| Protein |
Species |
Information |
Comment |
Submitted By |
Validated By |
|---|---|---|---|---|---|
| calmodulin isoform 1 the main isoform, and the only isoform found in most species |
Homo sapiens (human) |
Report of an engineered mutant with following mutations:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 the main isoform, and the only isoform found in most species |
Homo sapiens (human) |
Report of an engineered mutant with following mutations:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Homo sapiens (human) |
This mutant forms a disulfide bond that prevents helices I and II of the N domain from moving apart. It fully recovers activity when the disulfide bond is reduced and the cysteines blocked by carboxyamidomethylation | Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Homo sapiens (human) |
This mutant forms a disulfide bond that prevents helices III and IV of the C domain from moving apart. This mutant shows decreases Ca2+ affinity in the C domain binding loops, as followed by intrinsic tyrosine fluorescence. It partially recovers activity when the disulfide bond is reduced and the cysteines blocked by cyanylation | Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Homo sapiens (human) |
Information about the activation of calmodulin-dependent cyclic nucleotide phosphodiesterase by this protein:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Homo sapiens (human) |
Information about the activation of calmodulin-dependent cyclic nucleotide phosphodiesterase by this protein:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Homo sapiens (human) |
Information about the activation of calcineurin by this protein:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Homo sapiens (human) |
Information about the activation of calcineurin by this protein:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |