Information from the EF-Hand CaBP Database about Calmodulin Mutant M144R + M145L

Engineered mutant of isoform 1 calmodulin, from Bos taurus (InfoCard)

This mutant is almost completely unable to activate PDE, despite the fact that the single mutant M145L activates PDE nearly as well as wildtype CaM does (InfoCard)

No physical properties of this mutant are currently stored in the database

	Target Protein	Acitivation Ability	Percent Activation (compared to wt)	K(act) (nM)	V(max)
M144R + M145L	calmodulin-dependent cyclic nucleotide phosphodiesterase	no (InfoCard)