| Protein |
Species |
Information |
Comment |
Submitted By |
Validated By |
|---|---|---|---|---|---|
| calmodulin isoform 1 the main isoform, and the only isoform found in most species |
Bos taurus (cow or bovine) |
Report of an engineered mutant with following mutations:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 the main isoform, and the only isoform found in most species |
Bos taurus (cow or bovine) |
Report of an engineered mutant with following mutations:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 the main isoform, and the only isoform found in most species |
Bos taurus (cow or bovine) |
Report of an engineered mutant with following mutations:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 the main isoform, and the only isoform found in most species |
Bos taurus (cow or bovine) |
Report of an engineered mutant with following mutations:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 the main isoform, and the only isoform found in most species |
Bos taurus (cow or bovine) |
Report of an engineered mutant with following mutations:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 the main isoform, and the only isoform found in most species |
Bos taurus (cow or bovine) |
Report of an engineered mutant with following mutations:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 the main isoform, and the only isoform found in most species |
Bos taurus (cow or bovine) |
Report of an engineered mutant with following mutations:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 the main isoform, and the only isoform found in most species |
Bos taurus (cow or bovine) |
Report of an engineered mutant with following mutations:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 the main isoform, and the only isoform found in most species |
Bos taurus (cow or bovine) |
Report of an engineered mutant with following mutations:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 the main isoform, and the only isoform found in most species |
Bos taurus (cow or bovine) |
Report of an engineered mutant with following mutations:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 the main isoform, and the only isoform found in most species |
Bos taurus (cow or bovine) |
Report of an engineered mutant with following mutations:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 the main isoform, and the only isoform found in most species |
Bos taurus (cow or bovine) |
Report of an engineered mutant with following mutations:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
Dramatically decreases CaM's ability to activate PDE. M36L-CaM can not fully activate PDE | Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
The activation of PDE by this mutant form of CaM is nearly indistinguishable from that achieved by wildtype CaM | Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
Can activate PDE fully, but must be present at a higher concentration than is required to acheive full PDE activation with wildtype CaM | Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
Activation of PDE by this mutant is nearly indistinguishable from that acheived by wildtype CaM | Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
Can fully activate PDE, but must be present at a higher concentration than required for wildtype CaM | Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
The activation of PDE by this mutant form of CaM is nearly indistinguishable from that achieved by wildtype CaM | Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
This mutant form of CaM can fully activate PDE, but must be present at higher concentrations than required for wildtype CaM to achieve full PDE activation | Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
The activation of PDE by this mutant form of CaM is nearly indistinguishable from that achieved by wildtype CaM | Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
This mutant is able to activate PDE fully, but must be present at higher concentrations than wildtype CaM needs to be to activate PDE fully. This double mutant activates PDE better than the single mutant M36L, which cannot fully activate PDE | Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
The activation of PDE by this mutant is nearly indistiniguishable from the activation achieved by wildtype CaM. This double mutant is beter at activating PDE than either of the single mutants M71L and M72L are | Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
This mutant is almost completely unable to activate PDE, despite the fact that the single mutant M145L activates PDE nearly as well as wildtype CaM does | Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
This mutant replaces all four of the conserved methionines in the C-terminal domain of CaM with leucine. It is able to fully activate PDE, but with a K(act) about 5 times as high as that of wildtype CaM | Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
biochemical evidence of interaction with calmodulin-dependent cyclic nucleotide phosphodiesterase:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
Information about the activation of calmodulin-dependent cyclic nucleotide phosphodiesterase by this protein:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
Information about the activation of calmodulin-dependent cyclic nucleotide phosphodiesterase by this protein:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
biochemical evidence of interaction with calmodulin-dependent cyclic nucleotide phosphodiesterase:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
biochemical evidence of interaction with calmodulin-dependent cyclic nucleotide phosphodiesterase:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
Information about the activation of calmodulin-dependent cyclic nucleotide phosphodiesterase by this protein:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
biochemical evidence of interaction with calmodulin-dependent cyclic nucleotide phosphodiesterase:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
Information about the activation of calmodulin-dependent cyclic nucleotide phosphodiesterase by this protein:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
biochemical evidence of interaction with calmodulin-dependent cyclic nucleotide phosphodiesterase:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
Information about the activation of calmodulin-dependent cyclic nucleotide phosphodiesterase by this protein:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
biochemical evidence of interaction with calmodulin-dependent cyclic nucleotide phosphodiesterase:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
Information about the activation of calmodulin-dependent cyclic nucleotide phosphodiesterase by this protein:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
biochemical evidence of interaction with calmodulin-dependent cyclic nucleotide phosphodiesterase:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
biochemical evidence of interaction with calmodulin-dependent cyclic nucleotide phosphodiesterase:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
Information about the activation of calmodulin-dependent cyclic nucleotide phosphodiesterase by this protein:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
Information about the activation of calmodulin-dependent cyclic nucleotide phosphodiesterase by this protein:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
biochemical evidence of interaction with calmodulin-dependent cyclic nucleotide phosphodiesterase:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
biochemical evidence of interaction with calmodulin-dependent cyclic nucleotide phosphodiesterase:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
biochemical evidence of interaction with calmodulin-dependent cyclic nucleotide phosphodiesterase:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
Information about the activation of calmodulin-dependent cyclic nucleotide phosphodiesterase by this protein:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
Information about the activation of calmodulin-dependent cyclic nucleotide phosphodiesterase by this protein:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
Information about the activation of calmodulin-dependent cyclic nucleotide phosphodiesterase by this protein:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |
|
| calmodulin isoform 1 mutant:
|
Bos taurus (cow or bovine) |
Information about the activation of calmodulin-dependent cyclic nucleotide phosphodiesterase by this protein:
|
Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu |
Melanie R. Nelson mnelson@scripps.edu |