Calmodulin Mutant: Q41C + K75C

Engineered mutant of isoform 1 calmodulin, from Homo sapiens (InfoCard)

General Effects of the Mutation:

• This mutant forms a disulfide bond that prevents helices I and II of the N domain from moving apart. It fully recovers activity when the disulfide bond is reduced and the cysteines blocked by carboxyamidomethylation (InfoCard)

Physical Properties of the Mutant:

No physical properties of this mutant are currently stored in the database

Target Activation