Calmodulin Mutant: M36L + M51L
Engineered mutant of isoform 1 calmodulin, from Bos taurus (InfoCard)
Similar Mutants:
General Effects of the Mutation:
- This mutant is able to activate PDE fully, but must be present at higher concentrations than wildtype CaM needs to be to activate PDE fully. This double mutant activates PDE better than the single mutant M36L, which cannot fully activate PDE (InfoCard)
Physical Properties of the Mutant:
No physical properties of this mutant are currently stored
in the database
Target Activation
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Target Protein
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Acitivation Ability
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Percent Activation
(compared to wt) |
K(act)
(nM)
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V(max)
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M36L + M51L
|
calmodulin-dependent cyclic nucleotide phosphodiesterase
|
yes
(InfoCard)
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