CaBP Data Library General Information

Calbindin D28k

Primary information about calbindin D28k:
Basic chemical and physical information
Basic biological information
Basic genomic information
Metal ion binding constants
Interspecies sequence alignment
Information on function
Summary of structural studies
Information on the conformational change List of available structures Information about mutations
References about calbindin D28k Other web resources about calbindin D28k
Additional information about calbindin D28k:
Information about the evolutionary relationship of calbindin D28k to other proteins






Basic Information

Additional names and abbreviations: calbindin D28k: vitamin D-dependent calcium-binding protein
Isoforms: No information about isoforms is stored in the database
Yeast Protein Database Entries: No links to the YPD are stored in the database


Basic Chemical and Physical Information:
Number of amino acids: 260 (Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens) - 261 (Gallus gallus)
View a list of all sources stored in the database
Molecular weight: 29.384 kD (Bos taurus) - 30.036 kD (Gallus gallus)
View a list of all sources stored in the database
pI: not yet available in the data library
Number of functional calcium binding sites: not yet available in the data library
Macroscopic calcium binding constants: not yet available in the data library
Other metal binding constants: not yet available in the data library
Protein stability: not yet available in the data library
Post-translational modifications: not yet available in the data library


Basic Biological Information:
Source organisms: Bos taurus, Gallus gallus, Homo sapiens, Mus musculus, Rattus norvegicus
View an annotated list of all sources stored in the database
Tissues: birds: intestine (InfoCard)
mammals: brain (InfoCard)
mammals: kidney (InfoCard)
mammals: pancreas (InfoCard)
Gallus gallus: egg shell gland (uterus) (InfoCard)
Subcellular localization: not yet available in the data library
Regulation: all sources: regulated by Vitamin D (upregulates expression) (InfoCard)


Genomic Information:
GenBank entries: View a list of GenBank entries stored in the database
Gene length: not yet available in the data library
Gene structure: not yet available in the data library
Promoter: not yet available in the data library
Gene copies: not yet available in the data library
Alleles: no alleles are currently stored in the data library
Chromosomal localization: Homo sapiens, expressed (GenBank code X06661): q21.3-2 region of chromosome 8 (InfoCard)

Interspecies Sequence Alignment



                     |-helixI-|--loop1----|helixII-|
                     En**nn**nX*Y*ZG#Ix**zn**nn**n*

MOUSE  : -AESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQNLIQELL
RAT    : -AESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQNLIQELL
HUMAN  : -AESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQNLIQELQ
BOVINE : -AESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQNLIQELQ
CHICK  : TAETHLQGVEISAAQFFEIWHHYDSDGNGYMDGKELQNFIQELQ

                     |helixIII|--loop2----|helixIV|
                     En**nn**nX*Y*ZG#Ix**zn**nn**n*

MOUSE  : QARKKAGLELSPEMKSFVDQYGQRDDGKIGIVELAHVLPTEENF
RAT    : QARKKAGLELSPEMKTFVDQYGQRDDGKIGIVELAHVLPTEENF
HUMAN  : QARKKAGLELSPEMKTFVDQYGQRDDGKIGIVELAHVLPTEENF
BOVINE : QARKKAGLELSPEMKTFVDQYGERDDGKIGIVELAHVLPTEENF
CHICK  : QARKKAGLDLTPEMKAFVDQYGKATDGKIGIVELAQVLPTEENF

                       |helixV-|-loop3-----|helixVI-|
                       En**nn**nX*Y*ZG#Ix**zn**nn**n*

MOUSE  : LLLFRC-QQLKSCEEFMKTWRKYDTDHSGFIETEELKNFLKDLLEKANKTVDDTKLAE
RAT    : LLLFRC-QQLKSCEEFMKTWRKYDTDHSGFIETEELKNFLKDLLEKANKTVDDTKLAE
HUMAN  : LLLFRC-QQLKSCEEFMKTWRKYDTDHSGFIETEELKNFLKDLLEKANKTVDDTKLAE
BOVINE : LLLFRC-QQLKSCEEFMKTWRKYDTDHSGFIETEELKNFLKDLLEKANKTVDDTKLAE
CHICK  : LLFFRC-QQLKSSEDFMQTWRKYDSDHSGFIDSEELKSFLKDLLQKANKQIEDSKLTE

        |helixVII|--loop4-----|hlxVIII|
         En**nn**nX*Y*ZG#Ix**zn**nn**n*              

MOUSE  : YTDLMLKLFDSNNDGKLELTEMARLLPVQENFLLKFQGIKMCGK
RAT    : YTDLMLKLFDSNNDGKLELTEMARLLPVQENFLLKFQGIKMCGK
HUMAN  : YTDLMLKLFDSNNDGKLELTEMARLLPVQENFLLKFQGIKMCGK
BOVINE : YTDLMLKLFDSNNDGKLELTEMARLLPVQENFLLKFQGVKMCGK
CHICK  : YTEIMLRMFDANNDGKLELTELARLLPVQENFLIKFQGVKMCAK

         |hlxIX--|--loop5----|-helixX-|
         En**nn**nX*Y*ZG#Ix**zn**nn**n*

MOUSE  : EFNKAFELYDQDGNGYIDENELDALLKDLCEKNKQELDINN
RAT    : NGYIDENELDALLKDLCEKNKQELDINNEFNKAFELYDQDG
HUMAN  : NGYIDENELDALLKDLCEKNKQDLDINNEFNKAFELYDQDG
BOVINE : DGYIDENELDALLKDLCEKNKQDLDINNEFNKAFELYDQDG
CHICK  : NGYIDENELDALLKDLCEKNKKELDINNEFNKAFEMYDQDG

         |hlxXI--|--loop6----|helixXII|
         En**nn**nX*Y*ZG#Ix**zn**nn**n*

MOUSE  : ITTYKKNIMALSDGGKLYRTDLALILSAGDN
RAT    : ISTYKKNIMALSDGGKLYRTDLALILSAGDN
HUMAN  : ITTYKKNIMALSDGGKLYRTDLALILCAGDN
BOVINE : IPTYKKSIMALSDGGKLYRTDLALILSAGDN
CHICK  : LATYKKSIMALSDGGKLYRAELALILCAEEN


Sequence alignment for entire calbindin D28k/calretinin subfamily

Functional Information:

General information:

Biological roles:

Disease states:

Target molecules:


Structural Information:

Calcium-coordination:
not yet available in the data library


Nature of the conformational changes:
not yet available in the data library


Secondary structure:
(as reported in the PDB file and its accompanying reference)
not yet available in the data library


Additional structural information:
no additional structural information is currently stored in the database


Available structures:
(follow the links from the PDB code to the retrieve the
PDB files)
no structures are currently stored in the database

Information about mutants: