Biomolecular Structure, Dynamics, and Function:
Membrane Proteins

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Friday, May 2

8:00 Registration and Coffee

Session 1

9:00: Welcome (Jens Meiler)

9:15 Mei Hong, Iowa State University/Massachusetts Institute of Technology
Conformation and Dynamics of the Membrane-Interacting Domains of a Viral Fusion Protein from Solid-State NMR

9:45 Timothy Cross, Florida State University
Small Helical Membrane Protein Structural Characterization & Functional Insights in Lipid Bilayers

10:15 Kathleen Howard, Swarthmore College
Probing the Conformation and Dynamics of Influenza A M2 Protein Using Site-Directed Spin Label EPR Spectroscopy

10:30 Francisco Barrera, University of Tennessee
An Intermediate in The Membrane Insertion of pHLIP: Stabilization of a Significantly Disordered Transmembrane State

10:45-11:15 Coffee Break

Session 2

11:15 David Akopian, Caltech
The Novel Function of a Protein-Conducting Channel in Cotranslational Protein Targeting

11:30 Terunaga Nakagawa, Vanderbilt University
Investigating Glutamate Receptor Complexes by Single Particle EM

12:00 R. Blake Hill, Medical College of Wisconsin
C'mon In, The Membrane's Fine! Protein Amphitropism in Mitochondrial Fission

12:15 Sponsor Presentations (5 minutes each)

12:45-1:45 Lunch

Session 3

1:45 Merritt Maduke, Stanford University
Dynamics of CLC Cl-/H+ Transporters

2:15 Wade Van Horn, Arizona State University
The Role of the TRPM8 Voltage-Sensing Domain in Thermosensation

2:30 Michael Wiener, University of Virginia (Keynote I)
The CaaX Protease Ste24p: Novel Structure Begets Novel Mechanism?

3:15-3:45 Coffee Break

Session 4

3:45 Katherine Henzler-Wildman, Washington University
NMR Perspectives on Multidrug Transport by EmrE

4:15 Hassane Mchaourab, Vanderbilt University
Mapping Transporter Conformational Dynamics using Double Electron Electron Spectroscopy (DEER)

4:45 Larry DeLucas, University of Alabama
A Novel Membrane Protein Solubility/Stability Technology

5:15 Changlin Tian, University of Science and Technology of China and High Magnetic Field Laboratory, Hefei
In Situ Membrane Protein Structure and Function Analysis using Site-Specific Isotope Incorporation and NMR

5:30-8:00 Poster Session and Dinner

8:00 Poster Finalist Short Talks (Poster Hall)

8:30-11:30 Mix and Dance (DJ: Prof. Puck Ohi)

Saturday, May 3

8:30 Coffee

Session 5

9:00 Julien Roche, Laboratory of Chemical Physics, NIDDK, NIH
gp41 Ectodomain Dissociates and Forms a stable Monomer on Phospholipid Vesicles and Detergent Micelles: Implication for the HIV-1 Env-Mediated Membrane Fusion

9:15 Richard Simmerman, University of Tennessee-Knoxville
Engineering Photosystem I Complexes for Use in Hybrid Dye-Sensitized Solar Cells

9:30 Melanie Ohi, Vanderbilt University
Structural Analysis of H. pylori VacA, A Pore Forming Toxin

10:00 Natalia Jura, University of California-San Francisco
Regulation of Allosteric Function of the HER/ErbB Receptors

10:30-11:00: Coffee Break

Session 6

11:00 Fang Tian, Penn State University College of Medicine, Hershey
Molecular Insights into the Recognition of Cellular Membrane Geometry

11:15 Heather Pinkett, Northwestern University
Deciphering the Mechanism of Molybdate ABC Importers in Bacteria

11:45 Stephen Sligar, University of Illinois
Revealing the Structure and Function of Membrane Proteins Through Nanotechnology

12:00 Jonathan Sachs, University of Minnesota
TNF-Receptor Networks Confer Higher Level of Function

12:30-3:00: Lunch and Poster Session 2 (with coffee)

3:00: Poster Finalist Short Talks (Poster Hall)

Session 7

3:30 Gary Lorigan, Miami University of Ohio
Investigating the Structural and Dynamic Properties of KCNE1 in Lipid Bilayers

4:00 Kristin Nuzzio, University of Illinois
Elucidating the Structure and Functional Dynamics of Membrane Tissue Factor by Solid-State NMR

4:15 Jere Segrest, University of Alabama-Birmingham
Homology Modelling Generates a Robust Structure-Function Model for Human Lecithin:Cholesterol Acyltransferase

4:30 James Prestegard, University of Georgia (Keynote II)
Protein-Protein Interactions at a Membrane Surface – NMR of the ARF1-FAPP1 System

6:00 Drinks and Dinner at Bound'ry

Optional After Dinner: Explore Nashville

Sunday, May 4

8:30 Coffee

Session 8

9:00 Vsevolod Gurevich, Vanderbilt University
Structure of an Arrestin-GPCR Complex: Insights and Caveats

9:30 Petra Fromme, Arizona State University (Keynote III)
Femtosecond Crystallography: A New Avenue for Structure Determination of Membrane Proteins

10:15-10:45 Coffee Break

Session 9

10:45 Oliver Zerbé, University of Zurich
Towards Structure and Folding of GCPRs Using Large Fragments

11:00 Abby Parrill, University of Memphis
Progress Toward A Transferable Water Soluble GPCR Design

11:15 Ron Dror, Stanford University
Structural Basis for Allosteric Modulation of a GPCR

11:45 Tina Iverson, Vanderbilt University
Membrane Protein Structures Are Getting a Little More Complex

12:15 Farewell and Box Lunches

The BSDF conference is supported by:
National Institute of General Medical Sciences (grant R13GM096562) to Jere Segrest, M.D., Ph.D. (Univ. Alabama at Birmingham) and and Stephen C. Harvey (Georgia Institute of Technology)

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