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An Introductory Workshop to the Rosetta Protein Modeling Suite

Upcoming Workshops

The next RosettaWorkshop is tentatively planned for the week of April 29th, 2019.

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Workshop Goals

The goal of the Rosetta Workshops are to educate and train academic and industry users on the Rosetta software suite. Rosetta is freely distributed to the academic community by RosettaCommons. The workshop will be catered towards attendees' needs, and time is allocated to address research questions presented by attendees. Join the Meiler Lab for our semi-annual Rosetta Workshop!

ROSETTA Software

Rosetta is a unified software package for protein structure prediction and functional design. It has been used to predict protein structures with and without the aid of sparse experimental data, perform protein-protein and protein-small molecule docking, design novel proteins and redesign existing proteins for altered function. Rosetta allows for rapid tests of hypotheses in biomedical research which would be impossible or exorbitantly expensive to perform via traditional experimental methods. Thereby, Rosetta methods are becoming increasingly important in the interpretation of biological findings, e.g., from genome projects and in the engineering of therapeutics, probe molecules and model systems in biomedical research (Bender et al. "Protocols for Molecular Modeling with Rosetta3 and RosettaScripts." Biochemistry 2016.)

Workshop Materials

Materials from previous workshops, including full instructions, example inputs and representative output, can be obtained from the Meiler Lab website. The Rosetta Software itself can be obtained through the RosettaCommons website. The tutorial examples from the workshop have been published in two previous papers in the journal Biochemistry: Bender et al. (2016) "Protocols for Molecular Modeling with Rosetta3 and RosettaScripts." doi:10.1021/acs.biochem.6b00444 and Kaufmann et al. (2010) "Practically useful: what the Rosetta protein modeling suite can do for you." doi:10.1021/bi902153g.

Previous Workshops

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The Rosetta Workshop is supported in part by NIH NIGMS R01 GM073151 ("Rosetta: An Integrated Macromolecular Modeling Suite") and by the RosettaCommons.