Information from the EF-Hand CaBP Database about Calmodulin Mutant R126K

Engineered mutant of isoform 1 calmodulin, from Bos taurus (InfoCard)

Shows near wildtype ability to activate myosin light chain kinase (98% of max), but slightly reduced ability to activate nitric oxide synthase (88% of max) (InfoCard)

No physical properties of this mutant are currently stored in the database

	Target Protein	Acitivation Ability	Percent Activation (compared to wt)	K(act) (nM)
R126K	smooth muscle myosin light chain kinase	yes (InfoCard)	98 % (InfoCard)
wildtype from Bos taurus		yes (InfoCard)	100 % (InfoCard)	1.5 (InfoCard)

R126K	neuronal nitric oxide synthase	partial (InfoCard)	88 % (InfoCard)