Program
POSTER FLASH DETAILS
On the first night of the symposium, we will hold a special event called a "poster flash" session. At this session, each poster presenter will have 1 minute to present 1 simple slide, with the goal of attracting everyone to view your poster, meet you and discuss your work. Since many posters have been submitted, it is important that we run the session efficiently. Hence, it is imperative that you send your slide ahead of time so we have them all loaded on the computer and can keep the progress at a rapid fire pace.
Please send your slide to CaBP19@csb.vanderbilt.edu. Be sure to label the slide as posternumber_familyname so we can place them in order. Some people have mentioned issues sending emails to the CaBP19 email address, so slides may also be sent directly to Karen Davis at karen.d.davis@vanderbilt.edu.
Poster board assignment can be found here.
Scientific Program and Speakers:
Saturday, May 30 - 3:30pm - 5:30pm
Ebashi Lecture
David MacLennan, Ph.D.; University of Toronto; Toronto, Ontario, Canada
Sarcoplasmic Reticulum Calcium Binding Proteins in Health and Disease
Ernesto Carafoli, Session Chair
Sunday, May 31 - 9:00am - 4:30pm
Session 1 - Calmodulin - 9:00 am
Anthony Means, Session Chair
- John Putkey, Ph.D.; UT Health Medical School; Houston, Texas, USA
The Molecular Mechanism of Intrinsically Disordered Regulators of CaM Signaling - Madeline Shea, Ph.D.; University of Iowa; Iowas City, Iowa, USA
One CaM to Bind Them: Calmodulin Discriminates Among Nine Human Voltage-Gated Sodium Channels - Manu Ben Johny; Johns Hopkins University; Baltimore, Maryland, USA
Conservation of CaM Regulation Across Voltage-Gated Calcium and Sodium Channels - Christopher N. Johnson; Vanderbilt University; Nashville, Tennessee, USA
Ca2+ Regulation of the Human Cardiac Sodium Channel Nav1.5: Calmodulin Interacting with the Fast Inactivation Gate and Effects of Disease Associated Mutations - Yuequan Shen; Nankai University; Tianjin, China
Calcium Signaling Dynamically Control Chaperone System in Mitochondria to Regulate Leaf Senescence
Session 2 - Breakthrough Cryo EM structures of RyRs - 11:00 am
Poul Nissen and Wayne Chen, Session Co-Chairs
- Nieng Yan, Ph.D.; Tsinghua University; Beijing, China
Structural basis for the long range allosteric regulation and high ion conductance of the ryanodine receptor RyR1 - Oliver Clarke, Ph.D.; Columbia University; New York, New York, USA
Structural insights into ryanodine receptor gating - Rouslan Efremov, Ph.D.; VIB Structural Biology Research Center; Brussels, Belgium
Structure and dynamics of ryanodine receptor
Session 3 - Imaging/Detecting Ca signals - 2:30 pm
Katsuhiko Mikoshiba, Session Chair
- Jonathan Lederer, Ph.D.; University of Maryland; Baltimore, Maryland, USA
Mechano-chemo transduction: X-ros-dependent Ca2+ signaling in heart - Ian Parker, Ph.D.; University of California Irvine; Irvine, California, USA
Imaging and localizing IP3-evoked calcium signals and IP3 receptors at the single-channel level - Takeharu Nagai, Ph.D.; Osaka University; Osaka, Japan
Genetically-encoded tools to optically control and image calcium dynamics - Erica Shannon; Vanderbilt University; Nashville, Tennessee, USA
Calcium Dynamics as a Potential Readout of Mechanotransduction at Epithelial Wounds - Shigenori Inagaki; Osaka University; Osaka, Japan
Genetically-encoded Chemiluminescent Indicator Applicable in Milli-second Voltage Phenomena
Monday, June 1 - 9:00am - 4:30pm
Session 4 - Interesting CaBP structures: Ca2+-gated membrane proteins - 9:00 am
Joachim Krebs, Session Chair
- Youxing Jiang, Ph.D.; UT Southwestern; Dallas, Texas, USA
Structural study of a plant RCK-regulated nuclear membrane channel - Raimund Dutzler, Ph.D.; University of Zurich; Zurich, Switzerland
Structure and function of Ca2+ activated TMEM16 channels and scramblases - Stephen Long, Ph.D.; Memorial Sloan Kettering Cancer Center; New York, New York, USA
Structure and insights into the function of the bestrophin calcium-activated chloride channel - Alexander Dizhoor; Salus University; Elkins Park, Pennsylvania, USA
Targeting Photopreceptor Membrane Guanylyl Cyclase (RetGC) by Calcium-sensor Proteins: Role of Protein Domains and the Effects of Mutations Linked to Congenital Blindness - Anand Sharma; Centre for Cellular & Molecular Biology; Hyderabad, India
Identification of SCGN as a Cytosolic Insulin Binding Protein
Session 5 - Membrane associated CaBPs - 11:00 am
Volker Gerke, Session Chair
- Stephen Moss, Ph.D.; University College London; London, England
Integrated functions for annexins in the mammalian retina - James B. Ames, Ph.D.; University of California Davis; Davis, California, USA
Calmodulin Capping of PSD-95 Triggers its Postsynaptic Release - Edwin R. Chapman, Ph.D.; University of Wisconsin - Madison; Madison Wisconsin, USA
Engineering Ca2+-sensors for exocytosis - Katarzyna Zoltowska; Harvard Medical School/Massachusets General Hospital; Charlestown, Massachusetts, USA
Synaptotagmin 1 in Alzheimer's Disease - Guard or Partner in Crime? - Haifeng Zheng; University of Nevada Reno; Reno, Nevada, USA
Na+/Ca2+ Exchange Contributes to the Regulation of the Pacemaker Activity of Interstitial Cells
Session 6 - S100 proteins - 2:30 pm
David J. Weber, Session Chair
- David J. Weber, Ph.D.; University of Maryland; Baltimore, Maryland, USA
Structure, function, and inhibition of S100B in malignant melanoma - Mariam Grigorian, M.D., Ph.D.; University of Copenhagen; Copenhagen, Denmark
Metastasis-inducing S100A4 in the pro-inflammatory pathways of Non-Communicable Diseases - Julia Ritterhoff, Ph.D.; University of Heidelberg; Heidelberg, Germany
S100A1 in cardiovascular health and disease: From molecule to therapy - Ulrike Stein; Charite - Universitatsmedizin Berlin; Berlin, Germany
S100A4: Key Player in Cancer Metastasis and Signaling-based Interventions for Metastasis Restriction - Marie-Luce Bochaton-Piallat; University of Geneva; Geneva, Switzerland
S100A4 Promotes Smooth Muscle Cell Phenotypic Transition. Implications in Atherosclerosis
Tuesday, June 2 - 9:00am - 5:30pm
Session 7 - CaBP reengineering and design - 9:00 am
Robert Kretsinger, Session Chair
- Jenny Yang, Ph.D.; Georgia State University; Atlanta, Georgia, USA
Design calcium binding proteins for molecular imaging - Gary S. Shaw, Ph.D.; University of Western Ontario; London, Ontario, Canada
Come Together: Designing S100 Proteins to Identify New Biological Complexes - Yogendra Sharma, Ph.D.; Centre for Cellular & Molecular Biology; Hyderabad, India
Ca2+-binding beta gamma-crystallins: An affair that didn't last - Masayuki Nara; Tokyo Medical and Dental University; Tokyo, Japan
Infared Studies on the Ca2+-Bound Coordination Structure of Synthetic Peptide Analogues of the Ca2+-Binding Site - Belinda Pastrana-Rios; University of Puerto Rico; Rincon, Puerto Rico
Novel Centrin-PRP40 Complex: Its Molecular Biophysical Characterization and Crystal Screens
Session 8 - Store-operated calcium entry (SOCE): players and mechanisms - 11:00 am
Mitsu Ikura, Session Chair
- Patrick Hogan, Ph.D.; La Jolla Institute for Allergy & Immunology; La Jolla, California, USA
The mechanics of STIM-ORAI communication - Stefan Feske, Ph.D.; New York University; New York, New York, USA
STIM1-mediated Ca2+ influx controls immune regulation and inflammation in chronic infection - Natalia Prevarskaya, Ph.D; Lille University of Science and Technology; Lille, France
Calcium and calcium channels in initiation and progression of prostate cancer - Alexey Shalygin; Institute of Cytology, Russian Academy of Sciences; St. Petersburg, Russia
Endogenous Store-operated Calcium Channels Regulated by STIM2 Proteins in HEK293 Cells - Bernard T. Drumm; University of Nevada Reno; Reno, Nevada, USA
The Role of Ca2+ Influx in Spontaneous Ca2+ Wave Propagation in Interstitial Cells of Cajal from the Rabbit Urethra
Session 9 - Immune Response - 2:30 pm
Michael Lenardo, Session Chair
- Michael Lenardo, M.D.; National Institute of Allergy and Infectious Diseases; Bethesda, Maryland, USA
Mg2+ as a second messenger revealed by a human immunodeficiency - Anjana Rao, Ph.D.; La Jolla Institute for Allergy & Immunology; La Jolla, California, USA
Opposing transcriptional programs driven by calcium, calcineurin and NFAT in T cells - Eric Skaar, Ph.D.; Vanderbilt University; Nashville, Tennessee, USA
The battle for metal between bacterial pathogens and their hosts - Veronique Schenten; University of Luxembourg; Luxembourg
Regulation of the Neutrophil NADPH Oxidase and Release of S100A8/A9 - Anne Bresnick; Albert Einstein College of Medicine; New York, New York, USA
Regulation of Macrophage Motility and Invasion by S100A4
Closing Plenary Lecture - 4:30 pm
Richard W. Tsien, Ph.D.; New York University; New York, New York, USA
Multiple roles of calmodulin in tuning cellular function and learning and memory
Ernesto Carafoli, Session Chair
Wednesday, June 3 - 8:45am - 1:00pm
Session 10 - Calcineurin - 8:45 am
Claude Klee, Session Chair
- Mark Dell'Acqua, Ph.D.; University of Colorado School of Medicine; Aurora, Colorado, USA
Calcineurin regulation of neuronal calcium channel activity and signaling to the nucleus - Trevor Creamer, Ph.D.; University of Kentucky College of Medicine; Lexington, KY, USA
Disorder in calcineurin activation - Gabriela Caraveo-Piso, Ph.D.; MIT; Cambridge, Massachusetts, USA
FKBP12 determines calcineurin substrate selection: implications to synucleinopathies - Cecilia Andresen; Linkoping University; Linkoping, Sweden
Characterization of Structure, Dynamics and Calcium Binding of Plasmodium falciparum CDPK3 - Yuya Fujiwara; Okayama University; Okayama City, Japan
Analysis of Distinct Roles of CaMKK Isoforms Using STO-609-Resistant Mutants in Living Cells
Session 11 - Neurological Diseases - 10:45 am
Jacek Kuznicki, Session Chair
- Grace E. Stutzman, Ph.D.; Rosalind Franklin University; North Chicago, Illinois, USA
Upregulated Ryanodine Receptor Activity Underlies Alzheimer's Disease Pathology from Molecular to Network Levels - Victoria Bolotina, Ph.D.; Boston University; Boston, Massachusetts, USA
Novel Calcium Signaling Root of Parkinson's Disease - Jacek Kuznicki, Ph.D.; International Institute of Molecular and Cell Biology; Warsaw, Poland
In search for models of sporadic Alzheimer's disease - Kazunori Kanemaru; University of Tokyo; Tokyo, Japan
New Calcium Imaging Methods for the Visualization of Local Activities of Astrocytes in vivo - Maria Ryazantseva; Institute of Cytology, Russian Academy of Sciences; St. Petersburg, Russia
Familial Alzheimer's Disease Mutation in Presenilin-1 Gene Leads to an Abnormal Store-operated Calcium Channels Activity Involved in the Memory Loss