Information in the EF-Hand Calcium-Binding Proteins Database from Reference 625

Information in the EF-Hand Calcium-Binding Proteins Database from Reference 625

Protein	Species	Information	Submitted By	Validated By
calmodulin isoform 1 the main isoform, and the only isoform found in most species	Saccharomyces cerevisiae (bakers yeast)	Report of an engineered mutant with following mutations: F12A	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F12A	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: can activate calcineurin	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F12A	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: Percent activation (relative to wildtype) = 54 %	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 the main isoform, and the only isoform found in most species	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: can activate calcineurin	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 the main isoform, and the only isoform found in most species	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: Percent activation (relative to wildtype) = 100 %	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 the main isoform, and the only isoform found in most species	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: K_act = 61 nM	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 the main isoform, and the only isoform found in most species	Saccharomyces cerevisiae (bakers yeast)	Report of an engineered mutant with following mutations: F16A	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F16A	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: can activate calcineurin	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F16A	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: Percent activation (relative to wildtype) = 102 %	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F16A	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: K_act = 170 nM	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F16A	Saccharomyces cerevisiae (bakers yeast)	biochemical evidence of interaction with calcineurin: Activation was observed in vitro	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 the main isoform, and the only isoform found in most species	Saccharomyces cerevisiae (bakers yeast)	Report of an engineered mutant with following mutations: F19A	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F19A	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: can activate calcineurin	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F19A	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: Percent activation (relative to wildtype) = 13 %	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F19A	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: K_act = 130 nM	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F19A	Saccharomyces cerevisiae (bakers yeast)	biochemical evidence of interaction with calcineurin: Activation was observed in vitro	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 the main isoform, and the only isoform found in most species	Saccharomyces cerevisiae (bakers yeast)	Report of an engineered mutant with following mutations: F16A F19A	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F16A F19A	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: can activate calcineurin	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F16A F19A	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: Percent activation (relative to wildtype) = 20 %	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F16A F19A	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: K_act = 630 nM	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F16A F19A	Saccharomyces cerevisiae (bakers yeast)	biochemical evidence of interaction with calcineurin: Activation was observed in vitro	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F65A F68A	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: can activate calcineurin	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F65A F68A	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: Percent activation (relative to wildtype) = 64 %	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F65A F68A	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: K_act = 81 nM	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F65A F68A	Saccharomyces cerevisiae (bakers yeast)	biochemical evidence of interaction with calcineurin: Activation was observed in vitro	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 the main isoform, and the only isoform found in most species	Saccharomyces cerevisiae (bakers yeast)	Report of an engineered mutant with following mutations: F89A	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F89A	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: can activate calcineurin	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F89A	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: Percent activation (relative to wildtype) = 86 %	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F89A	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: K_act = 98 nM	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F89A	Saccharomyces cerevisiae (bakers yeast)	biochemical evidence of interaction with calcineurin: Activation was observed in vitro	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 the main isoform, and the only isoform found in most species	Saccharomyces cerevisiae (bakers yeast)	Report of an engineered mutant with following mutations: F92A	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F92A	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: can activate calcineurin	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F92A	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: Percent activation (relative to wildtype) = 89 %	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F92A	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: K_act = 160 nM	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F92A	Saccharomyces cerevisiae (bakers yeast)	biochemical evidence of interaction with calcineurin: Activation was observed in vitro	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 the main isoform, and the only isoform found in most species	Saccharomyces cerevisiae (bakers yeast)	Report of an engineered mutant with following mutations: F140A	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F140A	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: can activate calcineurin	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F140A	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: Percent activation (relative to wildtype) = 59 %	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: F140A	Saccharomyces cerevisiae (bakers yeast)	Information about the activation of calcineurin by this protein: K_act = 230 nM	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu