EF2: Consensus Position A9
Canonical consensus residue: hydrophobic residue
Please examine the alignments from which this page
was generated and read about how the alignments
were constructed to determine if the information on this page is suitable for your
needs.
In the following lists, the uppercase letters are wildtype residues from the different
species and various isoforms of the protein. The lowercase letters are mutations that
either occur naturally or have been engineered. Click on the link to see a page with
information about the effects of the mutation. In some cases, there may be more than
one mutant with the same mutation at a given site. Follow the links to see details about
each mutant.
S100 proteins
S100A1:
S100A10/p11:
S100A12/calgranulin C:
S100A2/S100L:
S100A3/S100E:
S100A4/placental calcium-binding protein:
S100A5/S100D:
S100A6/calcyclin:
S100A7/psoriasin:
S100A8/MRP-8:
S100A9/MRP-14:
full length isoform
S100B:
S100C:
S100P:
calbindin D9k:
calmodulin-like subfamily
calcium-dependent protein kinase:
isoform 1
- domain I: A
- domain II: I V
isoform 11
isoform 3
calmodulin:
isoform 1
- domain I: V A I
- domain II: A V
plant isoform 2
plant isoform 4
plant isoform 6
calmodulin-like protein:
- domain I: I V
- domain II: A V
caltractin:
isoform 1
- domain I: V I L Y
- domain II: A F
isoform 2
- domain I: Y V
- domain II: F A
isoform 2b
isoform 2c
squidulin:
troponin C:
cardiac isoform
lower animal isoform 1
- domain I: T V I
- domain II: I V
lower animal isoform 2
- domain I: T V
- domain II: V I
lower animal isoform 2A
lower animal isoform 2B
lower animal isoform 73F
skeletal isoform
- domain I: V
- domain II: G S
- domain I: V M
- domain II: T G Y
neuron specific calcium sensors
NCS-1:
hippocalcin:
recoverin:
calbindin D28k-like subfamily
calbindin D28k:
- domain I: Y
- domain II: F
- domain III: M
calretinin:
- domain I: Y
- domain II: F
- domain III: M
parvalbumins
parvalbumin:
alpha lineage
beta lineage
beta lineage isoform 1
beta lineage isoform 2
myosin light chains
myosin essential light chain:
cardiac muscle isoform
embryonic muscle isoform
lower animal isoform
- domain I: Q T
- domain II: L V T C
- domain III: -
skeletal muscle isoform
skeletal muscle isoform 2
slow-twitch muscle isoform
myosin regulatory light chain:
RLC 1
- domain I: C A
- domain II: L F A S K
- domain III: -
RLC 2
RLC 2 major smooth muscle isoform
RLC 2 minor smooth muscle isoform
- domain I: A
- domain II: A R
RLC 2 non-sarcomeric isoform
RLC 2 skeletal muscle isoform type 1
RLC 2 skeletal muscle isoform type 2
RLC 2 ventricular isoform type
RLC 2A cardiac muscle isoform
RLC 2A smooth muscle isoform
RLC 2B cardiac muscle isoform
RLC 2B smooth muscle isoform
RLC nonmuscle isoform
lower animal smooth muscle isoform
lower animal striated muscle isoform
- domain I: A S
- domain II: A
superfast RLC 2
calpain-like subfamily
ALG-2:
- domain I: F
- domain II: F
- domain III: -
calpain:
large subunit isoform I
- domain I: M
- domain II: Y
- domain III: -
large subunit isoform II
- domain I: L
- domain II: F
- domain III: -
large subunit isoform III
- domain I: M
- domain II: Y
- domain III: -
large subunit lower animal isoform
- domain I: V L
- domain II: Y
- domain III: -
small subunit
- domain I: M
- domain II: Y
- domain III: -
grancalcin:
- domain I: L
- domain II: Y
- domain III: -
sorcin:
- domain I: F L
- domain II: F Y
- domain III: -
other EF-hand CaBPs
SPARC/BM-40:
calcineurin B:
isoform 1
- domain I: F A
- domain II: A N
isoform 2
sarcoplasmic calcium-binding protein:
isoform I
- domain I: A
- domain II: I D
isoform II
shrimp alpha chain
shrimp beta chain
spectrin:
brain isoform alpha chain
erythroid isoform alpha chain
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