| Additional names and abbreviations: | No additional names are stored in the database |
|---|---|
| Isoforms: | No information about isoforms is stored in the database |
| Yeast Protein Database Entries: | No links to the YPD are stored in the database |
| Basic Chemical and Physical
Information: |
|
| Number of amino acids: | 100 (Homo sapiens) - 101 (Bos taurus) View a list of all sources stored in the database |
| Molecular weight: | 11.326 kD (Homo sapiens) - 11.544 kD (Bos taurus) View a list of all sources stored in the database |
| pI: | calculated pI (Homo sapiens) = 6.77 (InfoCard) experimental pI (Homo sapiens) = 6.2 (InfoCard) |
| Number of functional calcium binding sites: | Homo sapiens: 1 (InfoCard) |
| Macroscopic calcium binding constants: | not yet available in the data library |
| Other metal binding constants: | not yet available in the data library |
| Protein stability: | not yet available in the data library |
| Post-translational modifications: | not yet available in the data library |
| Basic Biological
Information: |
|
| Source organisms: | Bos taurus,
Homo sapiens
View an annotated list of all sources stored in the database |
| Tissues: | Homo sapiens: fetaltissues containing stratified epithelium (InfoCard) Homo sapiens: adult keratinocytes (InfoCard) |
| Subcellular localization: | not yet available in the data library |
| Regulation: | not yet available in the data library |
| Genomic Information: |
|
| GenBank entries: | View a list of GenBank entries
stored in the database |
| Gene length: | not yet available in the data library |
| Gene structure: | not yet available in the data library |
| Promoter: | not yet available in the data library |
| Gene copies: | not yet available in the data library |
| Alleles: | no alleles are currently stored in the data library |
| Chromosomal localization: | Homo sapiens, expressed (GenBank code AF050167): q21 region of chromosome 1 (part of the cluster of S100 protein genes) (InfoCard) |
not yet available in the data library
General information:
Biological roles:
Disease states:
Target molecules:
| Calcium-coordination: |
|
|---|---|
| not yet available in the data library |
|
| Nature of the conformational
changes: |
|
| Conformational change between one calcium ion bound and one zinc ion bound and one calcium ion bound states: |
Asp 24 (which is part of the N-terminal EF-hand loop and binds zinc) turns away from the zinc-binding site and imposes a conformational change in the otherwise distorted EF-loop that causes it to resemble a calcium-bound loop. Thus, binding/release of zinc from the protein could have an impact on the calcium affinity. (InfoCard) |
| Secondary structure: (as reported in the PDB file and its accompanying reference) |
|
| not yet available in the data library |
|
| Additional structural information: | |
|
|
| Available structures: (follow the links from the PDB code to the retrieve the PDB files) |
|
| Calcium Loaded Structures: |
1PSR: Homo sapiens, homodimer, pH 8 Crystal structure, 1.05 angstrom resolution, R-value = 10.49, R-free = 14.12 1 Ca ion bound (InfoCard) |
| Other Metal Bound Structures: |
2PSR: Homo sapiens, homodimer, pH 6.7 Crystal structure, 2.05 angstrom resolution, R-value = 21.65, R-free = 26.45 1 Zn ion bound 1 Ca ion bound (InfoCard) 3PSR: Homo sapiens, homodimer, zinc bound to monomer A only, pH 7.7 Crystal structure, 2.5 angstrom resolution, R-value = 22.3, R-free = 29.53 1 Zn ion bound 1 Ca ion bound (InfoCard) |