B.D. Corbin, E.H. Seeley, A. Raab, J. Feldman, M.R. Miller, V.J. Torres, K.L. Anderson, B.M. Datillo, P.M. Dunman, R. Gerads, R.M. Caprioli, W. Nacken, W.J. Chazin, and E.P. Skaar. "Metal chelation and inhibition of bacterial growth in tissue abscesses." Science 319, 962-965 (2008).

S. Ghavami, C. Kerkhoff, W.J. Chazin, K. Kadkhoda, W. Xiao, M. Hashemi, M. Eshraghi, A. Zuse, and M. Los. "Cell death signaling pathway of S100A8/A9: Role of RAGE and mitochondrial pathway." J. Leukocyte Biol. in press (2008).

S. Ghavami, C. Kerkhoff, W.J. Chazin, K. Kadkhoda, W. Xiao, A. Zuse, M. Hashemi, M. Eshraghi, K. Schulze-Osthoff, ; T. Klonisch and M. Los. "S100A8/9 Induces Cell Death via a Novel, RAGE-independent Pathway that Involves Selective Release of Smac/DIABLO and Omi/HtrA2." BBA- Mol. Cell Res. 1783, 297-311 (2008).

W.J. Chazin. "Evolution in the NIGMS Protein Structure Initiative" Structure 16, 12-14 (2008).

B.E. Weiner, H. Huang, B.M. Dattilo, M.J. Nilges, E. Fanning, and W.J. Chazin. "An iron-sulfur cluster in the C-terminal domain of the p58 subunit of human DNA primase." J. Biol. Chem. 282, 33444-33451 (2007).

H.L. Ball, M.R. Ehrhardt, D.A. Mordes, G.G. Glick, W.J. Chazin and D. Cortez. "Function of a Conserved Checkpoint Recruitment Domain in ATRIP Proteins." Mol. Cell Biol. 27, 3367-3377 (2007).

W.J. Chazin. "The impact of X-ray crystallography and NMR on intracellular calcium signal transduction by EF-hand proteins: Crossing the threshold from structure to biology and medicine." Science STKE 388, pe27 (3 pages) (2007).

M. Koch, S. Bhattacharya, T. Kehl, M. Gimona, M. Vašák, W. Chazin, C.W. Heizmann, P.M.H. Kroneck, and G. Fritz. "Implications of Zinc Binding to S100A2." BBA Mol. Cell Res. 1773,457-470 (2007).

B.M. Dattilo, G. Fritz, E. Leclerc, C.W. Heizmann, C.W. Vander Kooi, and W.J. Chazin. "The Extracellular Region of the Receptor for Advanced Glycation Endproducts is Composed of Two Independent Structural Units." Biochemistry 46, 6957-6970 (2007).

C.G. Bunick, M.R. Miller, B.E. Fuller, E. Fanning and W.J. Chazin. "Biochemical and Structural Domain-Analysis of XPC." Biochemistry 45, 14965-14979 (2006).

X. Jiang, V. Klimovich, A.I. Arunkumar, E.B. Hysinger, Y. Wang, R.D. Ott, J. Ferguson, B. Weiner, W.J. Chazin* and E. Fanning*. "Structural mechanism of helicase-mediated RPA loading on DNA during activation of a simple pre-replication complex." EMBO J. 25, 5516-5526 (2006).

M. Koch, S. Bhattacharyya, T. Kehl, M. Gimona, M. Vasak, W.J. Chazin, C.W. Heizmann, P.M.H. Kroneck, and G. Fritz. "Implications of Zinc Binding to S100A2." BBA Mol. Cell Res.

V.N. Shah, B. Chagot and W.J. Chazin. "Calcium-Dependent Regulation of Ion Channels." Calcium Binding Proteins 1, 213-218 (2006).

K. Sunahori, M. Yamamura, J. Yamana, K. Takasugi, M. Kawashima, H. Yamamoto, W.J. Chazin, Y. Nakatani, S. Yui, and H. Makino. "The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis." Arthritis Res Ther. 8, R39 (12 pages) (2006).

C.W. Vander Kooi, M.D. Ohi, J.A. Rosenberg, M.L. Oldham, M.E. Newcomer, K.L. Gould, and W.J. Chazin. "The Prp19 U-box U-box Crystal Structure Suggests a Common Architecture for a Class of Oligomeric E3 Ubiquitin Ligases." Biochemistry 45, 121-130 (2006).

J.H. Sheehan, C.G. Bunick, H. Hu, P.A. Fagan and W.J. Chazin. "Structure of the N-terminal Calcium Sensor Domain of Centrin Reveals the Biochemical Basis for Domain-Specific Function." J. Biol. Chem. 281, 2876-2881 (2006).

S.M. Meyn, C. Seda, M. Campbell, K.L. Weiss, H. Hu, B. Pastrana-Rios and W.J. Chazin. "The biochemical effect of Ser167 phosphorylation on chlamydomonas rheinhardti centrin." Biochem. Biophys. Res. Commun. 342, 342-348 (2006).

V. Chandran, E.J. Stollar, K. Lindorff-Larsen, J.F. Harper, W.J. Chazin, C.M. Dobson, B.F. Luisi and J. Christodoulou. "Structure of the regulatory apparatus of a calcium-dependent protein kinase (CDPK): a novel mode of calmodulin-target recognition." J. Mol. Biol. 357, 400-410 (2006).

E. Johnson, W.J. Chazin and M. Rance. "Effects of Calcium Binding on the Side-chain Methyl Dynamics of Calbindin D9k: A 2H NMR Relaxation Study." J. Mol. Biol. 357, 1237-1252 (2006).

V.N. Shah, T.L. Wingo, K.L. Weiss, C.K. Williams, J.R. Balser and W.J. Chazin. "Calcium-dependent regulation of the cardiac voltage-gated sodium channel hH1: Intrinsic and extrinsic sensors act through a common molecular switch." Proc. Natl. Acad. Sci., USA 103, 3592-3597 (2006).

A.I. Arunkumar, V. Klimovich, X. Jiang, R.D. Ott, L. Mizoue, E. Fanning and W.J. Chazin. "Insights into RPA32 C-terminal domain-mediated assembly of the simian virus 40 replisome." Nature Structural Molecular Biology 12, 332-339 (2005).

M.D. Ohi, C.W. Vander Kooi, J.A. Rosenberg, L. Ren, J.P. Hirsch, W.J. Chazin, T. Walz, and K.L. Gould. "Prp19p tetramerization is required for pre-mRNA splicing." Mol. Cell Biol. 25, 451-460 (2005).

C. Bunick, W.J. Chazin. "Two Blades of the [Ex]Scissor." Structure 13, 1740-1741 (2005).

S. Bhattacharya, Y.-T. Lee, M. Novotny, J. Kuznicki and W.J. Chazin. "The modular structure of SIP facilitates its role in stabilizing multi-protein assemblies." Biochemistry 44, 9462-9471 (2005).

B.T. Vander Kooi, J.K. Oeser, C.A. Svitek, S.R. Allen, C.W. Vander Kooi, W.J. Chazin and R.M. OBrien. "Characterization of the Glucose-6-Phosphatase Catalytic Subunit Proximal Glucocorticoid Response Unit." Molecular Endocrinology 19, 3001-3022 (2005).

A. Malmedal, C.W. Vander Kooi, N.C. Nielson and W.J. Chazin. "Calcium-modulated S100 protein-phospholipid interactions. An NMR study of calbindin D9k and DPC." Biochemistry 44, 6502-12 (2005).

Y. Nakatani, M. Yamazaki, W.J. Chazin and S. Yui. "Regulation of S100A8/A9 (Calprotectin) Binding to Tumor Cells by Zinc Ion and its implication for apoptosis-inducing activity." Mediators of Inflammation 5, 280-92 (2005).

M. Ortiz, Z. Sanoguet, H. Hu, W.J. Chazin, C. McMurray, J.L. Salisbury and B. Pastrana-Rios. "Dynamics of Hydrogen/Deuterium Exchange in Chlamydomonas Centrin." Biochemistry 44, 2409-2418 (2005).

T.L. Wingo, V.N. Shah, M.E. Anderson, T.P. Lybrand, W.J. Chazin* and J.R. Balser*. "An EF-Hand in the sodium channel couples intracellular calcium to cardiac excitability." Nature Structural Molecular Biology 11, 219-225 (2004).

Y.-T. Lee, J. Jacob, W. Michowski, M. Nowotny, J. Kuznicki and W.J. Chazin. "Human Sgt1 binds to HSP90 through its CS domain: CS domain is a general binding module for HSP90." J. Biol. Chem. 279, 16511-16517 (2004).

S. Bhattacharya, A.I. Arunkumar and W.J. Chazin. "1H, 15N and 13C assignments of the tandem high affinity ssDNA binding domains of replication protein A." J. Biomolec. NMR 28, 195-196. (2004).

C.G. Bunick, M.R. Nelson, S. Mangahas, M.J. Hunter, J.H. Sheehan, L.S. Mizoue, G.J. Bunick and W.J. Chazin. "Designing sequence to control function in an EF-hand Protein." J. Amer. Chem. Soc. 126, 5990-5998 (2004).

M.E. Stauffer and W.J. Chazin. "Structural Mechanisms of DNA Replication, Recombination, and Repair." J. Biol. Chem. 279, 30915-30918 (2004).

M.E. Stauffer and W.J. Chazin. "Physical Interaction between RPA and Rad51 is Essential for Efficient Initiation of Recombination." J. Biol. Chem. 279, 25638-25645 (2004).

H. Hu, J.H. Sheehan and W.J. Chazin. "The Mode of Action of Centrin: Binding of Ca2+ and a Peptide Fragment of Kar1p to the C-terminal Domain." J. Biol. Chem. 279, 50895-50903 (2004).

J. Christodoulou, J.F. Harper, A. Malmendal and W.J. Chazin. "Insights into the Regulation of Calcium-Dependent Protein Kinase (CDPK) by Calcium and the Autoinhibitory Junction." J. Biol. Chem. 279, 29092-29100 (2004).

H. Highfield-Nickols, V.N. Shah, W.J. Chazin, and L.E. Limbird. "Calmodulin interacts with the V2 vasopressin receptor: Elimination of binding to the C-terminus also eliminates AVP-stimulated elevation of intracellular calcium." J. Biol. Chem. 279, 46969-46980 (2004).

S. Bhattacharya, C.G. Bunick, and W.J. Chazin. "Target Selectivity in EF-hand Calcium Binding Proteins." BBA-Molecular Cell Res. 1742, 69-79 (2004).

S. Bhattacharya, E. Large, C.W. Heizmann, B. Hemmings and W.J. Chazin. "Structural mechanism of calcium dependent regulation of the NDR Kinase by S100B." Biochemistry 42, 14416-14426 (2003).

A.I. Arunkumar, M.E. Stauffer, E. Bochkareva, A. Bochkarev, and W.J. Chazin . "Independent and coordinated functions of the Replication Protein A tandem high affinity ssDNA binding domains." J. Biol. Chem. 278, 41077-41082 (2003).

C. Bassarello, P. Cimino, G. Bifulco, D.L. Boger, J.A. Smith, W.J. Chazin and L. Gomez-Paloma. "NMR Structure of the (+)-CPI-indole/d(GACTAATTGAC)-d(GTCAATTAGTC) Covalent Complex." Chem. Biochem. 4, 1188-1193 (2003).

S. Bhattacharya and W.J. Chazin. "Calcium Driven Changes in S100A11 Structure Revealed."Structure 11, 738-740 (2003).

J.-H. Lee, C.-J. Park, A.I. Arunkumar, W.J. Chazin and B.-S. Choi. "NMR study on the interaction between RPA and DNA decamer-containing cis-syn cyclobutane pyrimidine dimer in the presence of XPA: Implication for damage verification and strand-specific dual incision in nucleotide excision repair." Nucleic Acids Research 31, 4747-4754 (2003).

H. Hu and W.J. Chazin. "Unique Features in the C-terminal Domain Provide Caltractin with Target Specificity." J. Mol. Biol. 330, 473-484 (2003).

M.D. Ohi, C.W. Vander Kooi, J.A. Rosenberg, W.J. Chazin and K. L. Gould."Structural Insights Into the U-box, A Domain Associated with Multi-Ubiquitination."Nature Structural Biol. 11, 250-255(2003).

A. Malmendal, S. Halpain and W.J. Chazin."Biophysical Characterization of Protected Domains in Microtubule-Associated Protein 2."Biochem. Biophys. Res. Commun. 301, 136-142 (2003).

S. Bhattacharya, M.V. Botuyan, F. Hsu, X. Shan, A.I. Arun Kumar, C.H. Arrowsmith, A.M. Edwards and W.J. Chazin."Characterization of Backbone Dynamics Suggests a Model for Sequence Non-Specific Binding of ssDNA by Replication Protein A"Protein Science 11, 2316-2325 (2002).

J. Christodoulou, H. Hu, J. Chung, M. Rance, J.F. Harper and W.J. Chazin. "¹H, ¹⁵N and ¹³C assignments of the regulatory domains of calcium-dependent protein kinase (CDPK)."J. Biomolec. NMR, 23, 249-250 (2002).

S. Veeraraghavan, P.A. Fagan, H. Hu, V. Lee, J.F. Harper, B. Huang and W.J. Chazin. "Structural independence of the two EF-hand domains of caltractin." J. Biol. Chem., 277 28564-28571(2002).

L. Mizoue and W.J. Chazin. "Protein design of ligand-induced conformational control."Curr. Opinion in Structural Biology, 12 459-463 (2002).

S. Yui, Y. Nakatani, M.J. Hunter, W.J. Chazin and M. Yamazaki. "Implication of extracellular zinc exclusion by recombinant human calprotectin (MRP8 and MRP14) from target cells in its apoptosis-inducing activity."Mediators of Inflammation 11, 165 - 172 (2002).

M.R. Nelson, E. Thulin, P.A. Fagan, S. Forsén and W.J. Chazin. "The EF-hand domain: a globally cooperative structural unit." Protein Science 11, 198-205 (2002).

L. Mäler, M. Sastry and W.J. Chazin."Ca²⁺-induced structural changes in S100 proteins: High resolution solution structure of Ca²⁺bound calcyclin"J. Mol. Biol. 317, 279-290 (2002).

G. Bifulco, J. A. Smith, W. J. Chazin and L. Gomez-Paloma. "Molecular Basis for Recognition and Binding of Specific DNA Sequences by Calicheamicin and Duocarmycin."Advances in DNA Sequence-Specific Agents 4, 47-73 (2002).

M. Akke & W.J. Chazin. "An Open and Shut Case."Nature Struct. Biol. 8, 910-912 (2001).

A. Randazzo, C. Acklin, B.W. Shaefer, C.W. Heizmann and W.J. Chazin. "Structural insight into Zn²⁺-bound S100A2 from NMR and homology modeling." Biochem. Biophys. Res. Commun., 462-467 (2001).

M.V. Botuyan, G. Mer, G.S. Yi, C.M. Koth, D.A. Case, A.M. Edwards, W.J. Chazin and C.H. Arrowsmith. "Solution Structure of Yeast Elongin C in Complex with a VHL Peptide."J. Mol. Biol. 312, 177-186 (2001).

G. Mer, A. Bochkarev, R. Gupta, E. Bochkarev, L.D. Frappier, C.J. Ingles, A.M. Edwards and W.J. Chazin. "Structural Basis for the Recognition of DNA Repair Proteins UNG2, XPA, and RAD52 by Replication Factor RPA,"Cell 103, 449-456 (2000).

M. Nowotny, S. Bhattacharya, A. Filipek, W.J. Chazin, and J. Kuznicki. "Characterization of the interaction of calcyclin (S100A6) and calcyclin-binding protein."J. Biol. Chem. 275, 31178-31182 (2000).

P.G. Sohnle, M.J. Hunter, B. Hahn, and W.J. Chazin."Zinc-Reversible Antimicrobial Activity Recombinant Calprotectin (Migration Inhibitory FactorRelated Proteins 8 and 14)." J. Infectious Diseases 182, 1272-1275 (2000).

G. Mer, A.M. Edwards and W.J. Chazin. "1H, 13C, and 15N assignments of the C-terminal protein interaction region of the 32 kDa subunit of replication protein A."J. Biomolec. NMR 17, 179-180 (2000).

V. Vitart, J. Christodoulou, J.-F. Huang, W. J. Chazin and J. F. Harper. "Intramolecular Activation of a Ca²⁺-Dependent Protein Kinase Is Disrupted by Insertions in the Tether That Connects the Calmodulin-like Domain to the Kinase."Biochemistry 39, 4004-4011 (2000).

J.A. Smith, G. Bifulco, D.A. Case, D.L. Boger, L. Gomez-Paloma and W.J. Chazin. "The structural basis for in-situ activation of DNA alkylation by duocarmycin SA."J. Mol. Biol. 300, 1195-1204 (2000).

C.M. Koth, M.V. Botuyan, R. J. Moreland, D. Jansma, J.W. Conaway, R.C. Conaway, W.J. Chazin, J.D. Friesen, C.H. Arrowsmith and A.M. Edwards. "Elongins from Saccharomyces cerevisiae."J. Biol. Chem. 275,. 11174-11180 (2000).

L. Mäler, J. Blankenship, M. Rance and W.J. Chazin."Site-site Communication in the EF-hand Ca²⁺-binding protein calbindin D_9k,"Nature Structural Biol. 7, 245-250 (2000).

M.V. Botuyan, C.M. Koth, G. Mer, A. Chakrabatartty, J.W. Conaway, R.C. Conaway, A.M. Edwards, C.H. Arrowsmith & W.J. Chazin. "Binding of Elongin A or a von Hippel-Lindau Peptide Stabilizes the Structure of Yeast Elongin C,"Proc. Natl. Acad. Sci., USA 96, 9033-9038 (1999).

J. Schnell, R.R. Ketchem, D.L. Boger and W.J. Chazin."High resolution solution structure of a DNA duplex alkylated by the indole derivative of the antitumor agent duocarmycin SA."J. Amer. Chem. Soc. 121, 5645-5652 (1999).

N.J. Skelton and W.J. Chazin."Solution structure determination of proteins using NMR spectroscopy."In Peptide and Protein Analysis, R. Reid (ed.), Marcel Dekker, Inc., New York, 683-726 (1999).

T.D. Veenstra and W.J. Chazin."Determination of the metal-binding cooperativity of wild-type and mutant calbindin D_9k by electrospray ionization mass spectrometry." Rapid Commun. Mass Spectrom. 13, 548-555 (1999).

L. Mäler, B.C.M. Potts and W.J. Chazin."High resolution solution structure of apo calcyclin and structural variations in the S100 family of calcium-binding proteins."J. Biomol. NMR 13, 233-247 (1999).

M. Nelson and W.J. Chazin. "Structures of EF-hand Ca²⁺-binding Proteins: Diversity in the Organization, Packing and Response to Ca²⁺ Binding."Biometals 11, 297-318 (1998).

S.K. Wilcox, C.D. Putnam, M. Sastry, J. Blankenship, W.J. Chazin, D.E. McRee, and D.B. Goodin."Rational Design of a Functional Metalloenzyme: Introduction of a Site for Manganese Binding and Oxidation into a Heme Peroxidase."Biochemistry 37, 16853-16862 (1998).

G. Bifulco, A. Galeone, K.C. Nicolaou, W.J. Chazin and L. Gomez-Paloma."Solution structure of the complex between the head-to-tail dimer of calcicheamicin g₁^I oligosaccharide and a DNA duplex containing d(ACCT) and d(TCCT) high affinity binding sites." J. Amer. Chem. Soc. 120, 7183-7191 (1998).

M. Nelson and W.J. Chazin."Calmodulin as a calcium sensor."In Calmodulin and Signal Transduction, L.J. van Eldik & D.M. Watterson (eds.), Academic Press, Inc., pp. 17-64 (1998).

M.J. Hunter and W.J. Chazin."High level expression and dimer characterization of the S100 EF-hand proteins, migration inhibitory factor-related proteins 8 and 14."J. Biol. Chem. 273, 12427-12435 (1998).

B.B. Kragelund, M. Jönnson, G. Bifulco, W.J. Chazin, H. Nilsson, B.E. Finn and S. Linse."Hydrophobic core substitutions in calbindin D_9k. Effects on Ca²⁺-binding and dissociation."Biochemistry 37,8926-8937 (1998).

M. Sastry, R. R. Ketchem, O. Crescenzi, C. Weber, M.J. Lubienski, H. Hidaka and W.J. Chazin."The three-dimensional structure of Ca²⁺-bound calcyclin: Implications for Ca²⁺-signal transduction by S100 proteins."Structure 6, 223-231 (1998).

G. Mer and W.J. Chazin."Enzymatic synthesis of region-specific isotope-labeled DNA oligomers for NMR analysis."J. Amer. Chem. Soc. 120, 607-608 (1998).

M. Nelson and W.J. Chazin."An interaction-based analysis of calcium-induced conformational changes in Ca²⁺ sensor proteins." Protein Science 7, 270-282 (1998).

B.C. Potts and W.J. Chazin."Chemical shift homology in proteins."J. Biomolec. NMR 11, 45-57 (1998).

S.M. Miick, R.S. Fee, D.P. Millar and W.J. Chazin. "Crossover isomerization is the primary sequence-dependent property of the Holliday junction." Proc. Natl. Acad. Sci. USA 94, 9080-9084 (1997).

J. Kördel, D.A. Pearlman and W.J. Chazin."Protein solution structure calculations in solution: solvated molecular dynamics refinement of calbindin D_9k."J. Biomolec. NMR 10, 231-243 (1997).

P.S. Eis, J. Smith, J. Rydzewski, D.A. Case, D.L. Boger and W.J. Chazin."High resolution solution structure of a DNA duplex alkylated by the antitumor agent duocarmycin SA."J. Mol. Biol. 272, 237-252 (1997).

L.K. Lee, M. Rance, W.J. Chazin, and A.G. Palmer III. "Rotational diffusion anisotropy of proteins from simultaneous analysis of ¹⁵N and ¹³C^anuclear spin relaxation." J. Biomolec. NMR 9, 287-298 (1997).

J. Smith, L.G. Paloma, D.A. Case and W.J. Chazin. "Molecular dynamics docking driven by NMR derived restraints to determine the structure of the calicheamicin g₁^I oligosaccharide domain complexed to duplex DNA." Magn. Reson. Chem. 34:S, 147-155 (1996).

W.J. Chazin.Incorporating motional properties into the interpretation of three-dimensional solution structures.In NMR as a Structural Tool for Macromolecules: Current Status and Future Directions, B.D. Nageswara Rao & M.D. Kemple (eds.), Plenum Press, New York, pp. 77-86 (1996).

G. Bifulco, A. Galeone, L.Gomez-Paloma, K.C. Nicoloau and W.J. Chazin."Solution structure of the head-to-head dimer of the calicheamicin oligosaccharide domain and d(CGTAGGATATCCTACG)₂."J. Amer. Chem. Soc. 118, 8817-8824 (1996).

B.C. Potts, G. Carlström, K. Okazaki, H. Hidaka and W.J. Chazin."¹H NMR assignments of apo calcyclin and comparative structural analysis with calbindin D_9k and S100 b."Protein Science 5, 2162-2174 (1996).

G. Carlström and W.J. Chazin."Sequence dependence and direct measurement of crossover isomer distribution in model Holliday junction using NMR spectroscopy."Biochemistry 35, 3534-3544 (1996).

J. Rydzewski, W. Leupin and W.J. Chazin."The width of the minor groove affects the binding of the bisquaternary heterocycle SN-6999 to duplex DNA"Nucl. Acids Res. 24, 1287-1293 (1996).

W.J. Chazin."Releasing the calcium trigger." Nature Structural Biology 2, 707-710 (1995).

B.C. Potts, J. Smith, M. Akke, T.J. Macke, K. Okazaki, H. Hidaka, D.A. Case and W.J. Chazin."The Structure of calcyclin reveals a novel homodimeric fold for S100 Ca²⁺-binding proteins."Nature Structural Biology 2, 790-796 (1995).

M. Akke, S. Forsén and W.J. Chazin."Solution structure of (Cd²⁺)₁ calbindin D_9k reveals details of the stepwise structural changes along the apo->(Ca²⁺)₁^II->(Ca²⁺)₂^II,I binding pathway."J. Mol. Biol. 252, 102-121 (1995).

W.J. Chazin, G. Carlström, S.-M. Chen, S. Miick, L.G. Paloma, J. Smith and J. Rydzewski."Complex DNA Structures and Structures of DNA Complexes."Proceedings of the Symposium on Stable Isotope Applications in Biomolecular Structure & Mechanism, Santa Fe, NM, pp. 43-57 (1995).

B.T. Wimberly, E. Thulin, and W.J. Chazin."Characterization of the N-terminal half-saturated state of calbindin D_9k: NMR studies of the N56A mutant."Protein Science 4, 1045-1055 (1995).

S. Linse and W.J. Chazin."Quantitative measurements of the cooperativity in an EF-hand protein with sequential calcium binding."Protein Science 4, 1038-1044 (1995).

S. Miick, G. Carlström, S.-M. Chen and W.J. Chazin."NMR studies of synthetic models of the Holliday junction intermediate in genetic recombination."Meth. Enzym. 261, 163-182 (1995).

N.J. Skelton, J. Kördel and W.J. Chazin."Determination of the solution structure of apo calbindin D_9k by NMR spectroscopy."J. Mol. Biol. 249, 441-462 (1995).

S. Linse, B. Jönsson and W.J. Chazin."The effect of protein concentration on ion binding."Proc. Natl. Acad. Sci. USA 92, 4748-4752 (1995).

S.-M. Chen and W.J. Chazin."Two-dimensional ¹H NMR studies of immobile holiday junctions: Nonlabile proton assigments and identification of crossover isomers."Biochemistry 33, 11453-11459 (1994).

A.A. Kosiakoff and W.J. Chazin."The role of secondary and tertiary structure in intramolecular deamidation of proteins." In Deamidation and Isoaspartate Formation in Peptides and Proteins, D.W. Aswad (ed.), CRC Press, Inc., pp. 193-206 (1994).

C. Weber, V.D. Lee, W.J. Chazin and B. Huang."High level expression in Escherichia coli and characterization of the EF-hand calcium-binding protein caltractin."J. Biol. Chem. 269, 15795-15802 (1994).

L.G. Paloma, J. Smith, W.J. Chazin and K.C. Nicoloau."Interaction of calicheamicin and DNA: Role of the oligosaccharide domain and identification of multiple binding modes."J. Amer. Chem. Soc. 116, 3697-3708 (1994).

N.J. Skelton, J. Kördel, M. Akke, S. Forsén and W.J. Chazin."Signal transduction versus buffering activity in Ca²⁺ binding proteins."Nature Structural Biology 1, 239-245 (1994).

M. Akke, S. Forsén and W.J. Chazin. "¹⁵N NMR Assignments of (Cd²⁺)₂-calbindin D_9k and comparison with (Ca²⁺)₂-calbindin D_9k. Cadmium as a substitute for calcium in calcium-binding proteins."Magn. Reson. Chem. 31(S), 128-132 (1993).

M. Akke, N.J. Skelton, J. Kördel, A.G. Palmer, III and W.J. Chazin."Effects of ion binding on the backbone dynamics of calbindin D_9k determined by ¹⁵N NMR relaxation."Biochemistry 32, 9832-9844 (1993).

S. Forsén, J. Kördel, T. Grundström and W.J. Chazin."The molecular anatomy of a calcium-binding protein."Accounts of Chem. Res. 26, 7-14 (1993).

J. Kördel, N.J. Skelton, M. Akke and W.J. Chazin."High-resolution structure of calcium-loaded calbindin D_9k."J. Mol. Biol. 231, 711-734 (1993).

G. Carlström and W.J. Chazin."Two-dimensional ¹H nuclear magnetic resonance studies of the half-saturated (Ca²⁺)₁ state of calbindin D_9k: further implications for the molecular basis of cooperative Ca²⁺ binding." J. Mol. Biol. 231, 415-430 (1993).

N.J. Skelton, A.G. Palmer, III, M. Akke and W.J. Chazin."Practical aspects of ¹⁵N NMR relaxation measurements." J. Magn. Reson. 102B, 253-264 (1993).

S.-M. Chen, F.L. Heffron and W.J. Chazin."Two-dimensional ¹H NMR studies of 32-base-pair synthetic immobile holliday junctions: Complete assignments of the labileprotons and identification of the base-pairing scheme."Biochemistry 32, 319-326 (1993).

N.J. Skelton, J. Kördel, M. Akke and W.J. Chazin."Nuclear magnetic resonance studies of the internal dynamics in apo, (Cd²⁺)₁, and (Ca²⁺)₂ calbindin D_9k."J. Mol. Biol. 227, 1100-1117 (1992).

W.J. Chazin."NMR structure and methodology."Current Opinion in Biotechnology 3, 326-332 (1992).

J. Kördel, N.J. Skelton, A.G. Palmer, III and W.J. Chazin."Backbone dynamics of calcium-loaded bovine calbindin D_9k determined by ¹⁵N NMR relaxation." Biochemistry 31, 4856-4866 (1992).

S.-M. Chen,M. Rance, W. Leupin and W.J. Chazin."Two-dimensional NMR studies of d-(GGTTAATGCGGT)^.d-(ACCGCATTAACC) complexed with the minor groove binding drug SN-6999." Biochemistry 31, 4406-4413 (1992).

N.J. Skelton, M. Akke, J. Kördel, E. Thulin, S. Forsén and W.J. Chazin."¹⁵N assignments and chemical shift analysis of uniformly labeled calbindin D_9k in the apo, (Cd²⁺)₁, and (Ca²⁺)₂ states."FEBS Lett. 303, 136-140 (1992).

A.G. Palmer, III, N.J. Skelton, W.J. Chazin, P.E. Wright and M. Rance. "Suppression of the effects of cross-correlation between dipolar and anisotropic chemical shift relaxation mechanisms in the measurement of spin-spin relaxation rates."Mol. Phys. 75, 699-711 (1992).

T. Macke, S.-M. Chen, and W.J. Chazin."Analysis of the structure and dynamics of synthetic 32 base-pair models of the Holliday junction intermediate in genetic recombination." In Structure and Function vol. 1, M.H Sarma & R.H. Sarma (eds.), Adenine Press Inc., Guilderland, N.Y., pp. 213-228 (1992).

S.-M. Chen, W. Leupin and W.J. Chazin."Conformational studies of the duplex d-(CCAAAAATTTCC)^.d-(GGTTTTTAAAGG) containing a (dA)₅ tract using two-dimensional ¹H NMR spectroscopy."Int. J. Biological Macromolecules 14, 57-63 (1992).

M. Akke, T. Drakenberg and W.J. Chazin."Three-dimensional solution structure of porcine calbindin D_9k."Biochemistry 31, 1011-1020 (1992).

W.J. Chazin, M. Rance, A. Chollet and W. Leupin."Comparative NMR analysis of the decadeoxynucleotide d-(GCATTAATGC)₂ and an analogue containing 2-aminoadenine." Nuc. Acids Res. 19, 5507-5513 (1991).

W.J. Chazin."New NMR structure and structural methodology."Current Opinion in Biotechnology 2, 520-525 (1991).

M. Akke, S. Forsén and W.J. Chazin."Molecular basis for cooperativity in Ca²⁺-binding to calbindin D_9k: ¹H NMR studies of (Cd²⁺)₁-bovine calbindin D_9k."J. Mol. Biol. 220, 173-189 (1991).

S.-M. Chen, F.L. Heffron, W. Leupin and W.J. Chazin."Two-dimensional ¹H NMR studies of synthetic immobile Holliday junctions."Biochemistry 30, 766-771 (1991).

W.J. Chazin."The time dependence and efficiency of excitation of three-quantum coherence in proton NMR spectroscopy of proteins."J. Magn. Reson. 91, 517-526 (1991).

N.J. Skelton, J. Kördel, S. Forsén and W.J. Chazin."Comparative structural analysis of the calcium free and bound states of the calcium regulatory protein calbindin D_9k."J. Mol. Biol. 213, 593-598 (1990).

N.J. Skelton, S. Forsén and W.J. Chazin."¹H NMR resonance assignments, secondary structure and global fold of apo bovine calbindin D_9k."Biochemistry 29, 5752-5761 (1990).

J. Kördel, S. Forsén, T. Drakenberg and W.J. Chazin."The rate and structural consequences of proline cis-trans isomerization in calbindin D_9k: NMR studies of the minor (cis Pro43) isoform and the Pro43->Gly mutant." Biochemistry 29, 4400-4409 (1990).

J. Cavanagh, W.J. Chazin and M. Rance."The time dependence of coherence transfer in homonuclear isotropic mixing experiments."J. Magn. Reson. 87, 110-131 (1990).

W.J. Chazin, J. Kördel, E. Thulin, T. Hofmann, T. Drakenberg and S. Forsén."Identification of an iso-aspartyl linkage formed upon deamidation of bovine calbindin D_9k and structural characterization by 2D ¹H NMR."Biochemistry 28, 8646-8653 (1989).

J. Kördel, S. Forsén and W.J. Chazin."¹H sequential resonance NMR assignments, secondary structure and global fold of the major trans Pro43 form of bovine calbindin D_9k."Biochemistry 28, 7065-7074 (1989).

M. Rance, W.J. Chazin, C. Dalvit and P.E. Wright."Multiple quantum NMR."Meth. Enzym 176A, 114-134 (1989).

T. Drakenberg, T. Hofmann and W.J. Chazin."¹H NMR studies of porcine calbindin D_9k in solution: Sequential resonance assignments, secondary structure and global fold." Biochemistry 28, 5946-5954 (1989).

W.J. Chazin, J. Kördel, T. Drakenberg, E. Thulin, P. Brodin, T. Grundström, and S. Forsén."Proline isomerism leads to multiple folded conformations of calbindin D_9k: Direct evidence by 2D ¹H NMR."Proc. Natl. Acad. Sci. USA 86, 2195-2198 (1989).