AMBER Archive (2001)

Subject: Non-standard DNA bases

From: J Suggs (J_Suggs_at_Brown.edu)
Date: Tue Jun 12 2001 - 18:32:21 CDT

Dear AMBER users,

        We would be interested in opinions on the best way to build
DNA duplexes with one or more unusual bases (for example,
3-nitropyrrole). Especially, is there anything particularly tricky
about modifying Nucgen so that it takes more than four bases?

Thanks,
Bill Suggs
Brown, Chemistry and Biochemistry