Structural Biology Symposium


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Program

All events will be held at Vanderbilt University, please see the travel page or campus map for further information. Registration for the symposium includes all events at Wilson Hall.

Friday, March 6

Wilson Hall room 126 and lobby
8:30-9 AM Registration and light breakfast

Session I (Chair: Sarah Warnick)
   9:00-9:10 Opening Remarks by John York - Vanderbilt University
   9:10-9:35 Chuck Sanders - Vanderbilt University
                        "Ride the magic bus"
   9:35-9:55 Steven Damo - Fisk University
                        "Calprotectin: more than just a calcium binding protein"
   9:55-10:15 Craig Vander Kooi - University of Kentucky
                        "Using the toolbox: structure and interactions of neuropilin"
   10:15-10:40 John Christodoulou - University College London
                        "Protein folding on the ribosome"

10:40-11:10 Coffee/tea break

Session II (Chair: Christopher Johnson)
   11:10-11:35 Anders Malmendel - University of Copenhagen
                        "Chazin' flies for NMR"
   11:35-11:55 Brian Weiner - Monsanto
                        "Practical protein design"
   11:55-12:15 Melanie Nelson - MRN consulting
                        "Structuring my life: lessons from graduate school"
   12:15-12:35 Johan Kordel - Lund University, Lundbeckfond Ventures
                        "What Walter taught me about investing in Life Science companies"

12:35-2:00 PM Lunch

Session III (Chair: Norie Sugitani)
   2:00-2:25 Michael Feldkamp - Vanderbilt University
                        "We have the technology, we can redesign it: a better, faster, stronger RPA70N for small molecule discovery"
   2:25-2:45 Sivaraja Vaithiyalingam - St. Jude Children's Research Hospital
                        "My journey with Walter to learn about DNA primase"
   2:45-3:05 Lena Maler - Stockholm University
                        "Membrane interactions of glycosyltransferases"
   3:05-3:25 Susan Meyn - Vanderbilt University
                        "My life with Walter: reflections of one lab manager"

3:25-3:55 Coffee/tea break

Session IV (Chair: Aaron Ehlinger)
   3:55-4:20 Jacek Kuznicki - International Institute of Molecular and Cell Biology
                        "From calcyclin through beta-catenin to bipolar disease"
   4:20-4:40 Mark Rance - University of Cincinnati
                        "Lysine side-chain dynamics in protein-DNA complexes"
   4:40-5:05 Nick Skelton - Genentech
                        "Life after paradise isn't so bad"

Reception and dinner at Student Life Center Ballroom A

Separate registration required

6:00 PM Reception sponsored by Cambridge Isotope Laboratories
7:30 PM Dinner
After dinner speach by Walter Chazin

Saturday, March 7th

Wilson Hall room 126 and lobby
8:45-9:10 AM Coffee and pastries

Session V (Chair: Kevin Weiss)
   9 AM Opening remarks
   9:10-9:35 Jonathan Moore - Vertex Pharmaceuticals
                        "Biophysical methods for lead generation and optimization in drug discovery"
   9:35-9:55 Giuseppe Bifulco - University of Salerno, Italy
                        "From organic chemistry to structural biology and back..."
   9:55-10:15 Jarrod Smith - Vanderbilt University
                        "Tagdock: a monte carlo approach to oligomeric protein model consruction and experiment planning"
   10:15-10:35 Arun Alphonse Ignatius - Pfizer
                        "Overview of biotherapeutics development"

10:35-10:45 Group picture 10:45-11:05 Coffee/tea and snack break

Session VI (Chair: Chris Brosey)
   11:05-11:30 Art Palmer - Columbia University Medical Center
                        "Conformational dynamics and activity in ribonuclease H enzyme using NMR spectroscopy and MD simulations"
   11:30-11:50 Antonio Randazzo - University of Naples Federico II
                        "DNA G-quadruplexes: a holistic view"
   11:50-12:10 Michael Hunter - Johnson and Johnson
                        "Walter and beyond (or CBCA(CO)NH what?)"
   12:10-12:30 Sudha Veeraraghavan - University of Maryland
                        "Flexing the structural muscles towards Hippo and more"

12:30-1:30 PM Lunch

Session VII (Chair: Steven Damo)
   1:30-1:55 David Millar - Scripps Research Institute
                        "Single-molecule view of GPCR activation"
   1:55-2:15 Chris Brosey - Washington University School of Medicine
                        "Do the twist: functional dynamics in replication protein A inter-domain diffusion"
   2:15-2:35 Georges Mer - Mayo Clinic
                        "Post-translational modifications in DNA damage response"
   2:35-2:55 Barbara Potts - Allergan Inc.
                        "Career Chameleon"

3-3:30 Coffee/tea break

Session VIII (Chair: Xiaohua Jiang)
   3:30-3:45 Yoana Dimitrova - Harvard Univeristy
                        "The inestimable utility of a calming influence, when science and life are falling to pieces"
   3:45-4:05 Vikas O'Reilly-Shah - Emory Univeristy
                        "Dr. Chazin, or: how I learned to stop worrying and love HSQC"
   4:05-4:35 Mikael Akke - Lund University
                        "Dynamics and thermodynamics of ligand binding (and life)"
   4:35-4:55 Closing remarks by Walter Chazin
                        "What lies ahead?"


* An informal gathering is planned for Saturday evening for those who are interested *


This symposium is supported by The Vanderbilt Department of Biochemistry, Department of Chemistry, Bruker Biospin, Thermo Fisher Life Technologies, Vertex Pharmaceuticals, ISOTEC, and Cambridge Isotope Laboratories.
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