AMBER Archive (2009)

Subject: Re: [AMBER] Ki and G

From: case (case_at_biomaps.rutgers.edu)
Date: Mon Sep 14 2009 - 12:23:49 CDT

On Mon, Sep 14, 2009, Marek Maly wrote:

> Thomas is explicitly speaking about free ENTHALPY of binding, although
> Bill is asking about relationship of the total free ENERGY of binding

Strictly speaking (which is what Thomas was doing), G is "free enthalpy"
and A is "free energy".

However, widely in the literature, the term "free energy" is used to
mean either G or A (where the context is used to make the distinction), and
the term "free enthalpy" is much less commonly used. Note that in nearly
incompressible liquids like water, G and A are almost the same, which is why
"free energy" can often be used to refer to either one of these.

Don't confuse, however free enthalphy (G) with enthalpy (H).

...hope this helps...dac

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