Calmodulin Isoform
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Target Protein
|
Evidence of Interaction
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Effect of Interaction
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isoform 1
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calmodulin-dependent cyclic nucleotide phosphodiesterase
(PDE)
|
- biochemical evidence in Bos taurus: A peptide derived from the putative calmodulin-binding domain of PDE was show to bind to calmodulin (InfoCard)
- biochemical evidence in Bos taurus: Calmodulin stimulates phosphodiesterase activity (InfoCard)
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isoform 1
|
caldesmon
|
- spectroscopic evidence in Gallus gallus: Nuclear magnetic resonance studies demonstrate the ability of peptides derived from the clamodulin-binding domains fo caldesmon to bind to calmodulin (InfoCard)
- biochemical evidence in Gallus gallus: Calmodulin binding prevents the interaction of caldesmon with F-actin, removing the inhibition of the actomyosin ATPase by caldesmon (InfoCard)
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- in Gallus gallus: Calmodulin binding prevents the interaction of caldesmon with F-actin, removing the inhibition of the actomyosin ATPase by caldesmon (InfoCard)
|
isoform 1
|
calcineurin
|
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isoform 1
|
erythrocyte calcium-ATPase
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- biochemical evidence in Bos taurus: Calmodulin stimulates ATPase activity, and chemical modifications of calmodulin's methionines reduced this ability (InfoCard)
- biochemical evidence in Bos taurus: Calmodulin stimulates ATPase activity (InfoCard)
|
|
isoform 1
|
adenylate cyclase
|
- biochemical evidence in Bos taurus: A peptide derived from the putative calmodulin-binding domain of adenylate cyclase was shown to bind calmodulin (InfoCard)
|
|
isoform 1
|
calcium/calmodulin-dependent protein kinase II
(CaMKII)
|
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isoform 1
|
phosphorylase kinase
|
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isoform 1
|
nicotinamide dinucleotide kinase
|
- biochemical evidence in Pisum sativum: Purified NAD kinase absolutely requires calmodulin in order to function (InfoCard)
- biochemical evidence in Pisum sativum: NAD kinase is absolutely dependent on calmodulin and micromolar levels of free calcium for activity (InfoCard)
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- in Pisum sativum: NAD kinase is absolutely dependent on calmodulin and micromolar levels of free calcium for activity (InfoCard)
|
isoform 1
|
brush border myosin I heavy chain
|
- biochemical evidence in Gallus gallus: Calmodulin immobilized on coverslips translocates actin filaments (InfoCard)
- biochemical evidence in Gallus gallus: Calmodulin functions as the light chains for this myosin, and is responsible for the calcium-dependence of the ATPase activity (InfoCard)
|
- in Gallus gallus: Calmodulin functions as the light chains for this myosin, and is responsible for the calcium-dependence of the ATPase activity (InfoCard)
|
isoform 1
|
smooth muscle myosin light chain kinase
(smMLCK)
|
- biochemical evidence in Gallus gallus: A peptide derived from the putative calmodulin-binding domain of MLCK was shown to bind calmodulin (InfoCard)
- biochemical evidence in all vertebrates: Calmodulin binding stimulates kinase activity (InfoCard)
|
- in all vertebrates: Calmodulin binding stimulates kinase activity (InfoCard)
|
isoform 1
|
skeletal muscle myosin light chain kinase
(skMLCK)
|
- biochemical evidence in all vertebrates: Calmodulin binding stimulates kinase activity (InfoCard)
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- in all vertebrates: Calmodulin binding stimulates kinase activity (InfoCard)
|
isoform 1
|
neuronal nitric oxide synthase
(nNOS)
|
- biochemical evidence in Bos taurus: A peptide derived from the putative calmodulin-binding domain of NOS was shown to bind calmodulin (InfoCard)
|
|
isoform 1
|
calcium/calmodulin-dependent protein kinase IV
(CaMKIV)
|
|
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isoform 1
|
IQGAP1
|
- biochemical evidence in Homo sapiens: Affinity chromatography demonstrates that IQGAP1 binds to calmodulin-Sepharose in a calcium-dependent manner. IQGAP1 co-immunoprecipitates with calmodulin from malignant human breast epithelial cells. (InfoCard)
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isoform 1
|
phosphatidylinositol 3-kinase
|
- biochemical evidence in Cricetulus griseus: Affinity chromatography demonstrates that PI3-Kinase binds to calmodulin-Sepharose. PI3-Kinase co-immunoprecipitates with calmodulin from Chinese hamster ovary cells. (InfoCard)
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