. Wilds, X. Kong, M. Egli and Z. Huang* (2002) Internal Derivatization of Oligonucleotides with Selenium for X-ray Crystallography Using MAD. J. Am. Chem. Soc. Comm. Ed. 124, 24-25. Download this article...

76. C. J. Wilds, M. A. Maier, V. Tereshko, M. Manoharan* and M. Egli* (2002) Direct Observation of a Cytosine Analogue that Forms Five Hydrogen Bonds to Guanosine: Guanyl G-Clamp. Angew. Chem. Int. Ed. 114, 123-125. Download this article...

75. V. Tereshko, M. Teplova, J. Brunzelle, D. M. Watterson and M. Egli* (2001) Crystal Structures of the Catalytic Domain of Human Protein Kinase Associated with Apoptosis and Tumor Suppression. Nature Struct. Biol. 8, 899-907. Download this article...

74. A. V. Velentza, A. M. Schumacher, C. Weiss, M. Egli and D. M. Watterson* (2001) A Protein Kinase Associated with Apoptosis and Tumor Suppression: Structure, Activity and Discovery of Peptide Substrates. J. Biol. Chem. 276, 38956-38965. Download this article...

73. C. J. Wilds, G. Minasov, P. von Matt, K.-H. Altmann and M. Egli* (2001) Studies of a Chemically Modified Oligodeoxynucleotide Containing a 5-Atom Amide Backbone Which Exhibits Improved Binding to RNA. Nucleosides, Nucleotides & Nucleic Acids. 20, 991-994.

72. M. Egli*, G. Minasov, M. Teplova, R. Kumar and J. Wengel (2001) X-ray Crystal Structure of a Locked Nucleic Acid (LNA) Duplex Composed of a Palindromic 10-mer DNA Strand Containing One LNA Thymine Monomer. Chem. Comm., 651-652. Download this article...

71. V. Tereshko, S. T. Wallace, N. Usman, F. Wincott and M. Egli* (2001) X-ray Crystallographic Observation of "In-line" and "Adjacent" Conformations in a Bulged Self-Cleaving RNA/DNA Hybrid. RNA 7, 405-420. Download this article...

70. V. Tereshko, C. J. Wilds, G. Minasov, T. P. Prakash, M. A. Maier, A. Howard, Z. Wawrzak, M. Manoharan and M. Egli* (2001) Detection of Alkali Metal Ions in DNA Crystals Using State-of-the-Art X-ray Diffraction Experiments. Nucleic Acids Res. 29, 1208-1215. Download this article...

69. M. Teplova, V. Tereshko, R Sanishvili, A. Joachimiak, T. Bushueva, W. F. Anderson and M. Egli* (2000) The Structure of the yrdC Gene Product From E. coli Reveals a New Fold and Suggests a Role in RNA-Binding. Protein Sci. 9, 2557-2566. Download this article...

68. G. Minasov, J. Matulic-Adamic, C. J. Wilds, P. Haeberli, N. Usman, L. Beigelman and M. Egli* (2000) Crystal Structure of an RNA Duplex Containing Phenyl-ribonucleotides, Hydrophobic Isosteres of the Natural Pyrimidines. RNA 6, 1516-1528.

67. M. Egli* and S. M. Gryaznov* (2000) Synthetic Oligonucleotides as RNA Mimetics: 2’-Modified RNAs and N3’® P5’ Phosphoramidates. Cell. Mol. Life Sci. 57, 1440-1456. Download this article...

66. M. Egli* and G. Minasov (2000) Recent Advances in RNA Crystallography. In "Ribozymes, Biochemistry and Biotechnology" (Krupp, G. & Gaur, R., Eds.), Eaton Publishing, Natick, MA, pp. 315-349.

65. N. Mashhoon, A. J. DeMaggio, V. Tereshko, S. C. Bergmeier, M. Egli, M. F. Hoekstra and J. Kuret* (2000) Crystal Structure of a Conformation-Selective Casein Kinase-1 Inhibitor. J. Biol. Chem. 275, 20052-20060. Download this article...

64. G. Minasov, M. Teplova, G. C. Stewart, E. V. Koonin, W. F. Anderson and M. Egli* (2000) Functional Implications From Crystal Structures of the Conserved Bacillus subtilis Maf Protein With and Without dUTP. Proc. Natl. Acad. Sci. U.S.A. 97, 6328-6333. Download this article...

63. G. Minasov, M. Teplova, P. Nielsen, J. Wengel and M. Egli* (2000) Structural Basis of Cleavage by RNase H of Hybrids of Arabinonucleic Acids and RNA. Biochemistry 39, 3525-3532. Download this article...

62. M. Egli*, V. Tereshko, M. Teplova, G. Minasov, A. Joachimiak, R. Sanishvili, C. M. Weeks, R. Miller, M. A. Maier, H. An, P. D. Cook and M. Manoharan (2000) X-ray Crystallographic Analysis of the Hydration of A- and B-Form DNA at Atomic Resolution. Biopolymers (Nucleic Acid Sciences) 48, 234-252. Download this article...

61. M. Teplova, S. T. Wallace, G. Minasov, V. Tereshko, A. Symons, P. D. Cook, M. Manoharan* and M. Egli* (1999) Structural Origins of the Exonuclease Resistance of a Zwitterionic RNA. Proc. Natl. Acad. Sci. U.S.A. 96, 14240-14245. Download this article...

60. F. D. Lewis*, X. Liu, Y. Wu, S. Miller, M. R. Wasielewski, R. L. Letsinger, R. Sanishvili, A. Joachimiak, V. Tereshko and M. Egli (1999) Structure and Photoinduced Electron Transfer in Exceptionally Stable Synthetic DNA Hairpins with Stilbenediether Linkers. J. Am. Chem. Soc. 121, 9905-9906. Download this article...

59. I. Berger, M. Egli, N. Spackova, J. Sponer and A. Rich* (1999) Four-Stranded Intercalated Cytosine-Rich Molecules: Novel Insights into DNA Structure and Stability. Nucleosides & Nucleotides 18, 1583-1585.

58. G. Minasov, V. Tereshko and M. Egli* (1999) Atomic-Resolution Crystal Structures of B-DNA Reveal Specific Influences of Divalent Metal Ions on Conformation and Packing. J. Mol. Biol 291, 83-99. Download this article...

57. M. Teplova, G. Minasov, V. Tereshko, G. Inamati, P. D. Cook, M. Manoharan* and M. Egli* (1999) Crystal Structure and Improved Antisense Properties of 2’-O-(2-methoxyethyl)-RNA. Nature Struct. Biology 6, 535-539. Download this article...

56. V. Tereshko, G. Minasov and M. Egli* (1999) A "Hydrat-Ion" Spine in a B-DNA Minor Groove. J. Am. Chem. Soc. 121, 3590-3595. Download this article...

55. T. V. Maltseva , K.-H. Altmann, M. Egli and J. Chattopadhyaya* (1999) The Residence Time of the Bound Water in the Hydrophobic Minor Groove of the Carbocyclic-Nucleoside Analogs of Dickerson-Drew Dodecamers. J. Biomol. Struct. Dyn. 16, 569-578.

54. A. Y. Denisov, E. V. Zamaratski, T. V. Maltseva, A. Sandström, S. Bekiroglu, K.-H. Altmann, M. Egli and J. Chattopadhyaya* (1999) The Solution Conformation of a Carbocyclic Analog of the Dickerson-Drew Dodecamer: Comparison with its own X-ray Structure and that of the NMR Structure of the Native Counterpart. J. Biomol. Struct. Dyn. 16, 547-568.

53. L. Su, L. Chen, M. Egli, J. M. Berger and A. Rich* (1999) A Minor Groove RNA Triplex in the Crystal Structure of a Viral Pseudoknot Involved in Ribosomal Frameshifting. Nature Struct. Biology 6, 285-292. Download this Article...

52. V. Tereshko, G. Minasov and M. Egli* (1999) The Dickerson-Drew B-DNA Dodecamer Revisited - At Atomic Resolution. J. Am. Chem. Soc. 121, 470-471. Download this Article...

51. H. H. Engelhard*, M. Egli and J. M. Rozental (1998) Use of Antisense Vectors and Oligodeoxynucleotides in Neuro-Oncology. Pediatr. Neurosurg. 28, 279-285.

50. V. Tereshko, S. Portmann, E. Tay, P. Martin, F. Natt, K.-H. Altmann and M. Egli* (1998) Structure and Stability of DNA Duplexes with Incorporated 2’-O-Modified RNA Analogues. Biochemistry 37, 10626-10634.

49. N. Spackova, I. Berger, M. Egli and J. Sponer* (1998) Molecular Dynamics of Hemiprotonated Intercalated Four Stranded i-DNA: Stable Trajectories on a Nanosecond Scale. J. Am. Chem. Soc. 120, 6147-6151.

48. I. Berger, V. Tereshko, H. Ikeda, V. E. Marquez and M. Egli* (1998) Crystal Structures of B-DNA with Incorporated 2’-Deoxy-2’-fluoro-arabinofuranosyl Thymines: Implications of Conformational Preorganization for Duplex Stability. Nucleic Acids Res. 26, 2473-2480.

47. M. Egli* (1998) Conformational Preorganization and Thermodynamic Stability in Oligonucleotide Duplexes. Antisense & Nucleic Acid Drug Development 8, 123-128.

46. M. Egli* (1998) Towards the Structure-Based Design of Nucleic Acid Therapeutics. Advances in Enzyme Regulation. G. Weber (Ed.) Vol. 38, Elsevier Science Ltd., Oxford, UK, pp. 181-203.

45. V. Tereshko, S. Gryaznov and M. Egli* (1998) Consequences of Replacing the DNA 3’-Oxygen by an Amino Group: High-Resolution Crystal Structure of a Fully Modified N3’-->P5’ Phosphoramidate DNA Dodecamer Duplex. J. Am. Chem. Soc. 120, 269-283.

44. R. K. Allemann and M. Egli* (1997) DNA Bending and Recognition. Chem. & Biol. 4, 643-650.

43. I. Berger and M. Egli* (1997) The Role of Backbone Oxygen Atoms in the Organization of Nucleic Acid Tertiary Structure: Zippers, Networks, Clamps and C-H...O Hydrogen Bonds. Chem. Europ. J. 3, 1400-1404.

42. M. Egli* (1997) In Vitro Selected Receptors Rationalized: The First 3D-Structures of RNA Aptamer/Substrate Complexes. Angew. Chem. Int. Ed. Engl. 36, 480-482.

41. S. Portmann, K.-H. Altmann, N. Reynes and M. Egli* (1997) Crystal Structures of Oligodeoxyribonucleotides Containing 6'-a-Methyl and 6'-a-Hydroxy Carbocyclic Thymidines. J. Am. Chem. Soc. 119, 2396-2403.

40. I. Berger, M. Egli and A. Rich* (1996) Inter-strand C-H...O Hydrogen Bonds Stabilizing Four-Stranded Intercalated Molecules: Stereoelectronic Effects of O4' in Cytosine-Rich DNA. Proc. Natl. Acad. Sci. U.S.A. 93, 12116-12121.

39. M. Egli* (1996) Structural Aspects of Nucleic Acid Analogs and Antisense Oligonucleotides. Angew. Chem. Int. Ed. Engl. 35, 1894-1909.

38. M. Egli*, S. Portmann and N. Usman (1996) RNA Hydration: A Detailed Look. Biochemistry 35, 8489-8494.

37. J. Matulic-Adamic, L. Beigelman, S. Portmann, M. Egli and N. Usman* (1996) Synthesis and Structure of 1-Deoxy-1-Phenyl-b-D-Ribofuranose and Its Incorporation Into Oligonucleotides. J. Org. Chem. 61, 3909-3911.

36. S. Portmann, S. Grimm, C. Workman, N. Usman and M. Egli* (1996) Crystal Structures of an A-Form Duplex Containing Single-Base Bulges and a Conformational Basis for Site-Specific RNA Self-Cleavage. Chemistry & Biology 3, 173-184.

35. M. Egli*, S. Portmann, D. Tracz, C. Workman and N. Usman (1995) Crystallization and Preliminary X-Ray Diffraction Analysis of Double-Helical RNA Octamers. Acta Cryst. D 51, 1065-1070.

34. B. Hyrup, C. Richert, T. Schulte-Herbrüggen, S. A. Benner and M. Egli* (1995) X-Ray Crystal Structure of a Dimethylene Sulfone-Bridged Ribonucleotide Dimer in a Single-Stranded State. Nucleic Acids Res. 23, 2427-2433.

33. A. L. Roughton, S. Portmann, S. A. Benner and M. Egli* (1995) Crystal Structure of a Dimethylene Sulfone Linked Ribodinucleotide Analog. J. Am. Chem. Soc. 117, 7249-7250.

32. S. Zhang and M. Egli* (1995) A Proposed Complementary Pairing Mode Between Single-Stranded Nucleic Acids and b-Stranded Peptides: A Possible Pathway for Generating Complex Biological Molecules. Complexity 1, 49-56.

31. S. Portmann, N. Usman and M. Egli* (1995) The Crystal Structure of r(CCCCGGGG) in Two Distinct Lattices. Biochemistry 34, 7569-7575.

30. M. Egli* and R. V. Gessner (1995) Stereoelectronic Effects of Deoxyribose O4' on DNA Conformation. Proc. Natl. Acad. Sci. U.S.A. 92, 180-185.

29. S. Zhang and M. Egli* (1994) A Hypothesis: Reciprocal Information Transfer Between Oligonucleotides and Oligopeptides in Prebiotic Molecular Evolution. Origins of Life 24, 495-505.

28. P. Lubini, W. Zürcher and M. Egli* (1994) Crystal Structure of an Oligodeoxynucleotide Duplex Containing 2'-O-methylated Adenosines. Chemistry & Biology 1, 39-45.

27. R. V. Gessner, G. J. Quigley and M. Egli* (1994) Comparative Studies of High Resolution Z-DNA Crystal Structures. Part 1: Common Hydration Patterns of Alternating dC-dG. J. Mol. Biol. 236, 1154-1168.

26. P. Lubini and M. Egli* (1994) A Parallel-Stranded Double Helix at Atomic Resolution. In: Structural Biology: State of the Art 1993: Proceedings of the Eighth Conversations. R. H. Sarma, M. H. Sarma, (Eds) Adenine Press, Albany, NY, Vol. 2, pp. 155-176.

25. D. Bancroft, L. D. Williams, A. Rich and M. Egli* (1994) The Low Temperature Crystal Structure of the Pure-Spermine Form of Z-DNA Reveals Binding of a Spermine Molecule in the Minor Groove. Biochemistry 33, 1073-1086.

24. M. Egli* (1994) Structural Patterns in Nucleic Acids. pp. 705-749. In: Structure Correlations. J. D. Dunitz and H. B. Bürgi (Eds.) VCH-Publishers, Weinheim.

23. M.Egli*, P. Lubini, M. Bolli, M. Dobler and Ch. Leumann (1993) Crystal Structure of a Parallel-Stranded Duplex of a Deoxycytidylyl-(3'-5')-deoxycytidine Analogue Containing Intranucleosidyl C(3')-C(5') Ethylene Bridges. J. Am. Chem. Soc. 115, 5855-5856.

22. M. Egli*, N. Usman and A. Rich (1993) Conformational Influence of the Ribose 2'-Hydroxyl Group: Crystal Structures of DNA-RNA Chimeric Duplexes. Biochemistry 32, 3221-3237.

21. N. Usman, M. Egli and A. Rich* (1992) Large Scale Chemical Synthesis, Purification and Crystallization of RNA-DNA Chimeras. Nucleic Acids Res. 20, 6695-6699.

20. D. Seebach*, B. Lamatsch, R. Amstutz, A. K. Beck, M. Dobler, M. Egli, R. Fitzi, M. Gautschi, B. Herradon, et al. (1992) Structure and Reactivity of Five- and Six-ring N,N-, N,O-, and O,O-Acetals: A Lesson in A1,3 Strain. Helv. Chim. Acta 75, 913-934.

19. L. D. Williams, M. Egli, Q. Gao and A. Rich* (1992) DNA Intercalation: Helix Unwinding and Neighbor-Exclusion. In: Structure & Function: Proceedings of the Seventh Conversation in Biomolecular Stereodynamics, R. H. Sarma, M. H. Sarma (Eds) Adenine Press, Albany, NY, pp. 107-125.

18. M. Egli, N. Usman, S. Zhang and A. Rich* (1992) Crystal Structure of an Okazaki Fragment at 2 Ã… Resolution. Proc. Natl. Acad. Sci. U.S.A. 89, 534-538.

17. M. Egli*, L. D. Williams, Q. Gao and A. Rich* (1991) Structure of the Pure-Spermine Form of Z-DNA (Magnesium Free) at 1Å Resolution. Biochemistry 30, 11388-11402.

16. Q. Gao, L. D. Williams, M. Egli, D. Rabinovich, S.-L. Chen, G. J. Quigley and A. Rich* (1991) Drug induced DNA Repair: X-ray Structure of a DNA-Ditercalinium Complex. Proc. Natl. Acad. Sci. U.S.A. 88, 2422-2426.

15. M. Egli, L. D. Williams, C. A. Frederick and A. Rich* (1991) DNA-Nogalamycin Interactions. Biochemistry 30, 1364-1372.

14. L. D. Williams, M. Egli, G. Ughetto, G. A. van der Marel, J. H. van Boom, G. J. Quigley, A. H.-J. Wang, A. Rich* and C. A. Frederick* (1990) Structure of 11-Deoxydaunomycin Bound to DNA Containing a Phosphorothioate. J. Mol. Biol. 215, 313-320.

13. M. Egli, R. Gessner, L. D. Williams, G. J. Quigley, G. A. van der Marel, J. H. van Boom, A. Rich* and C. A. Frederick* (1990) Atomic-resolution Structure of the Cellulose Synthase Regulator Cyclic Diguanylic Acid. Proc. Natl. Acad. Sci. U.S.A. 87, 3235-3239.

12. L. D. Williams, M. Egli, Q. Gao, P. Bash, G. A. van der Marel, J. H. van Boom, A. Rich* and C. A. Frederick* (1990) Structure of Nogalamycin Bound to a DNA Hexamer. Proc. Natl. Acad. Sci. U.S.A. 87, 2225-2229.

11. D. Seebach*, U. Brändli, H.-M. Müller, M. Dobler, M. Egli, M. Przybylski and K. Schneider (1989) On the Macrolactonization of b-Hydroxyacids. Crystal Structures of the Pentolide and the Hexolide from (R)-3-Hydroxybutanoic Acid. Molecular Modeling Studies of the Tetrolide. Helv. Chim. Acta 72, 1704- 1717.

10. V. Prelog*, M. Kovacevic and M. Egli (1989) Lipophilic Tartaric Acid Esters as Enantioselective Ionophores. Angew. Chem. Int. Ed. Engl. 28, 1147-1152.

9. M. Egli and M. Dobler* (1989) Structural Aspects of the Enantioselectivity of Tartrates with a-Amino-alcohol Salts, Part II: Crystal Structures of (1R,2S)-Norephedrine Hydrochloride and (1R,2R)-Norpseudo-ephedrine Hydrochloride. Helv. Chim. Acta 72, 1151-1157.

8. M. Egli and M. Dobler* (1989) Structural Aspects of the Enantioselectivity of Tartrates with a-Amino-alcohol Salts, Part I: Crystal Structures of Eleven Tartaric Acid Diesters. Helv. Chim. Acta 72, 1136-1150.

7. M. Egli, R. Polt and D. Seebach* (1989) Diastereoselective Cyclisation of a Glycil-alanine Azomethine to a Imidazolidinone: Determination of the Product Configuration by X-Ray Analysis. Chimia 43, 4-5.

6. M. Eberle, M. Egli and D. Seebach* (1988) Enantioselective Saponification of Diacetates of 2-Nitro-1,3-propanediols by Pig Liver Esterase and Preparation of Enantiomerically Pure Derivatives of 2-Nitro-allylic Alcohols. Helv. Chim. Acta 71, 1-23.

5. K. Thiele, L. Zirngibel, M. H. Pfenninger, M. Egli and M. Dobler* (1987) Synthesis and X-Ray Analysis of Omoconazol. Helv. Chim. Acta 70, 441-444.

4. E. Metzger, R. Aeschimann, M. Egli, R. Dohner, D. Amman, M. Dobler and W. Simon* (1986) 3,7-Dioxaazelaamides as Ionophores for Lithium Ion Selective Liquid Membrane Electrodes. Helv. Chim. Acta 69, 1821-1828.

3. M. Egli and M. Dobler (1986) Crystal Structures of Chiral Ionophores. Helv. Chim. Acta 69, 626-631.

2. M. Egli, J. D. Wallis and J. D. Dunitz* (1986) Structure of N,N-Dimethyl-8-nitro-1-naphthaleneamine in Seven Crystalline Environments. Helv. Chim. Acta 69, 255-266.

1. M. Dobler, M. Dumic, M. Egli and V. Prelog* (1985) Chiral Poly((9,9’)-spirobifluorene) Crown Ethers. Angew. Chem. Int. Ed. Engl. 24, 792-794.