The information presented here was taken from Nakayama,S., N. Moncrief,
and R. Kretsinger, (1992) J. Mol. Evol. 34, 416-448.
However, any inaccuracies are my own.
The following proteins were found to be congruent, meaning that their individual
domains branch together: calmodulin, troponin C, essential light chain of
myosin, regulatory light chain of myosin, call, squidulin, CDC31, caltractin,
and calcium-dependent protein kinase.
General Consequences of this Scheme
- The equivalent domains of two different proteins are more closely related
than the two domains of a given protein
- Within a single protein, EF1 is more closely related to EF3 than to EF2
or EF4 and EF2 is more closely related to EF4 than to EF1 or E3
Branch Points of Specific Protein
- All of calmodulin's hands branch from the corresponding EF domains
- All of troponin C's hands branch from the corresponding EF domains
- All of ELC's hands branch from the corresponding EF domains
- All of RLC's hands branch from the corresponding EF domains
- All of call's hands branch from the corresponding EF domains
- Squidulin hands 2,3, and 4 branch from EF domains. Domain 1 branches i
- CDC31 and caltractin are grouped into a single subfamily. Their hands
3 and 4 branch from the corresponding EF domains. Hand 1 branches from ODD, i
and hand 2 branches from even.
- The calmodulin-like domain of calcium-dependent protein kinase is
congruent with the other proteins listed here. Its hands all branch
from EF domains.
Because these proteins are congruent with each other, all four of their
EF hands can be used simultaneously to derive their evolutionary relationship,
as shown below:
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