Information in the EF-Hand Calcium-Binding Proteins Database from Reference 152

Information in the EF-Hand Calcium-Binding Proteins Database from Reference 152

Protein	Species	Information	Submitted By	Validated By
calmodulin isoform 1 the main isoform, and the only isoform found in most species	Bos taurus (cow or bovine)	Report of an engineered mutant with following mutations: I125M	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 the main isoform, and the only isoform found in most species	Bos taurus (cow or bovine)	Report of an engineered mutant with following mutations: R126K	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 the main isoform, and the only isoform found in most species	Bos taurus (cow or bovine)	Report of an engineered mutant with following mutations: E127D	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 the main isoform, and the only isoform found in most species	Bos taurus (cow or bovine)	Report of an engineered mutant with following mutations: A128G	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: M124L	Bos taurus (cow or bovine)	Shows reduced ability to activate myosin light chain kinase (81% of max) and nitric oxide synthase (65% of max)	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: I125M	Bos taurus (cow or bovine)	Shows wildtype ability to activate myosin light chain kinase (103% of max), but reduced ability to activate nitric oxide synthase (84% of max)	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: R126K	Bos taurus (cow or bovine)	Shows near wildtype ability to activate myosin light chain kinase (98% of max), but slightly reduced ability to activate nitric oxide synthase (88% of max)	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: E127D	Bos taurus (cow or bovine)	Shows slightly reduced ability to activate myosin light chain kinase (83% of max) nitric oxide synthase (80% of max)	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: A128G	Bos taurus (cow or bovine)	Shows near wildtype ability to activate myosin light chain kinase (93% of max), but reduced ability to activate nitric oxide synthase (79% of max)	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: M124L	Bos taurus (cow or bovine)	biochemical evidence of interaction with smooth muscle myosin light chain kinase: This mutant of calmodulin was able to activate smooth muscle MLCK in vitro	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: M124L	Bos taurus (cow or bovine)	Information about the activation of smooth muscle myosin light chain kinase by this protein: partially activate smooth muscle myosin light chain kinase Percent activation (relative to wildtype) = 81 %	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: M124L	Bos taurus (cow or bovine)	Information about the activation of neuronal nitric oxide synthase by this protein: partially activate neuronal nitric oxide synthase Percent activation (relative to wildtype) = 65 %	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: M124L	Bos taurus (cow or bovine)	biochemical evidence of interaction with neuronal nitric oxide synthase: This mutant of calmodulin was able to activate neuronal NOS in vitro	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: I125M	Bos taurus (cow or bovine)	biochemical evidence of interaction with smooth muscle myosin light chain kinase: This mutant of calmodulin was able to activate smooth muscle MLCK in vitro	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: I125M	Bos taurus (cow or bovine)	biochemical evidence of interaction with neuronal nitric oxide synthase: This mutant of calmodulin was able to partially activate neuronal NOS in vitro	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: I125M	Bos taurus (cow or bovine)	Information about the activation of smooth muscle myosin light chain kinase by this protein: can activate smooth muscle myosin light chain kinase Percent activation (relative to wildtype) = 103 %	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: I125M	Bos taurus (cow or bovine)	Information about the activation of neuronal nitric oxide synthase by this protein: partially activate neuronal nitric oxide synthase Percent activation (relative to wildtype) = 84 %	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: R126K	Bos taurus (cow or bovine)	biochemical evidence of interaction with neuronal nitric oxide synthase: This mutant of calmodulin was able to partially activate neuronal NOS in vitro	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: R126K	Bos taurus (cow or bovine)	biochemical evidence of interaction with smooth muscle myosin light chain kinase: This mutant of calmodulin was able to activate smooth muscle MLCK in vitro	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: R126K	Bos taurus (cow or bovine)	Information about the activation of neuronal nitric oxide synthase by this protein: partially activate neuronal nitric oxide synthase Percent activation (relative to wildtype) = 88 %	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: R126K	Bos taurus (cow or bovine)	Information about the activation of smooth muscle myosin light chain kinase by this protein: can activate smooth muscle myosin light chain kinase Percent activation (relative to wildtype) = 98 %	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: E127D	Bos taurus (cow or bovine)	biochemical evidence of interaction with smooth muscle myosin light chain kinase: This mutant of calmodulin was able to activate smooth muscle MLCK in vitro	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: E127D	Bos taurus (cow or bovine)	biochemical evidence of interaction with neuronal nitric oxide synthase: This mutant of calmodulin was able to partially activate neuronal NOS in vitro	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: E127D	Bos taurus (cow or bovine)	Information about the activation of smooth muscle myosin light chain kinase by this protein: partially activate smooth muscle myosin light chain kinase Percent activation (relative to wildtype) = 83 %	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: E127D	Bos taurus (cow or bovine)	Information about the activation of neuronal nitric oxide synthase by this protein: partially activate neuronal nitric oxide synthase Percent activation (relative to wildtype) = 83 %	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: A128G	Bos taurus (cow or bovine)	biochemical evidence of interaction with neuronal nitric oxide synthase: This mutant of calmodulin was able to partially activate neuronal NOS in vitro	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: A128G	Bos taurus (cow or bovine)	biochemical evidence of interaction with smooth muscle myosin light chain kinase: This mutant of calmodulin was able to activate smooth muscle MLCK in vitro	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: A128G	Bos taurus (cow or bovine)	Information about the activation of neuronal nitric oxide synthase by this protein: partially activate neuronal nitric oxide synthase Percent activation (relative to wildtype) = 79 %	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu
calmodulin isoform 1 mutant: A128G	Bos taurus (cow or bovine)	Information about the activation of smooth muscle myosin light chain kinase by this protein: partially activate smooth muscle myosin light chain kinase Percent activation (relative to wildtype) = 93 %	Melanie R. Nelson The Scripps Research Institute, Department of Molecular Biology mnelson@scripps.edu	Melanie R. Nelson mnelson@scripps.edu