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Chazin Lab Chazin Lab Vanderbilt University

Refereed Publications

177. H.S. Hwang. F.R. Nitu, Y. Yang, K. Walweel, L. Pereira, C.N. Johnson, M. Faggioni, W.J. Chazin, D.R. Laver, A. George Jr., R.L. Cornea, D.M. Bers, and B.C. Knollmann.  "Divergent Regulation of RyR2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants."  Circulation Res. X, in press (2014).

176. Vaithiyalingam S, Arnett DR, Aggarwal A, Eichman BF, Fanning E, Chazin WJ.  "Insights into Eukaryotic Primer Synthesis from Structures of the p48 Subunit of Human DNA Primase."  J. Mol. Biol. 426, 558-569 (2014).

175. A.O. Frank, M.D. Feldkamp, J.P. Kennedy, A.G. Waterson, N.F. Pelz, J.D. Patrone, B. Vangamudi, D. Camper, O.W. Rossanese, W.J. Chazin and S.W. Fesik.  "Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions Using a Fragment Linking Approach."  J. Med. Chem. 56, 9242-9250 (2013).

174. M. Stork, J. Grijpstra, M.P. Bos, C. Mañas-Torres, N. Devos, C. Tans, J.T. Poolman, W.J. Chazin and J. Tommassen.  "Zinc Piracy as a Bacterial Mechanism for Evasion of Nutritional Immunity."  Plos Pathogens 9, e1003733 (2013).

173. S.M. Shell, E.K. Hawkins, M-S. Tsai, A.S. Hlaing, Carmelo J. Rizzo and Walter J. Chazin.  "Xeroderma pigmentosum complementation group C protein (XPC) serves as a general sensor of damaged DNA".  DNA Repair 12, 947-953 (2013).

172. M.D. Feldkamp, A.O. Frank, J.P. Kennedy, J.D. Patrone, B. Vangamudi, A.G. Waterson, S.W. Fesik and W.J. Chazin. "Surface reengineering of RPA70N enables co-crystallization with an inhibitor of the RPA interaction motif of ATRIP". Biochemistry 52, 6515-6524 (2013).

171. C.E. Wells, S. Bhaskara, K.R. Stengel, Y. Zhao, B.M. Sirbu, B. Chagot, D. Cortez, D. Khabele, W. Chazin, A. Cooper, V. Jacques J. Rusche, C. Eischen, L.Y. McGirt and S.W. Hiebert. "Inhibition of Histone Deacetylase 3 Causes Replication Stress in Cutaneous T Cell Lymphoma." Plos One 8, e68915 (2013).

170. T.E. Kehl-Fie, Y. Zhang, J.L. Moore, A. Farrand, M.I. Hood, S. Rathi, W.J. Chazin, R.M. Caprioli and E.P. Skaar.  "MntABC and MntH contribute to systemic Staphylococcus aureus infection by competing with calprotectin for nutrient manganes."  Infection and Immunity 81, 3395-3405 (2013).

169. D. Xu, J.H. Young, J.M. Krahn, D. Song, K.D. Corbett, W.J. Chazin, L.C. Pedersen, and J.D. Esko. "Stable RAGE-Heparan Sulfate Complexes Are Essential for Signal Transduction." ACS  Chem. Biol. X, (2013).

168. J.D. Patrone, J.P. Kennedy, A.O. Frank, M.D. Feldkamp, B. Vangamudi, N.F. Pelz, O.W. Rossanese, A.G. Waterson, W.J. Chazin and S.W. Fesik.  "Fragment-based Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A." ACS Med. Chem. Lett. 4, 601–605 (2013).

167. S.E. Soss, R.E. Klevit and W.J. Chazin.  "Activation of UbcH5c~Ub is the result of a shift in inter-domain motions of the conjugate when bound to the U-box E3 ligase E4B".  Biochemistry 52, 2991-2999 (2013).

166. S.M. Damo, T.E. Kehl-Fie, N. Sugitani, M.E. Holt, S. Rathi, W.J. Murphy, Y. Zhang, C. Betz, L. Hench, G. Fritz, E.P. Skaar and W.J. Chazin.  "Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens".  Proc. Natl. Acad. Sci., USA 110, 3841-3846 (2013).

165. L. Crotti, C.N. Johnson, E. Graf, G.M. De Ferrari, B.F. Cuneo, M. Ovadia, J. Papagiannis, M.D. Feldkamp, S.G. Rathi, J.D. Kunic, M. Pedrazzini, T. Wieland, P. Lichtner, B.-M. Beckmann, T. Clark, C. Shaffer, D.W. Benson, S. Kääb, T. Meitinger, T.M. Strom, W.J. Chazin, P.J. Schwartz, and A.L. George, Jr. "Calmodulin Mutations Provoke Recurrent Cardiac Arrest in Infants".  Circulation 127, 1009-1017 (2013).

164. C.A. Brosey, C. Yan, S.E. Tsutakawa, W.T. Heller, R.P. Rambo, J.A. Tainer, I. Ivanov* and W.J. Chazin*.  "A new structural framework for integrating replication protein A into DNA processing machinery."  Nucleic Acids Research 41, 2313-2327 (2013).

163. M.I. Hood, B.L. Mortensen, J.L. Moore, Y. Zhang, T.E. Kehl-Fie, N. Sugitani, W.J. Chazin, R.M. Caprioli and E.P. Skaar.  "Identification of an Acinetobacter baumannii zinc acquisition system that facilitates resistance to calprotectin-mediated zinc sequestration."  PLOS Pathogens 8, e1003068 (2012).

162. V. Rai, F. Touré, S. Chitayat, R. Pei, F. Song, Q. Li, R. Rosario, J. Garcia, Z. Zhu, R. Ramasamy, W.J. Chazin and A.M. Schmidt.  "Lysophosphatidic acid mediates vascular signaling and tumorigenesis via an immunoglobulin superfamily receptor." J. Exptl. Med. 209, 2339-2350 (2012).

161. J. Liu, S. Jellbauer, A. Poe, V. Ton, M. Pesciaroli, T. Kehl-Fie, N.A. Restrepo, M. Hosking, R.A. Edwards, A. Battistoni, P. Pasquali, T.E. Lane, W.J. Chazin, T. Vogl, J. Roth, E.P. Skaar and M. Raffatellu. "Zinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut." Cell Host and Microbe 11, 227-239 (2012).

160. J.N. Pruneda, P.J. Littlefield, S.E. Soss, K.A. Nordquist, W.J. Chazin, P.S. Brzovic and R.E. Klevit.  "Conformational activation of E2~Ubiquitin conjugates by RING-type E3 ligases.  Mol. Cell 47, 933-942 (2012).

159. G.D. Guler, H. Liu, S. Vaithiyalingam, D.R.Arnett, E. Kremmer, W.J. Chazin and E. Fanning. "Human DNA Helicase B (HDHB) Binds to Replication Protein A and Facilitates Cellular Recovery from Replication Stress." J. Biol. Chem. 287, 6469-6481 (2012).

158. E.M. Souza-Fagundes, A.O. Frank, M.D. Feldkamp, D.C. Dorset, W.J. Chazin, O.W. Rossanese, E.T. Olejniczak and S.W. Fesik. "A High-Throughput Fluorescence Polarization Assay for the 70N Domain of Replication Protein A." Analytical Biochem. 421, 742-749 (2012).

157. C.K. Williams, S. Vaithiyalingam, M. Hammel, J. Pipas and W.J. Chazin. "Binding to Retinoblastoma pocket domain does not alter the inter-domain flexibility of the J domain of SV40 large T antigen." Arch. Biochem. Biophys. 518, 111-118 (2012).

156. Y. Liu, S. Vaithiyalingam, Q. Shi, W.J. Chazin and S. Zinkel. "BID binds to Replication protein A and stimulates ATR function following replicative stress." Mol. Cell Biol. 31, 4298-4309 (2011).

155. T.E. Kehl-Fie, S. Chitayat, M.I. Hood, S. Damo, N. Restrepo, C. Garcia, K.A. Munro, W.J. Chazin* and E.P. Skaar*. "Nutritional metal sequestration by calprotectin enhances neutrophil killing of Staphylococcus aureus through inhibition of superoxide defense." Cell Host and Microbe 10, 158-164 (2011).

154. S.E. Soss, Y. Yue, S. Dhe-Paganon, and W.J. Chazin. "E2 selectivity and the requirements for function of the E3 ubiquitin ligase CHIP." J. Biol. Chem. 286, 21277-21286 (2011).

153. B. Chagot and W.J. Chazin. "Solution NMR Structure of apo-calmodulin in complex with the IQ motif of Human Cardiac Sodium Channel NaV1.5." J. Mol. Biol. 406, 106-119 (2011).

152. M. Koch, S. Chitayat, B.M. Dattilo, A. Schiefner, J. Dietz, W.J. Chazin*, and G. Fritz*. "Structural basis for ligand recognition and activation of RAGE." Structure 18, 1342-1352 (2010).

151. P.D. Robertson, B. Chagot, W.J. Chazin*, and B.F. Eichman*. "Solution NMR Structure of the C-terminal DNA Binding Domain of Mcm10 reveals a conserved MCM motif." J. Biol. Chem. 285, 22942-22949 (2010).

150. S. Vaithiyalingam, E.M. Warren, B.F. Eichman*, and W.J. Chazin*. "Insights into eukaryotic DNA priming from the structure and functional interactions of the 4Fe-4S cluster domain of human DNA primase." Proc. Natl. Acad. Sci., USA 107, 13684-13689 (2010).

149. H. Huang, B.E. Weiner, H. Zhang, B.E. Fuller, Y. Gao, B.M. Wile, K. Zhao, D.R. Arnett, W.J. Chazin*, and E. Fanning*. "Structure of a DNA polymerase \u03b1-primase domain that docks on the SV40 helicase and activates the viral primosome." J. Biol. Chem. 285, 17112-17122 (2010).

148. C.W. Vander Kooi, L. Ren, P. Xu, M.D. Ohi, K.L. Gould, and W.J. Chazin. "The Prp19 WD40 Domain Contains a Conserved Protein Interaction Region Essential for its Function." Structure 18, 584-593 (2010).

147. D.I. Pretto, S. Tsutakawa, C.A. Brosey, A. Castillo, M.-E. Chagot, J.A. Smith, J.A. Tainer, and W.J. Chazin. "Structural dynamics and ssDNA binding activity of the three N-terminal domains of the large subunit of RPA from small angle X-ray scattering." Biochemistry 49, 2880-2889 (2010).

146. Y.N. Dimitrova, J. Li, Y.-T. Lee, J. Rios-Esteves, D.B. Friedman, H.-J. Choi, W.I. Weis, C.-Y. Wang, and W.J. Chazin. "Direct ubiquitination of \u03b2-catenin by Siah-1 and regulation by the exchange factor TBL1." J. Biol. Chem. 285, 13507-13516 (2010).

145. J.L. McConnell, G.R. Watkins, S.E. Soss, H.S. Franz, L.R. McCorvey, B.W. Spiller, W.J. Chazin, and B.E. Wadzinski. "Alpha4 is a Ubiquitin-Binding Protein that Regulates PP2A Ubiquitination." Biochemistry 49, 1713-1718 (2010).

144. K.A. Nordquist, Y.N. Dimitrova, P.S. Brzovic, W.B. Ridenour, K.A. Munro, S.E. Soss, R.M. Caprioli, R.E. Klevit, and W.J. Chazin. "Structural and functional characterization of the Monomeric U-box domain from E4B U-box." Biochemistry 49, 347-355 (2010).

143. S. Ghavami, M. Eshragi, S.R Ande, W.J. Chazin, T. Klonisch, A.J. Halayko, C. Kerkhoff, and M. Los. "S100A8/A9 simultaneously induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes and it involves BNIP3." Cell Research 20, 314-331 (2010).

142. G. Sowd, H. Wang, D. Pretto, W.J. Chazin, and P.L. Opresko. "RPA Stimulates the Werner Syndrome Protein Branch Migration Activity." J. Biol. Chem. 284, 34682-34691 (2009).

141. S.-B. Qian, L. Waldron, N. Choudhary, R.E. Klevit, W.J. Chazin, and C. Patterson. "Engineering ubiquitin ligases reveals conformational flexibility required for ubiquitin transfer." J. Biol. Chem. 284, 26797-26802 (2009).

140. E.M. Warren, H. Huang, E. Fanning, W.J. Chazin, and B.F. Eichman. "Physical Interactions Between Mcm10, DNA and DNA Polymerase." J. Biol. Chem. 284, 24662-24672 (2009).

139. S.M. Shell, Z. Li, N. Shkriabai, M. Kvaratskhelia, C. Brosey, M.A. Serrano, W.J. Chazin, P.R. Musich, and Y. Zou. "Checkpoint Kinase ATR Promotes Nucleotide Excision Repair of UV-induced DNA Damage via Physical Interaction with XPA." J. Biol. Chem. 284, 24213-24222 (2009).

138. R.N. Pruitt, B. Chagot, M. Cover, W.J. Chazin, B. Spiller, and D.B. Lacy. "Structure-Function Analysis of Inositol Hexakisphosphate-induced Autoprocessing in Clostridium difficile Toxin A." J. Biol. Chem. 284, 21934-21940 (2009).

137. F. Potet, B. Chagot, M. Anghelescu, S.Z. Stepanovic, W.J. Chazin, and J.R. Balser. "Functional interactions between distinct cytoplasmic domains and calmodulin revealed through the effects of lidocaine on NaV1.5 inactivation gating." J. Biol. Chem. 284, 8846-8854 (2009).

136. C.A. Brosey, M.-E. Chagot, M. Ehrhardt, D.I. Pretto, B.E. Weiner, and W.J. Chazin. "NMR Analysis of the Architecture and Functional Remodeling of a Modular Multi-Domain Protein, RPA." J. Amer. Chem. Soc. 131, 6346-6347 (2009).

135. B. Chagot, F. Potet, J.R. Balser, and W.J. Chazin. "Solution NMR Structure of the C-terminal EF-hand domain of human cardiac sodium channel NaV1.5." J. Biol. Chem. 284, 6436-6445 (2009).

134. A.A. Zalia, K.J. Sappington, K. Nisapakultorn, W.J. Chazin, E.A. Dietrich, K.F. Ross, and M.C. Herzberg. "Subversion of antimicrobial calprotectin (S100A8/S100A9 complex) in the cytoplasm of TR146 epithelial cells after invasion by Listeria moncytogenes." Mucosal Immunol. 2, 43-53 (2009).

133. X. Xu, S. Vaithiyalingam, G.G. Glick, D. A. Mordes, W. J. Chazin, and D. Cortez. "The basic cleft of RPA70N binds multiple checkpoint proteins including RAD9 to regulate ATR signaling." Mol. Cell Biol. 28, 7345-7353 (2008).

132. Y.-T. Lee, Y.N. Dimitrova, G. Schneider, W.B. Ridenour, S. Bhattacharya, S.E. Soss, R.M. Caprioli, A. Filipek and W.J. Chazin. "Structure of the S100A6 complex with a fragment from the C-terminal domain of Siah-1 interacting protein: A novel mode for S100 protein target recognition." Biochemistry 47, 10921-10932 (2008).

131. E.M. Warren, S. Vaithiyalingam, J. Haworth, B. Greer, J.A. Smith, A.-K. Bielinsky, W.J. Chazin, and B.F. Eichman. "Structural Basis for DNA Binding by Replication Initiator Mcm10." Structure 16, 1892-1901 (2008).

130. S. Ghavami, I. Rashedi, B.M. Dattilo, M. Eshraghi, W.J. Chazin, M. Hashemi, S. Wesselborg, C. Kerkhoff, and M. Los. "S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway." J. Leukocyte Biol. 83, 1484-1492 (2008).

129. B.D. Corbin, E.H. Seeley, A. Raab, J. Feldman, M.R. Miller, V.J. Torres, K.L. Anderson, B.M. Datillo, P.M. Dunman, R. Gerads, R.M. Caprioli, W. Nacken, W.J. Chazin, and E.P. Skaar. "Metal chelation and inhibition of bacterial growth in tissue abscesses." Science 319, 962-965 (2008).

128. S. Ghavami, C. Kerkhoff, W.J. Chazin, K. Kadkhoda, W. Xiao, A. Zuse, M. Hashemi, M. Eshraghi, K. Schulze-Osthoff, T. Klonisch and M. Los. "S100A8/9 Induces Cell Death via a Novel, RAGE-independent Pathway that Involves Selective Release of Smac/DIABLO and Omi/HtrA2." BBA-Mol. Cell Res. 1783, 297-311 (2008).

127. B.E. Weiner, H. Huang, B.M. Dattilo, M.J. Nilges, E. Fanning, and W.J. Chazin. "An iron-sulfur cluster in the C-terminal domain of the p58 subunit of human DNA primase." J. Biol. Chem. 282, 33444-33451 (2007).

126. B.M. Dattilo, G. Fritz, E. Leclerc, C.W. Heizmann, C.W. Vander Kooi, and W.J. Chazin. "The Extracellular Region of the Receptor for Advanced Glycation Endproducts is Composed of Two Independent Structural Units." Biochemistry 46, 6957-6970 (2007).

125. H.L. Ball, M.R. Ehrhardt, D.A. Mordes, G.G. Glick, W.J. Chazin, and D. Cortez. "Function of a Conserved Checkpoint Recruitment Domain in ATRIP Proteins." Mol. Cell Biol. 27, 3367-3377 (2007).

124. M. Koch, S. Bhattacharya, T. Kehl, M. Gimona, M. Vasák, W. Chazin, C.W. Heizmann, P.M.H. Kroneck, and G. Fritz. "Implications of Zinc Binding to S100A2." BBA Mol. Cell Res. 1773,457-470 (2007).

123. X. Jiang, V. Klimovich, A.I. Arunkumar, E.B. Hysinger, Y. Wang, R.D. Ott, J. Ferguson, B. Weiner, W.J. Chazin* and E. Fanning*. "Structural mechanism of helicase-mediated RPA loading on DNA during activation of a simple pre-replication complex." EMBO J. 25, 5516-55126 (2006).

122. C.G. Bunick, M.R. Miller, B.E. Fuller, E. Fanning and W.J. Chazin. "Biochemical and Structural Domain-Analysis of XPC." Biochemistry 45, 14965-14979 (2006).

121. K. Sunahori, M. Yamamura, J. Yamana, K. Takasugi, M. Kawashima, H. Yamamoto, W.J. Chazin, Y. Nakatani, S. Yui, and H. Makino. "The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis." Arthritis Res. Ther. 8, R39 (12 pages) (2006).

120. V.N. Shah, T.L. Wingo, K.L. Weiss, C.K. Williams, J.R. Balser and W.J. Chazin. "Calcium-dependent regulation of the cardiac voltage-gated sodium channel hH1: Intrinsic and extrinsic sensors act through a common molecular switch." Proc. Natl. Acad. Sci., USA 103, 3592-3597 (2006).

119. E. Johnson, W.J. Chazin and M. Rance. "Effects of Calcium Binding on the Side-chain Methyl Dynamics of Calbindin D9k: A 2H NMR Relaxation Study." J. Mol. Biol. 357, 1237-1252 (2006).

118. V. Chandran, E.J. Stollar, K. Lindorff-Larsen, J.F. Harper, W.J. Chazin, C.M. Dobson, B.F. Luisi and J. Christodoulou. "Structure of the regulatory apparatus of a calcium-dependent protein kinase (CDPK): a novel mode of calmodulin-target recognition." J. Mol. Biol. 357, 400-410 (2006).

117. S.M. Meyn, C. Seda, M. Campbell, K.L. Weiss, H. Hu, B. Pastrana-Rios and W.J. Chazin. "The biochemical effect of Ser167 phosphorylation on chlamydomonas rheinhardti centrin." Biochem. Biophys. Res. Commun. 342, 342-348 (2006).

116. J.H. Sheehan, C.G. Bunick, H. Hu, P.A. Fagan and W.J. Chazin. "Structure of the N-terminal Calcium Sensor Domain of Centrin Reveals the Biochemical Basis for Domain-Specific Function." J. Biol. Chem. 281, 2876-2881 (2006).

115. C.W. Vander Kooi, M.D. Ohi, J.A. Rosenberg, M.L. Oldham, M.E. Newcomer, K.L. Gould, and W.J. Chazin. "The Prp19 U-box U-box Crystal Structure Suggests a Common Architecture for a Class of Oligomeric E3 Ubiquitin Ligases." Biochemistry 45, 121-130 (2006)

114. Y. Nakatani, M. Yamazaki, W.J. Chazin and S. Yui. "Regulation of S100A8/A9 (Calprotectin) Binding to Tumor Cells by Zinc Ion and its implication for apoptosis-inducing activity" Mediators of Inflammation 5, 280-92 (2005).

113. S. Bhattacharya, Y.-T. Lee, W. Michowski, B. Jastrzebska, A. Filipek, J. Kuznicki and W.J. Chazin. "The modular structure of SIP facilitates its role in stabilizing multi-protein assemblies." Biochemistry 44, 9462-9471 (2005).

112. A. Malmedal, C.W. Vander Kooi, N.C. Nielson and W.J. Chazin. "Calcium-modulated S100 protein-phospholipid interactions. An NMR study of calbindin D9k and DPC." Biochemistry 44, 6502-6512 (2005).

111. B.T. Vander Kooi, H. Onuma, J.K. Oeser, C.A. Svitek, S.R. Allen, C.W. Vander Kooi, W.J. Chazin and R.M. O\u2019Brien. "The Glucose-6-Phosphatase Catalytic Subunit Gene Promoter Contains Both Positive and Negative Glucocorticoid Response Elements." Molec. Endocrinol. 19, 3001-3022 (2005).

110. A.I. Arunkumar, V. Klimovich, X. Jiang, R.D. Ott, L. Mizoue, E. Fanning* and W.J. Chazin*. "Structural and functional insights into RPA32 C-terminal domain-mediated assembly of the simian virus 40 replisome." Nature Structural and Molecular Biology 12, 332-339 (2005).

109. M. Ortiz, Z. Sanoguet, H. Hu, W.J. Chazin, C. McMurray, J.L. Salisbury and B. Pastrana-Rios. "Dynamics of Hydrogen/Deuterium Exchange in Chlamydomonas Centrin." Biochemistry 44, 2409-2418 (2005).

108. M.D. Ohi, C.W. Vander Kooi, J.A. Rosenberg, L. Ren, J.P. Hirsch, W.J. Chazin, T. Walz, and K.L. Gould. "Prp19p tetramerization is required for pre-mRNA splicing." Mol. Cell Biol. 25, 451-460 (2005).

107. H. Hu, J.H. Sheehan and W.J. Chazin. "The Mode of Action of Centrin: Binding of Ca2+ and a Peptide Fragment of Kar1p to the C-terminal Domain." J. Biol. Chem. 279, 50895-50903 (2004).

106. H. Highfield-Nickols, V.N. Shah, W.J. Chazin, and L.E. Limbird. "Calmodulin interacts with the V2 vasopressin receptor: Elimination of binding to the C-terminus also eliminates AVP-stimulated elevation of intracellular calcium." J. Biol. Chem. 279, 46969-46980 (2004).

105. J. Christodoulou, A. Malmendal, J.F. Harper and W.J. Chazin. "Evidence for Differing Roles for Each Lobe of the Calmodulin-like Domain in a Calcium-dependent Protein Kinase." J. Biol. Chem. 279, 29092-29100 (2004).

104. C.G. Bunick, M.R. Nelson, S. Mangahas, M.J. Hunter, J.H. Sheehan, L.S. Mizoue, G.J. Bunick and W.J. Chazin. "Designing sequence to control function in an EF-hand Protein." J. Amer. Chem. Soc. 126, 5990-5998 (2004).

103. S. Bhattacharya, A.I. Arunkumar, S.L. Sullivan, M.-V. Botuyan, C.H. Arrowsmith and W.J. Chazin. "Letter to the Editor: 1H, 13C and 15N assignments of single-stranded DNA binding domains from the 70 kDa subunit of Human Replication Protein A." J. Biomol. NMR. 28, 195-196 (2004).

102. M.E. Stauffer and W.J. Chazin. "Physical Interaction between RPA and Rad51 is Essential for Efficient Initiation of Recombination." J. Biol. Chem. 279, 25638-25645 (2004).

101. Y.-T. Lee, J. Jacob, W. Michowski, M. Nowotny, J. Kuznicki and W.J. Chazin. "Human Sgt1 binds to HSP90 through its CS domain: CS domain is a general binding module for HSP90." J. Biol. Chem. 279, 16511-16517 (2004).

100. T.L. Wingo, V.N. Shah, M.E. Anderson, T.P. Lybrand, W.J. Chazin* and J.R. Balser*. "An EF-Hand in the sodium channel couples intracellular calcium to cardiac excitability." Nature Structural and Molecular Biology 11, 219-225 (2004).

99. S. Bhattacharya, E. Large, C.W. Heizmann, B. Hemmings and W.J. Chazin. "Structural mechanism of calcium dependent regulation of the NDR Kinase by S100B." Biochemistry 42, 14416-14426 (2003).

98. C. Bassarello, P. Cimino, G. Bifulco, D.L. Boger, J.A. Smith, W.J. Chazin, and L. Gomez-Paloma. "NMR Structure of the (+)-CPI-indole/d(GACTAATTGAC)-d(GTCAATTAGTC) Covalent Complex." Chem. Biochem. 4, 1188-1193 (2003).

97. A.I. Arunkumar, M.E. Stauffer, E. Bochkareva, A. Bochkarev, and W.J. Chazin . "Independent and coordinated functions of the Replication Protein A tandem high affinity ssDNA binding domains." J. Biol. Chem. 278, 41077-41082 (2003).

96. J.-H. Lee, C.-J. Park, A.I. Arunkumar, W.J. Chazin and B.-S. Choi "NMR study on the interaction between RPA and DNA decamer-containing cis-syn cyclobutane pyrimidine dimer in the presence of XPA: Implication for damage verification and strand-specific dual incision in nucleotide excision repair." Nucleic Acids Research 31, 4747-4754 (2003).

95. H. Hu and W.J. Chazin. "Unique Features in the C-terminal Domain Provide Caltractin with Target Specificity." J. Mol. Biol. 330, 473-484 (2003).

94. M.D. Ohi, C.W. Vander Kooi, J.A. Rosenberg, W.J. Chazin* and K. L. Gould*. "Structural Insights Into the U-box, A Domain Associated with Multi-Ubiquitination." Nature Structural Biol. 10, 250-255 (2003).

93. A. Malmendal, S. Halpain and W.J. Chazin. "Biophysical Characterization of Protected Domains in Microtubule-Associated Protein 2." Biochem. Biophys. Res. Commun. 301, 136-142 (2003).

92. S. Bhattacharya, M.V. Botuyan, F. Hsu, X. Shan, A.I. Arun Kumar, C.H. Arrowsmith, A.M. Edwards and W.J. Chazin. "Characterization of Backbone Dynamics Suggests a Model for Sequence Non-Specific Binding of ssDNA by Replication Protein A." Protein Science 11, 2316-2325 (2002).

91. S. Veeraraghavan, P.A. Fagan, H. Hu, V. Lee, J.F. Harper, B. Huang and W.J. Chazin. "Structural independence of the two EF-hand domains of caltractin." J. Biol. Chem. 277, 28564-28571 (2002).

90. J. Christodoulou, H. Hu, J. Chung, M. Rance, J.F. Harper and W.J. Chazin. "1H, 15N and 13C assignments of the regulatory domains of calcium-dependent protein kinase (CDPK)." J. Biomolec. NMR 23, 249-250 (2002).

89. L. Mäler, M. Sastry and W.J. Chazin. "Ca2+-induced structural changes in S100 proteins: High resolution solution structure of Ca2+\u2013bound calcyclin" J. Mol. Biol. 317, 279-290 (2002).

88. M.R. Nelson, E. Thulin, P.A. Fagan, S. Forsén and W.J. Chazin. "The EF-hand domain: a globally cooperative structural unit." Protein Science 11, 198-205 (2002).

87. S. Yui, Y. Nakatani, M.J. Hunter, W.J. Chazin and M. Yamazaki. "Implication of extracellular zinc exclusion by recombinant human calprotectin (MRP8 and MRP14) from target cells in its apoptosis-inducing activity." Mediators of Inflammation 11, 165-172 (2002).

86. A. Randazzo, C. Acklin, B.W. Shaefer, C.W. Heizmann and W.J. Chazin. "Structural insight into Zn2+-bound S100A2 from NMR and homology modeling." Biochem. Biophys. Res. Commun., 462-467 (2001).

85. M.V. Botuyan, G. Mer, G.S. Yi, C.M. Koth, D.A. Case, A.M. Edwards, *W.J. Chazin and *C.H. Arrowsmith. "Solution Structure of Yeast Elongin C in Complex with a VHL Peptide." J. Mol. Biol. 312, 177-186 (2001).

84. G. Mer, A. Bochkarev, R. Gupta, E. Bochkarev, L.D. Frappier, C.J. Ingles, A.M. Edwards and W.J. Chazin. "Structural Basis for the Recognition of DNA Repair Proteins UNG2, XPA, and RAD52 by Replication Factor RPA." Cell 103, 449-456 (2000).

83. M. Nowotny, S. Bhattacharya, A. Filipek, A.M. Krezel, W.J. Chazin, and J. Kuznicki. "Characterization of the interaction of calcyclin (S100A6) and calcyclin-binding protein." J. Biol. Chem. 275, 31178-31182 (2000).

82. P.G. Sohnle, M.J. Hunter, B. Hahn, and W.J. Chazin. "Zinc-Reversible Antimicrobial Activity Recombinant Calprotectin (Migration Inhibitory Factor\u2014Related Proteins 8 and 14)." J. Infectious Diseases 182, 1272-1275 (2000).

81. G. Mer, A.M. Edwards and W.J. Chazin. "1H, 13C, and 15N assignments of the C-terminal protein interaction region of the 32 kDa subunit of replication protein A." J. Biomolec. NMR 17, 179-180 (2000).

80. V. Vitart, J. Christodoulou, J.-F. Huang, W. J. Chazin and J. F. Harper. "Intramolecular Activation of a Ca2+-Dependent Protein Kinase Is Disrupted by Insertions in the Tether That Connects the Calmodulin-like Domain to the Kinase." Biochemistry 39, 4004-4011 (2000).

79. J.A. Smith, G. Bifulco, D.A. Case, D.L. Boger, L. Gomez-Paloma and W.J. Chazin. "The structural basis for in-situ activation of DNA alkylation by duocarmycin SA." J. Mol. Biol. 300, 1195-1204 (2000).

78. C.M. Koth, M.V. Botuyan, R. J. Moreland, D. Jansma, J.W. Conaway, R.C. Conaway, W.J. Chazin, J.D. Friesen, C.H. Arrowsmith and A.M. Edwards. "Elongins from Saccharomyces cerevisiae." J. Biol. Chem. 275,. 11174-11180 (2000).

77. L. Mäler, J Blankenship, M. Rance and W.J. Chazin. "Site-site Communication in the EF-hand Ca2+-binding protein calbindin D9k." Nature Structural Biol. 7, 245-250 (2000).

76. M.V. Botuyan, C.M. Koth, G. Mer, A. Chakrabatartty, J.W. Conaway, R.C. Conaway, A.M. Edwards, *C.H. Arrowsmith and *W.J. Chazin. "Binding of Elongin A or a von Hippel-Lindau Peptide Stabilizes the Structure of Yeast Elongin C." Proc. Natl. Acad. Sci., USA 96, 9033-9038 (1999).

75. J. Schnell, R.R. Ketchem, D.L. Boger and W.J. Chazin. "High resolution solution structure of a DNA duplex alkylated by the indole derivative of the antitumor agent duocarmycin SA." J. Amer. Chem. Soc. 121, 5645-5652 (1999).

74. T.D. Veenstra and W.J. Chazin. "Determination of the metal-binding cooperativity of wild-type and mutant calbindin D9k by electrospray ionization mass spectrometry." Rapid Commun. Mass Spectrom. 13, 548-555 (1999).

73. L. Mäler, B.C.M. Potts and W.J. Chazin. "High resolution solution structure of apo calcyclin and structural variations in the S100 family of calcium-binding proteins." J. Biomol. NMR 13, 233-247 (1999).

72. S.K. Wilcox, C.D. Putnam, M. Sastry, J. Blankenship, W.J. Chazin, D.E. McRee, and D.B. Goodin. "Rational Design of a Functional Metalloenzyme: Introduction of a Site for Manganese Binding and Oxidation into a Heme Peroxidase." Biochemistry 37, 16853-16862 (1998).

71. G. Bifulco, A. Galeone, K.C. Nicolaou, W.J. Chazin and L. Gomez-Paloma. "Solution structure of the complex between the head-to-tail dimer of calcicheamicin oligosaccharide and a DNA duplex containing d(ACCT) and d(TCCT) high affinity binding sites." J. Amer. Chem. Soc. 120, 7183-7191 (1998).

70. M.J. Hunter and W.J. Chazin. "High level expression and dimer characterization of the S100 EF-hand proteins, migration inhibitory factor-related proteins 8 and 14." J. Biol. Chem. 273, 12427-12435 (1998).

69. B.B. Kragelund, M. Jönnson, G. Bifulco, W.J. Chazin, H. Nilsson, B.E. Finn and S. Linse. "Hydrophobic core substitutions in calbindin D9k. Effects on Ca2+-binding and dissociation." Biochemistry 37,8926-8937 (1998).

68. M. Sastry, R. R. Ketchem, O. Crescenzi, C. Weber, M.J. Lubienski, H. Hidaka and W.J. Chazin. "The three-dimensional structure of Ca2+-bound calcyclin: Implications for Ca2+-signal transduction by S100 proteins." Structure 6, 223-231 (1998).

67. G. Mer and W.J. Chazin. "Enzymatic synthesis of region-specific isotope-labeled DNA oligomers for NMR analysis." J. Amer. Chem. Soc. 120, 607-608 (1998).

66. M. Nelson and W.J. Chazin. "An interaction-based analysis of calcium-induced conformational changes in Ca2+ sensor proteins." Protein Science 7, 270-282 (1998).

65. B.C. Potts and W.J. Chazin. "Chemical shift homology in proteins." J. Biomolec. NMR 11, 45-57 (1998).

64. S.M. Miick, R.S. Fee, *D.P. Millar and *W.J. Chazin. "Crossover isomerization is the primary sequence-dependent property of the Holliday junction." Proc. Natl. Acad. Sci. USA 94, 9080-9084 (1997).

63. J. Kördel, D.A. Pearlman and W.J. Chazin. "Protein solution structure calculations in solution: solvated molecular dynamics refinement of calbindin D9k." J. Biomolec. NMR 10, 231-243 (1997).

62. P.S. Eis, J. Smith, J. Rydzewski, D.A. Case, D.L. Boger and W.J. Chazin. "High resolution solution structure of a DNA duplex alkylated by the antitumor agent duocarmycin SA." J. Mol. Biol. 272, 237-252 (1997).

61. L.K. Lee, M. Rance, W.J. Chazin, and A.G. Palmer III. "Rotational diffusion anisotropy of proteins from simultaneous analysis of 15N and 13Ca nuclear spin relaxation." J. Biomolec. NMR 9, 287-298 (1997).

60. J. Smith, L.G. Paloma, D.A. Case and W.J. Chazin. "Molecular dynamics docking driven by NMR derived restraints to determine the structure of the calicheamicin oligosaccharide domain complexed to duplex DNA." Magn. Reson. Chem. 34:S, 147-155 (1996).

59. G. Bifulco, A. Galeone, L.Gomez-Paloma, K.C. Nicoloau and W.J. Chazin. "Solution structure of the head-to-head dimer of the calicheamicin oligosaccharide domain and d(CGTAGGATATCCTACG)2." J. Amer. Chem. Soc. 118, 8817-8824 (1996).

58. B.C. Potts, G. Carlström, K. Okazaki, H. Hidaka and W.J. Chazin. "1H NMR assignments of apo calcyclin and comparative structural analysis with calbindin D9k and S100." Protein Science 5, 2162-2174 (1996).

57. G. Carlström and W.J. Chazin. "Sequence dependence and direct measurement of crossover isomer distribution in model Holliday junction using NMR spectroscopy." Biochemistry 35, 3534-3544 (1996).

56. J. Rydzewski, W. Leupin and W.J. Chazin. "The width of the minor groove affects the binding of the bisquaternary heterocycle SN-6999 to duplex DNA." Nucl. Acids Res. 24, 1287-1293 (1996).

55. B.C. Potts, J. Smith, M. Akke, T.J. Macke, K. Okazaki, H. Hidaka, D.A. Case and W.J. Chazin. "The structure of calcyclin reveals a novel homodimeric fold for S100 Ca2+-binding proteins." Nature Structural Biology 2, 790-796 (1995).

54. M. Akke, S. Forsén and W.J. Chazin. "Solution structure of (Cd2+)1 calbindin D9k reveals details of the stepwise structural changes along the apo\u2192(Ca2+)1II\u2192(Ca2+)2II,I binding pathway." J. Mol. Biol. 252, 102-121 (1995). ;&q&uto&&< "

53. B.T. Wimberly, E. Thulin, and W.J. Chazin. "Characterization of the N-terminal half-saturated state of calbindin D9k: NMR studies of the N56A mutant." Protein Science 4, 1045-1055 (1995).

52. S. Linse and W.J. Chazin. "Quantitative measurements of the cooperativity in an EF-hand protein with sequential calcium binding." Protein Science 4, 1038-1044 (1995).

51. N.J. Skelton, J. Kördel and W.J. Chazin. "Determination of the solution structure of apo calbindin D9k by NMR spectroscopy." J. Mol. Biol. 249, 441-462 (1995).

49. S.-M. Chen and W.J. Chazin. "Two-dimensional 1H NMR studies of immobile holiday junctions: Nonlabile proton assigments and identification of crossover isomers." Biochemistry 33, 11453-11459 (1994).

50. S. Linse, B. Jönsson and W.J. Chazin. "The effect of protein concentration on ion binding." Proc. Natl. Acad. Sci. USA 92, 4748-4752 (1995).

48. C. Weber, V.D. Lee, W.J. Chazin and B. Huang. "High level expression in Escherichia coli and characterization of the EF-hand calcium-binding protein caltractin." J. Biol. Chem. 269, 15795-15802 (1994).

47. L.G. Paloma, J. Smith, W.J. Chazin and K.C. Nicoloau. "Interaction of calicheamicin and DNA: Role of the oligosaccharide domain and identification of multiple binding modes." J. Amer. Chem. Soc. 116, 3697-3708 (1994).

46. N.J. Skelton, J. Kördel, M. Akke, S. Forsén and W.J. Chazin. "Signal transduction versus buffering activity in Ca2+ binding proteins." Nature Structural Biology 1, 239-245 (1994).

45. M. Akke, S. Forsén and W.J. Chazin. "15N NMR Assignments of (Cd2+)2-calbindin D9k and comparison with (Ca2+)2-calbindin D9k. Cadmium as a substitute for calcium in calcium-binding proteins." Magn. Reson. Chem. 31(S), 128-132 (1993).

44. M. Akke, N.J. Skelton, J. Kördel, A.G. Palmer, III and W.J. Chazin. "Effects of ion binding on the backbone dynamics of calbindin D9k determined by 15N NMR relaxation." Biochemistry 32, 9832-9844 (1993).

42. G. Carlström and W.J. Chazin. "Two-dimensional 1H nuclear magnetic resonance studies of the half-saturated (Ca2+)1 state of calbindin D9k: further implications for the molecular basis of cooperative Ca2+ binding." J. Mol. Biol. 227, 415-430 (1993).

43. J. Kördel, N.J. Skelton, M. Akke and W.J. Chazin. "High-resolution structure of calcium-loaded calbindin D9k." J. Mol. Biol. 231, 711-734 (1993).

41. N.J. Skelton, A.G. Palmer, III, M. Akke and W.J. Chazin. "Practical aspects of 15N NMR relaxation measurements." J. Magn. Reson. 102B, 253-264 (1993).

40. S.-M. Chen, F.L. Heffron and W.J. Chazin. "Two-dimensional 1H NMR studies of 32-base-pair synthetic immobile holliday junctions: Complete assignments of the labile protons and identification of the base-pairing scheme." Biochemistry 32, 319-326 (1993).

39. N.J. Skelton, J. Kördel, M. Akke and W.J. Chazin. "Nuclear magnetic resonance studies of the internal dynamics in apo, (Cd2+)1, and (Ca2+)2 calbindin D9k." J. Mol. Biol. 227, 1100-1117 (1992).

38. J. Kördel, N.J. Skelton, A.G. Palmer, III and W.J. Chazin. "Backbone dynamics of calcium-loaded bovine calbindin D9k determined by 15N NMR relaxation." Biochemistry 31, 4856-4866 (1992).

37. S.-M. Chen, M. Rance, W. Leupin and W.J. Chazin. "Two-dimensional NMR studies of d-(GGTTAATGCGGT).d-(ACCGCATTAACC) complexed with the minor groove binding drug SN-6999." Biochemistry 31, 4406-4413 (1992).

36. N.J. Skelton, M. Akke, J. Kördel, E. Thulin, S. Forsén and W.J. Chazin. "15N assignments and chemical shift analysis of uniformly labeled calbindin D9k in the apo, (Cd2+)1, and (Ca2+)2 states." FEBS Lett. 303, 136-140 (1992).

35. A.G. Palmer, III, N.J. Skelton, W.J. Chazin, P.E. Wright and M. Rance. "Suppression of the effects of cross-correlation between dipolar and anisotropic chemical shift relaxation mechanisms in the measurement of spin-spin relaxation rates." Mol. Phys. 75, 699-711 (1992).

34. S.-M. Chen, W. Leupin and W.J. Chazin. "Conformational studies of the duplex d-(CCAAAAATTTCC).d-(GGTTTTTAAAGG) containing a (dA)5 tract using two-dimensional 1H NMR spectroscopy." Int. J. Biological Macromolecules 14, 57-63 (1992).

33. M. Akke, T. Drakenberg and W.J. Chazin. "Three-dimensional solution structure of porcine calbindin D9k." Biochemistry 31, 1011-1020 (1992).

32. W.J. Chazin, M. Rance, A. Chollet and W. Leupin. "Comparative NMR analysis of the decadeoxynucleotide d-(GCATTAATGC)2 and an analogue containing 2-aminoadenine." Nuc. Acids Res. 19, 5507-5513 (1991).

31. J.M. Moore, C. Lepre, G.P. Gippert, W.J. Chazin, D.A. Case and P.E. Wright. "High-resolution solution structure of reduced french bean plastocyanin and comparison with the crystal structure of poplar plastocyanin." J. Mol. Biol. 221, 533-555 (1991).

30. M. Akke, S. Forsén and W.J. Chazin. "Molecular basis for cooperativity in Ca2+-binding to calbindin D9k: 1H NMR studies of (Cd2+)1-bovine calbindin D9k." J. Mol. Biol. 220, 173-189 (1991).

29. S.-M. Chen, F.L. Heffron, W. Leupin and W.J. Chazin. "Two-dimensional 1H NMR studies of synthetic immobile Holliday junctions." Biochemistry 30, 766-771 (1991).

28. W.J. Chazin. "The time dependence and efficiency of excitation of three-quantum coherence in proton NMR spectroscopy of proteins." J. Magn. Reson. 91, 517-526 (1991).

27. N.J. Skelton, J. Kördel, S. Forsén and W.J. Chazin. "Comparative structural analysis of the calcium free and bound states of the calcium regulatory protein calbindin D9k." J. Mol. Biol. 213, 593-598 (1990).

26. N.J. Skelton, S. Forsén and W.J. Chazin. "1H NMR resonance assignments, secondary structure and global fold of apo bovine calbindin D9k." Biochemistry 29, 5752-5761 (1990).

25. J. Kördel, S. Forsén, T. Drakenberg and W.J. Chazin. "The rate and structural consequences of proline cis-trans isomerization in calbindin D9k: NMR studies of the minor (cis Pro43) isoform and the Pro43\u2192Gly mutant ." Biochemistry 29, 4400-4 " &409 (1990).

24. J. Cavanagh, W.J. Chazin and M. Rance. "The time dependence of coherence transfer in homonuclear isotropic mixing experiments." J. Magn. Reson. 87, 110-131 (1990).

23. W.J. Chazin*, J. Kördel, E. Thulin, T. Hofmann, T. Drakenberg and S. Forsén*. "Identification of an iso-aspartyl linkage formed upon deamidation of bovine calbindin D9k and structural characterization by 2D 1H NMR." Biochemistry 28, 8646-8653 (1989).

22. J. Kördel, S. Forsén and W.J. Chazin. "1H sequential resonance NMR assignments, secondary structure and global fold of the major trans Pro43 form of bovine calbindin D9k." Biochemistry 28, 7065-7074 (1989).

21. T. Drakenberg, T. Hofmann and W.J. Chazin. "1H NMR studies of porcine calbindin D9k in solution: Sequential resonance assignments, secondary structure and global fold." Biochemistry 28, 5946-5954 (1989).

20. W.J. Chazin, J. Kördel, T. Drakenberg, E. Thulin, P. Brodin, T. Grundström, and S. Forsén. "Proline isomerism leads to multiple folded conformations of calbindin D9k: Direct evidence by 2D 1H NMR." Proc. Natl. Acad. Sci. USA 86, 2195-2198 (1989).

19. B. Celda, H. Widmer, W. Leupin, W.J. Chazin, W.A. Denny and K. Wüthrich. "Studies of the conformation of d(AAAAATTTTT)2 using constraints from nuclear Overhauser effects and from quantitative analysis of the cross peak fine structures in two dimensional 1H NMR spectra." Biochemistry 28, 1462-1470 (1989).

18. W.J. Chazin, T.E. Hugli and P.E. Wright. "1H NMR studies of human C3a anaphylatoxin in solution: Sequential resonance assignments, secondary structure and global fold." Biochemistry 27, 9139-9148 (1988).

17. J.M. Moore, W.J. Chazin, R. Rowls and P.E. Wright. "1H NMR studies of plastocyanin from Scenedesmus obliquus: complete sequence-specific assignment, secondary structure analysis and global fold." Biochemistry 27, 7806-7816 (1988).

15. W.J. Chazin and P.E. Wright. "Complete assignment of the 1H NMR spectrum of French bean plastocyanin: Sequential resonance assignments, analysis of secondary structure and determination of global fold in solution.&quto; J. Mol. Biol. 202, 623-636 (1988).

16. J.M. Moore, D.A. Case, W.J. Chazin, G. Gippert, T.F. Havel, R. Rowls and P.E. Wright. "Solution structure of plastocyanin from the green alga, Scenedesmus obliquus." Science 240, 314-317 (1988).

14. W.J. Chazin, M. Rance and P.E. Wright. "Complete assignment of the 1H NMR spectrum of French bean plastocyanin: Application of an integrated approach to spin system identification in proteins." J. Mol. Biol. 202, 603-622 (1988).

13. J. Siekmann, H.R. Wenzel, W. Schröder, H. Schutt, E. Truscheit, A. Arens, E. Rauenbusch, W.J. Chazin, K. Wüthrich and H. Tschesche. "Pyroglutamyl-aprotinin, a new aprotinin homologue from bovine lungs - isolation, properties, sequence analysis and characterization using 1H NMR in solution." Biol. Chem. Hoppe-Seyler, 368, 1589-1596 (1987).

12. W.J. Chazin, M. Rance and P.E. Wright. "The assignment of lysine resonances in 1H NMR spectra of proteins." FEBS Lett. 222:1, 109-114 (1987).

11. W.J. Chazin and P.E. Wright. "A modified strategy for identification of 1H spin systems in proteins." Biopolymers 26, 973-977 (1987).

10. W.J. Chazin and K. Wüthrich. "RELAYED-COSY and DOUBLE RELAYED-COSY for assignment of 1H NMR spectra of proteins in H2O solution." J. Magn. Reson. 72:2, 358-363 (1987).

9. W.J. Chazin and L.D. Colebrook. "A proton spin-lattice relaxation pathway analysis of conformational preferences of aryl and enol ethers in some cinchona and morphine alkaloids.&quto; Can. J. Chem. 64:11, 2220-2224 (1986).

8. W. Leupin, W.J. Chazin, S. Hyberts, W.A. Denny and K. Wüthrich. "NMR studies of the complex between the decadeoxynucleotide d-(GCATTAATGC)2 and a minor groove binding drug." Biochemistry 25, 5902-5910 (1986).

7. W.J. Chazin, K. Wüthrich, S. Hyberts, M. Rance, W.A. Denny and W. Leupin. "1H NMR assignment for d-(GCATTAATGC)2 using experimental refinements of established procedures." J. Mol. Biol. 190, 439-453 (1986).

6. W.J. Chazin and L.D. Colebrook. "Use of proton spin-lattice relaxation and nuclear Overhauser effect data in structure analysis of alkaloids." J. Org. Chem. 51, 1243-1253 (1986).

5. W.J. Chazin, D.P. Goldenberg, T.E. Creighton and K. Wüthrich. "Comparative studies of conformation and internal mobility in native and circular basic pancreatic trypsin inhibitor by 1H nuclear magnetic resonance in solution." Eur. J. Biochem. 152, 429-437 (1985).

4. W.J. Chazin, L.D. Colebrook, B.R. Davis, I.R.N. McCormick and S.J. Johnson. "The stereochemistry of some 7-hydroxyindene dimers: applications of 1H nuclear magnetic resonance relaxation pathway analysis." Can. J. Chem. 63:8, 2332-2338 (1985).

3. W.J. Chazin and L.D. Colebrook "Steric influences on spin-lattice relaxation rates of methyl protons in substituted aromatic molecules." Magn. Reson. in Chem. 23:8, 597-604 (1985).

2. W.J. Chazin, J.T. Edward and L.D. Colebrook. "Relaxation pathway analysis by 1H spin-lattice relaxation and NOE difference measurements. Application to a reassignment of the 1H NMR spectrum of strychnine and to the determination of the structure and stereochemistry of some strychnine sulfonic acids." Can. J. Chem. 61:8, 1749-1755 (1983).

1. R. Blair, L. Switzman, D. Sinyor, W.J. Chazin, H. Cytryniak, F. Rogan, P. Shizgal and Z. Amit. "Lithium and ion chelators mimicked morphine in the production of explosive motor behavior." Behavioral and Neurol. Biol. 35, 408-416 (1982).

* = co-corresponding authors

Invited Contributions

43. C.A. Brosey, S. Tsutakawa, and W.J. Chazin. "Sample Preparation Methods to Analyze DNA-induced Structural Changes in Replication Protein A (RPA)." Methods in Molecular Biology XX, submitted.

42. A. Hermann, R. Donato, T.M. Weiger, and W.J. Chazin. "S100 Calcium-Binding Proteins and Ion Channels." Frontiers in Neuropharmacology XX, in press.

41. S. Damo, W.J. Chazin, E.P. Skaar, and T.E. Kehl-Fie. "Inhibition of bacterial superoxide defense: A new front in the struggle between host and pathogen." Virulence XX, in press.

40. S.M. Shell and W.J. Chazin. "XPF-ERCC1: On the bubble." Structure XX, in press (2010).

39. S.M. Damo, M.D. Feldkamp, B. Chagot, and W.J. Chazin. "NMR studies of the interaction of calmodulin with IQ motif peptides." Methods in Molecular Biology XX, in press (2012).

38. C.A. Brosey, M.-E. Chagot, and W.J. Chazin. "Preparation of the Modular Multi-Domain Protein RPA for Study by NMR Spectroscopy." In Protein NMR Techniques, A. Shekhtman and D.S. Burz (Eds.), Methods in Molecular Biology 831, 181-195 (2011).

37. W.J. Chazin. "Form and Function of EF-hand calcium binding proteins." Accounts of Chem. Res. 44, 171-179 (2011).

36. S. Ghavami, S.R. Ande, M. Hashemi, S. Chitayat, W.J. Chazin, A.J. Halayko, F. Karami-Tehrani, C. Kerkhoff and M. Los. "Apoptin, Brevinin-2R, and S100A8/A9; three anticancer proteins and peptides with different mechanisms of action." In "Proteins Killing Tumour Cells", Series: Cell Death and Disease Eds. Backendorf, Borst, Noteborn, Tavassoli, Research-Signpost, pp 291-245 (2010).

35. S.M. Shell and W.J. Chazin. "Biochemical and Structural Domain Analysis of Xeroderma Pigmentosum Complementation Group C Protein." In Structural Biology of DNA Damage, M.P. Stone (Ed.), American Chemical Society, Washington, chapter 8, pp. 59-71 (2010).

34. B. Chagot, M.R. Nelson and W.J. Chazin. "EF-hand Ca2+-binding Proteins." In Nature: Encyclopedia of Life Sciences, John Wiley & Sons, Ltd: Chichester. doi:10.1002/9780470015902.a0003056.pub2 (2009).

33. E. Fanning, X. Jiang, K. Zhao and W.J. Chazin. "Molecular Hand-off Mechanisms in DNA Replication." In Molecular Themes in DNA Replication, L.S. Cox (Ed.), Royal Society of Chemistry, London, chapter 6, pp. 156-177 (2009).

32. S. Ghavami, S. Chitayat, M. Hashemi, M. Eshraghi, W.J. Chazin, A.J. Halayko and C. Kerkhoff. "S100A8/A9: a Janus-faced molecule in cancer therapy and tumorgenesis." Eur. J. Pharm. 625, 73-83 (2009).

31. W.J. Chazin. "Evolution in the NIGMS Protein Structure Initiative." Structure 16, 12-14 (2008).

30. W.J. Chazin. "The impact of X-ray crystallography and NMR on intracellular calcium signal transduction by EF-hand proteins: Crossing the threshold from structure to biology and medicine." Science STKE 388, pe27 (3 pages) (2007).

29. Vikas N. Shah, Benjamin Chagot and Walter J. Chazin. "Calcium-Dependent Regulation of Ion Channels." Calcium Binding Proteins 1, 213-218 (2006).

28. C. Bunick and W.J. Chazin. "Two Blades of the [Ex]Scissor" Structure 13, 1740-1741 (2005).

27. S. Bhattacharya and W.J. Chazin. "Target Selectivity in EF-hand Calcium Binding Proteins." BBA-Molecular Cell Res. 1742, 69-79 (2004).

26. M.E. Stauffer and W.J. Chazin. "Structural Mechanisms of DNA Replication, Recombination, and Repair." J. Biol. Chem. 279, 30915-30918 (2004).

25. S. Bhattacharya and W.J. Chazin. "Calcium Driven Changes in S100A11 Structure Revealed." Structure 11, 738-740 (2003).

24. L. Mizoue and W.J. Chazin. "Protein design of ligand-induced conformational control." Curr. Opinion in Structural Biology, 12, 459-463 (2002).

23. G. Bifulco, J. A. Smith, W. J. Chazin and L. Gomez-Paloma. "Molecular Basis for Recognition and Binding of Specific DNA Sequences by Calicheamicin and Duocarmycin." Advances in DNA Sequence-Specific Agents 4, 47-73 (2002).

22. P.A. Fagan, M. Nelson, and W.J. Chazin. Entries: "Calmodulin; EF-hand". In Encyclopedia of Molecular Medicine, T. Creighton (ed.), J. Wiley & Sons, Inc., New York, vol. 5, pp. 430-433, 1134-1136 (2002).

21. M. Akke and W.J. Chazin. "An Open and Shut Case." Nature Struct. Biol. 8, 910-912 (2001).

20. M.R. Nelson and W.J. Chazin. "EF-hand Ca2+-binding Proteins." In Nature: Encyclopedia of Life Sciences @ London: Nature Publishing Group. doi:10.1038/npg.els.0003056] (2000).

19. G. Mer, A. Bochkarev, W.J. Chazin and A.M. Edwards. "Three-dimensional Structure and Function of Replication Protein A." Cold Spring Harbor Symp. Quant. Biol. Volume 65, 193-200 (2000).

18. N.J. Skelton and W.J. Chazin. "Solution Structure Determination of Proteins Using NMR Spectroscopy." In Peptide and Protein Analysis, R. Reid (ed.), Marcel Dekker, Inc., New York, 683-726 (1999).

17. M. Nelson, C. Weber and W.J. Chazin. Entries: "Calcium-binding proteins; Calmodulin; EDTA; EF-hand motif; EGTA; Parvalbumin." In Encyclopedia of Molecular Biology, T. Creighton (ed.), J. Wiley & Sons, Inc., New York, pp 330-332, 332-334, 782-783, 784-785, 787, 1768-1770 (1999).

16. M. Nelson and W.J. Chazin. "Structures of EF-hand Ca2+-binding Proteins: Diversity in the Organization, Packing and Response to Ca2+ Binding." Biometals 11, 297-318 (1998).

15. M. Nelson and W.J. Chazin. "Calmodulin as a calcium sensor." In Calmodulin and Signal Transduction, L.J. van Eldik & D.M. Watterson (eds.), Academic Press, Inc., pp. 17-64 (1998).

14. W.J. Chazin. "Incorporating motional properties into the interpretation of three-dimensional solution structures." In NMR as a Structural Tool for Macromolecules: Current Status and Future Directions, B.D. Nageswara Rao & M.D. Kemple (eds.), Plenum Press, New York, pp. 77-86 (1996).

13. S. Miick, G. Carlström, S.-M. Chen and W.J. Chazin. "NMR studies of synthetic models of the Holliday junction intermediate in genetic recombination." Meth. Enzym. 261, 163-182 (1995).

12. W.J. Chazin. "Releasing the calcium trigger." Nature Structural Biology 2, 707-710 (1995).

11. W.J. Chazin, G. Carlström, S.-M. Chen, S. Miick, L.G. Paloma, J. Smith and J. Rydzewski. "Complex DNA Structures and Structures of DNA Complexes." Proceedings of the Symposium on Stable Isotope Applications in Biomolecular Structure & Mechanism, Santa Fe, NM, pp. 43-57 (1995).

10. A.A. Kosiakoff and W.J. Chazin. "The role of secondary and tertiary structure in intramolecular deamidation of proteins." In Deamidation and Isoaspartate Formation in Peptides and Proteins, D.W. Aswad (ed.), CRC Press, Inc., pp. 193-206 (1994).

9. S. Forsén, J. Kördel, T. Grundström and W.J. Chazin. "The molecular anatomy of a calcium-binding protein." Accounts of Chem. Res. 26, 7-14 (1993).

8. W.J. Chazin. "NMR structure and methodology." Current Opinion in Biotechnology 3, 326-332 (1992).

7. T. Macke, S.-M. Chen, and W.J. Chazin. "Analysis of the structure and dynamics of synthetic 32 base-pair models of the Holliday junction intermediate in genetic recombination." In Structure and Function vol. 1, M.H Sarma & R.H. Sarma (eds.), Adenine Press Inc., Guilderland, N.Y., pp. 213-228 (1992).

6. M. Akke, N.J. Skelton, J. Kördel and W.J. Chazin. "Three-dimensional solution structure of calbindin D9k." In Techniques in Protein Chemistry III, J.J. Villafranca (ed.), Academic Press, San Diego, CA, pp 401-408 (1991).

5. M. Kalnik, W.J. Chazin and P.E. Wright. "Three-dimensional solution structure of human anaphylatoxin C3a." In Techniques in Protein Chemistry II, J.J. Villafranca (ed.), Academic Press, San Diego, pp 393-400 (1991).

4. S. Forsén, S. Linse, T. Drakenberg, J. Kördel, M. Akke, P. Sellers, C. Johansson, E. Thulin, E. Andersson, P. Brodin, T. Grundström, and W.J. Chazin. "Ca2+ binding in proteins of the calmodulin superfamily: cooperativity, electrostatic contributions, and molecular mechanisms" In Ciba Fdn. Symp. 161, Wiley-Interscience, New York, pp 222-236 (1991).

3. W.J. Chazin. "New NMR structure and structural methodology." Current Opinion in Biotechnology 2, 520-525 (1991).

2. M. Rance, W.J. Chazin, C. Dalvit and P.E. Wright. "Multiple quantum NMR." Meth. Enzym 176A, 114-134 (1989).

1. J. Kördel, S. Forsén and W.J. Chazin. "Analytical aspects of 2D NMR: Application to cis-trans isomerization of Pro43 in calbindin D9k." In Techniques in Protein Chemistry, T.E. Hugli (ed.), Academic Press, San Diego, CA, 239-247 (1989).

last updated 4/11/12