Targets for S100B

Proteins and small molecules whose interaction with S100B is thought to be biologically relevent are included in this table.

Target Protein	Evidence of Interaction	Effect of Interaction
p53	biochemical evidence in Bos taurus: p53 was shown to bind to S100B in a calcium-dependent manner by affinity chromatography: p53 is retained on a S100B-sepharose column in the presence of calcium, and eluted by the addition of EGTA (InfoCard) spectroscopic evidence in Rattus norvegicus: Fluorescence and nuclear magnetic resonance spectra of S100B showed specific changes upon the addition of p53 (InfoCard)	in Bos taurus: S100B binding to p53 inhibits phosphorylation of p53 by protein kinase C (InfoCard) in Bos taurus: S100B binding to p53 inhibits oligomerization of p53 (InfoCard)
S100A1	biochemical evidence in Bos taurus: S100A1 and S100B can be isolated as a complex from bovine brain (InfoCard)
phosphoglucomutase	biochemical evidence in Bos taurus: Affinity chromatography demonstrates that phosphoglucomutase binds to S100B-Sepharose, and S100B binds to phosphoglucomutase-Sepharose in a calcium-dependent manner (InfoCard)	in Bos taurus: S100B stimulates phosphoglucomutase activity in a calcium-dependent manner (InfoCard)