CaBP Data Library General Information

Information in the EF-Hand Calcium-Binding Proteins Database from Reference 392

Protein
 Species
 Information
 Comment
 Submitted By
 Validated By
calbindin D9k
mutant:
  • P43G
this mutant is often used in NMR studies to substitute for wildtype, because it removes the problem of two sets of signals arising due to cis-trans isomerization at P43
 Bos taurus
(cow or bovine)
 structure by NMR (pdb entry 1CLB) of full length protein
    		Melanie R. Nelson
    The Scripps Research Institute, Department of Molecular Biology
    mnelson@scripps.edu
    		 Melanie R. Nelson
    mnelson@scripps.edu
    calbindin D9k
    		 no species information The conformational change between apo and two calcium ions bound states involves:
    • The conformational change is very minor. The overall fold remains the same. There are some changes in the packing of helix IV.
    		 Other papers which discuss and describe the calcium-induced conformational changes in calbindin D9k include: [ref_num 8 ] [ref_num 391]
    		 Melanie R. Nelson
    The Scripps Research Institute, Department of Molecular Biology
    mnelson@scripps.edu
    		 Melanie R. Nelson
    mnelson@scripps.edu