Information in the EF-Hand Calcium-Binding Proteins Database from Reference 707

Protein	Species	Information	Submitted By	Validated By
S100A7	Homo sapiens (human)	This protein binds 1 equivalents of Zn ion	Ditlev E. Brodersen Aarhus University, Department of Institute of Molecular and Structural Biology ding@imsb.au.dk	Melanie R. Nelson mnelson@scripps.edu
S100A7	Homo sapiens (human)	structure by x-ray crystallography (pdb entry 2PSR) of homodimer bound to 2 ions of Ca	Melanie R. . Nelson, The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
S100A7	Homo sapiens (human)	structure by x-ray crystallography (pdb entry 3PSR) of homodimer, zinc bound to monomer A only bound to 2 ions of Ca	Melanie R. . Nelson, The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
S100A7	no species information	The conformational change between one calcium ion bound and one zinc ion bound and one calcium ion bound states involves: Asp 24 (which is part of the N-terminal EF-hand loop and binds zinc) turns away from the zinc-binding site and imposes a conformational change in the otherwise distorted EF-loop that causes it to resemble a calcium-bound loop. Thus, binding/release of zinc from the protein could have an impact on the calcium affinity.	Ditlev E. Brodersen Aarhus University, Department of Institute of Molecular and Structural Biology ding@imsb.au.dk	Melanie R. Nelson mnelson@scripps.edu